scholarly journals The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice

2009 ◽  
Vol 77 (7) ◽  
pp. 1151-1160 ◽  
Author(s):  
Wayne A. Fritz ◽  
Tien-Min Lin ◽  
Stephen Safe ◽  
Robert W. Moore ◽  
Richard E. Peterson
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Tumor Metastasis ◽  
Prostate Tumor ◽  
Aryl Hydrocarbon ◽  
Receptor Modulator ◽  
Tramp Mice

scholarly journals The aryl hydrocarbon receptor inhibits prostate carcinogenesis in TRAMP mice

2006 ◽  
Vol 28 (2) ◽  
pp. 497-505 ◽  
Author(s):  
W. A. Fritz ◽  
T.-M. Lin ◽  
R. D. Cardiff ◽  
R. E. Peterson
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon ◽  
Prostate Carcinogenesis ◽  
Tramp Mice

Carbidopa: a selective Ah receptor modulator (SAhRM)

2017 ◽  
Vol 474 (22) ◽  
pp. 3763-3765 ◽  
Author(s):  
Stephen Safe
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Growth ◽  
Aryl Hydrocarbon Receptor ◽  
Pancreatic Cancer Cell ◽  
Clinical Applications ◽  
Ah Receptor ◽  
High Affinity ◽  
Aryl Hydrocarbon ◽  
Receptor Modulator ◽  
Intracellular Receptor

The aryl hydrocarbon receptor (AhR) was discovered as the intracellular receptor that bound with high affinity to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and the AhR is required for mediating the toxicity induced by TCDD. Subsequent studies show that the AhR binds structurally diverse chemicals including plant-derived compounds that promote health and several AhR-active pharmaceuticals that exhibit anticancer activity. In this issue, there is a report that carbidopa, a drug used for treating Parkinson's disease, is also an AhR ligand, and this compound inhibits pancreatic cancer cell and tumor growth. These results are consistent with activities of other AhR-active compounds that inhibit carcinogenesis. Like carbidopa, these chemicals are selective AhR modulators with potential clinical applications that are AhR-dependent.

scholarly journals Activation of the Aryl Hydrocarbon Receptor by TCDD Inhibits Mammary Tumor Metastasis in a Syngeneic Mouse Model of Breast Cancer

2011 ◽  
Vol 124 (2) ◽  
pp. 291-298 ◽  
Author(s):  
Tao Wang ◽  
Katie L. Wyrick ◽  
Gary G. Meadows ◽  
Tamara B. Wills ◽  
Beth A. Vorderstrasse
Keyword(s):  
Breast Cancer ◽  
Mouse Model ◽  
Aryl Hydrocarbon Receptor ◽  
Mammary Tumor ◽  
Tumor Metastasis ◽  
Syngeneic Mouse ◽  
Aryl Hydrocarbon ◽  
Syngeneic Mouse Model

scholarly journals Selective Aryl Hydrocarbon Receptor Modulator-Mediated Repression of CD55 Expression Induced by Cytokine Exposure

2012 ◽  
Vol 342 (2) ◽  
pp. 345-355 ◽  
Author(s):  
Gitanjali A. Narayanan ◽  
Iain A. Murray ◽  
Gowdahalli Krishnegowda ◽  
Shantu Amin ◽  
Gary H. Perdew
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon ◽  
Receptor Modulator
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