A Yarrowia lipolytica strain engineered for arachidonic acid production counteracts metabolic burden by redirecting carbon flux towards intracellular fatty acid accumulation at the expense of organic acids secretion

2017 ◽  
Vol 128 ◽  
pp. 201-209 ◽  
Author(s):  
Hu-Hu Liu ◽  
Si-Yu Zeng ◽  
Tian-Qiong Shi ◽  
Ying Ding ◽  
Lu-Jing Ren ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Fatty Acid ◽  
Organic Acids ◽  
Yarrowia Lipolytica ◽  
Carbon Flux ◽  
Acid Production ◽  
Fatty Acid Accumulation ◽  
Arachidonic Acid Production ◽  
Acid Accumulation ◽  
Lipolytica Strain

scholarly journals Engineering Yarrowia lipolytica for arachidonic acid production through rapid assembly of metabolic pathway

2017 ◽  
Vol 119 ◽  
pp. 52-58 ◽  
Author(s):  
Hu-Hu Liu ◽  
Catherine Madzak ◽  
Mei-Li Sun ◽  
Lu-Jing Ren ◽  
Ping Song ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Yarrowia Lipolytica ◽  
Metabolic Pathway ◽  
Acid Production ◽  
Arachidonic Acid Production

Sesamin inhibits lysophosphatidyl-choline acyltransferase in Mortierella alpina

2000 ◽  
Vol 28 (6) ◽  
pp. 718-721 ◽  
Author(s):  
S. Chatrattanakunchai ◽  
T. Fraser ◽  
K. Stobart
Keyword(s):  
Arachidonic Acid ◽  
Fatty Acid ◽  
Filamentous Fungus ◽  
Acid Production ◽  
Inhibitory Effect ◽  
Mortierella Alpina ◽  
Microsomal Membrane ◽  
Lysophosphatidyl Choline ◽  
Arachidonic Acid Production ◽  
Complex Lipids

The filamentous fungus, Mortierella alpina accumulates complex lipids relatively rich in arachidonic acid (C20 4 Δ5.8.11.14). The lignan, sesamin, has been used to reduce arachidonic acid production by specifically inhibiting Δ5-desaturation [Shimizu, Akimoto, Shinmen, Kawashima, Sugano and Yamada (1991) Lipids 26, 512–516]. Microsomal membrane preparations from M. alpina exhibit acyl-CoA:1-acyl lysophosphatidylcholine acyltransferase (LPCAT) activity. LPCAT is an enzyme involved in channelling fatty acid substrates to phosphatidylcholine for subsequent desaturation. Sesamin was found to inhibit this enzyme as measured in both spectrophotometric and radioactive assays. The inhibitory effect of sesamin on LPCAT was only evident in species of Mortierella and could not be demonstrated in other organisms.

0899 Omega-3 and omega-7 oil supplementation on tissue fatty acid accumulation

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 433-433
Author(s):  
S. K. Duckett ◽  
I. F. Furusho-Garcia ◽  
M. F. Miller ◽  
B. M. Koch ◽  
G. Volpi Lagreca
Keyword(s):  
Fatty Acid ◽  
Omega 3 ◽  
Tissue Fatty Acid ◽  
Fatty Acid Accumulation ◽  
Acid Accumulation

scholarly journals Endoplasmic Reticulum-Located PDAT1-2 from Castor Bean Enhances Hydroxy Fatty Acid Accumulation in Transgenic Plants

2011 ◽  
Vol 52 (6) ◽  
pp. 983-993 ◽  
Author(s):  
Hyun Uk Kim ◽  
Kyeong-Ryeol Lee ◽  
Young Sam Go ◽  
Jin Hee Jung ◽  
Mi-Chung Suh ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Fatty Acid ◽  
Transgenic Plants ◽  
Castor Bean ◽  
Hydroxy Fatty Acid ◽  
Fatty Acid Accumulation ◽  
Acid Accumulation

Non-Photosynthetic CO2 Utilization to Increase Fatty Acid Production in Yarrowia lipolytica

2021 ◽  
Vol 69 (40) ◽  
pp. 11912-11918
Author(s):  
Seung Kyou You ◽  
Hyeon Min Park ◽  
Myeong-Eun Lee ◽  
Young Jin Ko ◽  
Dong-Hyeuk Hwang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Yarrowia Lipolytica ◽  
Acid Production ◽  
Co2 Utilization ◽  
Fatty Acid Production
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