Corrigendum to “The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4” [Int J Biochem Cell Biol, 2018, Sep, 102, 151–160]

Despite the established role of integrin β4 (ITG β4) in breast cancer progression, the importance of endocytic recycling of ITG β4 and its regulatory mechanism are poorly understood. Here, we found that a sub-population of ITG β4 is sorted into early endosomes, recycled back to the plasma membrane, and secreted in the form of extracellular vesicles (EVs) upon EGF treatment in triple negative breast cancer (TNBC) cells. A metastasis suppressor, ARRDC3 (arrestin domain-containing 3) prevents EGF-driven endocytic recycling of ITG β4 by inducing NEDD4-dependent ubiquitination of ITG β4 and targeting endosomal ITG β4 into lysosomes. Endocytic recycling of ITG β4 is linked to sorting of ITG β4 into EVs (ITG β4+ EVs). ITG β4+ EVs are mainly detectable from supernatants of TNBC cells and their production is inhibited by ARRDC3 expression. ARRDC3 reduces the metastatic potentials of breast cancer cell-derived EVs by reducing ITG β4 levels in EVs. Overall, current studies provide novel mechanistic insights on the regulatory mechanism of ITG β4 recycling, and its importance in invasive potentials of TNBC EVs, thus providing the basis for therapeutic targeting of the ARRDC3/ITG β4 pathway in TNBC.

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Invasive breast cancer induces laminin-332 upregulation and integrin β4 neoexpression in myofibroblasts to confer an anoikis-resistant phenotype during tissue remodeling

Breast Cancer Research ◽

10.1186/bcr3203 ◽

2012 ◽

Vol 14 (3) ◽

Cited By ~ 27

Author(s):

Baek Gil Kim ◽

Ming-Qing Gao ◽

Yoon Pyo Choi ◽

Suki Kang ◽

Haeng Ran Park ◽

...

Keyword(s):

Breast Cancer ◽

Invasive Breast Cancer ◽

Tissue Remodeling ◽

Resistant Phenotype ◽

Integrin Β4 ◽

Laminin 332

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The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-β4

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2018.07.011 ◽

2018 ◽

Vol 102 ◽

pp. 151-160 ◽

Cited By ~ 9

Author(s):

Sumit Siddharth ◽

Anmada Nayak ◽

Sarita Das ◽

Deepika Nayak ◽

Jyochanamayi Panda ◽

...

Keyword(s):

Breast Cancer ◽

Integrin Β4

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Corrigendum to “CBX4 exhibits oncogenic activities in breast cancer via Notch1 signaling” [Int. J. Biochem. Cell Biol. (2018) 1–8]

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2018.10.001 ◽

2018 ◽

Vol 105 ◽

pp. 145

Author(s):

Jin-Sheng Zeng ◽

Zhen-Dong Zhang ◽

Li Pei ◽

Zhi-Zhu Bai ◽

Yong Yang ◽

...

Keyword(s):

Breast Cancer ◽

Notch1 Signaling ◽

Cell Biol

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Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells

PLoS ONE ◽

10.1371/journal.pone.0125399 ◽

2015 ◽

Vol 10 (5) ◽

pp. e0125399 ◽

Cited By ~ 16

Author(s):

David T. Coleman ◽

Young Hwa Soung ◽

Young-Joon Surh ◽

James A. Cardelli ◽

Jun Chung

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Integrin Β4

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Rewired Notch/p53 by Numb’ing Mdm2

The Journal of Cell Biology ◽

10.1083/jcb.201712007 ◽

2018 ◽

Vol 217 (2) ◽

pp. 445-446 ◽

Cited By ~ 4

Author(s):

Hyungsoo Kim ◽

Ze’ev A. Ronai

Keyword(s):

Breast Cancer ◽

Tumor Suppressor ◽

Therapeutic Intervention ◽

Splice Variant ◽

Tumor Suppressor Protein ◽

Tumor Suppressor Protein P53 ◽

Protein P53 ◽

Cell Biol ◽

Coordinated Regulation

Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53–Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709092) reveal an unexpected role of a newly characterized Numb splice variant in the regulation of p53, which may have significant implications for therapeutic intervention in breast cancer.

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