Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists

Behavioral Deficits ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Deficient Mice

Nicotine Accelerates Atherosclerosis in Apolipoprotein E–Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.116.307264 ◽

2017 ◽

Vol 37 (1) ◽

pp. 53-65 ◽

Cited By ~ 27

Author(s):

Chen Wang ◽

Han Chen ◽

Wei Zhu ◽

Yinchuan Xu ◽

Mingfei Liu ◽

...

Keyword(s):

Mast Cells ◽

Apolipoprotein E ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Deficient Mice

Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis

British Journal of Pharmacology ◽

10.1111/j.1476-5381.2010.00699.x ◽

2010 ◽

Vol 160 (2) ◽

pp. 322-333 ◽

Cited By ~ 58

Author(s):

Susanne A Snoek ◽

Marleen I Verstege ◽

Esmerij P van der Zanden ◽

Nigel Deeks ◽

David C Bulmer ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Experimental Colitis ◽

Nicotinic Acetylcholine ◽

Receptor Agonists

3 α7 Nicotinic Acetylcholine Receptor Agonists and Positive Allosteric Modulators

Progress in Medicinal Chemistry - Progress in Medicinal Chemistry Volume 46 ◽

10.1016/s0079-6468(07)00003-3 ◽

2008 ◽

pp. 131-171 ◽

Cited By ~ 31

Author(s):

Andrew P. Lightfoot ◽

James N.C. Kew ◽

John Skidmore

Keyword(s):

Acetylcholine Receptor ◽

Allosteric Modulators ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Positive Allosteric Modulators

Stimulation of α7 nicotinic acetylcholine receptor by AR-R17779 suppresses atherosclerosis and aortic aneurysm formation in apolipoprotein E-deficient mice

Vascular Pharmacology ◽

10.1016/j.vph.2014.03.006 ◽

2014 ◽

Vol 61 (2-3) ◽

pp. 49-55 ◽

Cited By ~ 19

Author(s):

Toru Hashimoto ◽

Toshihiro Ichiki ◽

Aya Watanabe ◽

Eva Hurt-Camejo ◽

Erik Michaëlsson ◽

...

Keyword(s):

Aortic Aneurysm ◽

Apolipoprotein E ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Aneurysm Formation ◽

Deficient Mice ◽

Stimulation Of

Effects of α7 nicotinic acetylcholine receptor agonists on antipsychotic efficacy in a preclinical mouse model of psychosis

Psychopharmacology ◽

10.1007/s00213-011-2535-6 ◽

2011 ◽

Vol 220 (4) ◽

pp. 823-833 ◽

Cited By ~ 13

Author(s):

Kathy L. Kohlhaas ◽

Robert S. Bitner ◽

Murali Gopalakrishnan ◽

Lynne E. Rueter

Keyword(s):

Mouse Model ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Antipsychotic Efficacy

Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation

Reviews in Endocrine and Metabolic Disorders ◽

10.1007/s11154-020-09584-3 ◽

2020 ◽

Vol 21 (4) ◽

pp. 431-447

Author(s):

Han Xie ◽

Natesh Yepuri ◽

Qinghe Meng ◽

Ravi Dhawan ◽

Colin A. Leech ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Therapeutic Potential ◽

Nicotinic Acetylcholine ◽

Receptor Agonists

Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates – subtype selective, high affinity α7 nicotinic acetylcholine receptor agonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.06.059 ◽

2009 ◽

Vol 19 (16) ◽

pp. 4747-4751 ◽

Cited By ~ 10

Author(s):

Christopher J. O’Donnell ◽

Langu Peng ◽

Brian T. O’Neill ◽

Eric P. Arnold ◽

Robert J. Mather ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

High Affinity ◽

Sar Studies ◽

Subtype Selective

In Vivo Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists [11C]A-582941 and [11C]A-844606 in Mice and Conscious Monkeys

PLoS ONE ◽

10.1371/journal.pone.0008961 ◽

2010 ◽

Vol 5 (2) ◽

pp. e8961 ◽

Cited By ~ 23

Author(s):

Jun Toyohara ◽

Kiichi Ishiwata ◽

Muneyuki Sakata ◽

Jin Wu ◽

Shingo Nishiyama ◽

...

Keyword(s):

Acetylcholine Receptor ◽

In Vivo Evaluation ◽

Nicotinic Acetylcholine ◽

Receptor Agonists

Gamma-lactams—A novel scaffold for highly potent and selective α7 nicotinic acetylcholine receptor agonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.01.073 ◽

2009 ◽

Vol 19 (5) ◽

pp. 1287-1291 ◽

Cited By ~ 20

Author(s):

Albert Enz ◽

Dominik Feuerbach ◽

Mathias U. Frederiksen ◽

Conrad Gentsch ◽

Konstanze Hurth ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Receptor Agonists ◽

Novel Scaffold

Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2006.09.019 ◽

2006 ◽

Vol 14 (24) ◽

pp. 8219-8248 ◽

Cited By ~ 63

Author(s):

Daniel P. Walker ◽

Donn G. Wishka ◽

David W. Piotrowski ◽

Shaojuan Jia ◽

Steven C. Reitz ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Nicotinic Acetylcholine ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity