scholarly journals Effects of lighting environment on the degeneration of retinal ganglion cells in glutamate/aspartate transporter deficient mice, a mouse model of normal tension glaucoma

2022 ◽  
Vol 29 ◽  
pp. 101197
Author(s):  
Tsutomu Ohashi ◽  
Kazuhiko Namekata ◽  
Xiaoli Guo ◽  
Atsuko Kimura ◽  
Chikako Harada ◽  
...  
Heliyon ◽  
2016 ◽  
Vol 2 (10) ◽  
pp. e00191 ◽  
Author(s):  
Zhenyu Dong ◽  
Yasuhiro Shinmei ◽  
Yoko Dong ◽  
Saori Inafuku ◽  
Junichi Fukuhara ◽  
...  

2007 ◽  
Vol 179 (7) ◽  
pp. 1523-1537 ◽  
Author(s):  
Gareth R. Howell ◽  
Richard T. Libby ◽  
Tatjana C. Jakobs ◽  
Richard S. Smith ◽  
F. Campbell Phalan ◽  
...  

Here, we use a mouse model (DBA/2J) to readdress the location of insult(s) to retinal ganglion cells (RGCs) in glaucoma. We localize an early sign of axon damage to an astrocyte-rich region of the optic nerve just posterior to the retina, analogous to the lamina cribrosa. In this region, a network of astrocytes associates intimately with RGC axons. Using BAX-deficient DBA/2J mice, which retain all of their RGCs, we provide experimental evidence for an insult within or very close to the lamina in the optic nerve. We show that proximal axon segments attached to their cell bodies survive to the proximity of the lamina. In contrast, axon segments in the lamina and behind the eye degenerate. Finally, the Wlds allele, which is known to protect against insults to axons, strongly protects against DBA/2J glaucoma and preserves RGC activity as measured by pattern electroretinography. These experiments provide strong evidence for a local insult to axons in the optic nerve.


2014 ◽  
Vol 522 (18) ◽  
pp. 4085-4099 ◽  
Author(s):  
Christopher W. Yee ◽  
Abduqodir H. Toychiev ◽  
Elena Ivanova ◽  
Botir T. Sagdullaev

2021 ◽  
pp. 108728
Author(s):  
Dongmei Liu ◽  
Qinqin Deng ◽  
Xinlan Lei ◽  
Wei Lu ◽  
Qingqing Zhao ◽  
...  

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Siqi Xiong ◽  
Ajay Kumar ◽  
Shenghe Tian ◽  
Eman E Taher ◽  
Enzhi Yang ◽  
...  

Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if transplanted stem cells are able to rescue a glaucoma mouse model with transgenic myocilin Y437H mutation and explored the possible mechanisms. Human trabecular meshwork stem cells (TMSCs) were intracamerally transplanted which reduced mouse intraocular pressure, increased outflow facility, protected the retinal ganglion cells and preserved their function. TMSC transplantation also significantly increased the TM cellularity, promoted myocilin secretion from TM cells into the aqueous humor to reduce endoplasmic reticulum stress, repaired the TM tissue with extracellular matrix modulation and ultrastructural restoration. Co-culturing TMSCs with myocilin mutant TM cells in vitro promoted TMSCs differentiating into phagocytic functional TM cells. RNA sequencing revealed that TMSCs had upregulated genes related to TM regeneration and neuroprotection. Our results uncovered therapeutic potential of TMSCs for curing glaucoma and elucidated possible mechanisms by which TMSCs achieve the treatment effect.


2011 ◽  
Vol 52 (12) ◽  
pp. 8754 ◽  
Author(s):  
Noriko Nakano ◽  
Hanako Ohashi Ikeda ◽  
Masanori Hangai ◽  
Yuki Muraoka ◽  
Yoshinobu Toda ◽  
...  

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