Erratum to “Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy” [Bioact. Mater. 5 (2020) 542–552]

A feasible and biocompatible supramolecular complex self-assembled from indocyanine green (ICG) and methyl-β-cyclodextrin (Mβ-CD) was developed for targeted cancer imaging, which enhanced fluorescence-guided photothermal cancer therapy. This study confirmed that the formation of an inclusion complex of the heterocyclic ICG moiety and Mβ-CD inner cavity could result in improved tumor targetability compared with free ICG. The ICG-CD complex could be used as a bifunctional phototherapeutic agent for targeted cancer phototherapy due to the high tumor targetability of the Mβ-CD moiety and effective photothermal performance of the near-infrared (NIR) ICG moiety. Upon NIR laser irradiation, the photothermal effect exerted by the ICG-CD complex significantly enhanced the temperature at the tumor site by 56.2 °C within 5 min. Targeting HT-29 tumors using the ICG-CD complex resulted in an apparent reduction in tumor volumes over the 9 days after photothermal treatment. Moreover, no tumor recurrence or body weight loss were observed after administering a single dose of ICG-CD complex with NIR laser irradiation. Therefore, the administration of the biocompatible ICG-CD complex in combination with NIR laser treatment can be safely explored as a potential strategy for future clinical applications.

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PEGylated Polydopamine Nanoparticles Incorporated with Indocyanine Green and Doxorubicin for Magnetically Guided Multimodal Cancer Therapy Triggered by Near-Infrared Light

ACS Applied Nano Materials ◽

10.1021/acsanm.7b00176 ◽

2017 ◽

Vol 1 (1) ◽

pp. 325-336 ◽

Cited By ~ 10

Author(s):

Lihong Sun ◽

Qian Li ◽

Lei Zhang ◽

Zhigang Xu ◽

Yuejun Kang ◽

...

Keyword(s):

Cancer Therapy ◽

Indocyanine Green ◽

Near Infrared ◽

Infrared Light ◽

Near Infrared Light

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Attachable Hydrogel Containing Indocyanine Green for Selective Photothermal Therapy against Melanoma

Biomolecules ◽

10.3390/biom10081124 ◽

2020 ◽

Vol 10 (8) ◽

pp. 1124

Author(s):

Juyoung Hwang ◽

Jun-O Jin

Keyword(s):

Skin Cancer ◽

Indocyanine Green ◽

Laser Irradiation ◽

Photothermal Therapy ◽

Near Infrared ◽

Target Therapy ◽

Biocompatible Polymer ◽

Diallyldimethylammonium Chloride ◽

Nir Laser ◽

Poly Acrylamide

Melanoma is the most lethal form of skin cancer because it spreads easily to other tissues, thereby decreasing the efficiency of its treatment via chemo-, radio-, and surgical therapies. We suggest the application of an attachable hydrogel for the treatment of melanoma whereby the size and amount of incorporated indocyanine green (ICG) for photothermal therapy (PTT) can be controlled. An attachable hydrogel (poly(acrylamide-co-diallyldimethylammonium chloride); PAD) that incorporates ICG as a near-infrared (NIR) absorber was fabricated using a biocompatible polymer. The temperature of PAD-ICG increases under 808 nm laser irradiation. The hydrogel protects the ICG against decomposition; consequently, PAD-ICG can be reused for PTT. The attachment of PAD-ICG to an area with melanoma in mice, with irradiation using a NIR laser, successfully eliminated melanoma. Thus, the data suggest that PAD-ICG is a smart material that could be used for selective target therapy against melanoma in humans.

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NDs@PDA@ICG Conjugates for Photothermal Therapy of Glioblastoma Multiforme

Biomimetics ◽

10.3390/biomimetics4010003 ◽

2019 ◽

Vol 4 (1) ◽

pp. 3 ◽

Cited By ~ 11

Author(s):

Damian Maziukiewicz ◽

Bartosz Grześkowiak ◽

Emerson Coy ◽

Stefan Jurga ◽

Radosław Mrówczyński

Keyword(s):

Glioblastoma Multiforme ◽

Cancer Therapy ◽

Brain Tumors ◽

Indocyanine Green ◽

Photothermal Therapy ◽

Near Infrared ◽

Survival Rates ◽

Modern Medicine ◽

New Ideas

The growing incidence of cancer is a problem for modern medicine, since the therapeutic efficacy of applied modalities is still not satisfactory in terms of patients’ survival rates, especially in the case of patients with brain tumors. The destructive influence of chemotherapy and radiotherapy on healthy cells reduces the chances of full recovery. With the development of nanotechnology, new ideas on cancer therapy, including brain tumors, have emerged. Photothermal therapy (PTT) is one of these. It utilizes nanoparticles (NPs) that can convert the light, preferably in the near-infrared (NIR) region, into heat. In this paper, we report the use of nanodiamonds (NDs) conjugated with biomimetic polydopamine (PDA) and indocyanine green (ICG) for glioblastoma cancer PTT therapy. The obtained materials were thoroughly analyzed in terms of their PTT effectiveness, as well as their physicochemical properties. The performed research demonstrated that NDs@PDA@ICG can be successfully applied in the photothermal therapy of glioblastoma for PTT and exhibited high photothermal conversion efficiency η above 40%, which is almost 10 times higher than in case of bare NDs. In regard to our results, our material was found to lead to a better therapeutic outcome and higher eradication of glioblastoma cells, as demonstrated in vitro.

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