Development and characterisation of molecularly imprinted polymers based on methacrylic acid for selective recognition of drugs

Biomaterials ◽  
2007 ◽  
Vol 28 (25) ◽  
pp. 3741-3749 ◽  
Author(s):  
Xizhi Shi ◽  
Aibo Wu ◽  
Guorun Qu ◽  
Rongxiu Li ◽  
Dabing Zhang
Keyword(s):  
Methacrylic Acid ◽  
Molecularly Imprinted Polymers ◽  
Selective Recognition ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals Selective recognition of methotrexate by molecularly imprinted polymers

e-Polymers ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Manuela Curcio ◽  
Ortensia Ilaria Parisi ◽  
Giuseppe Cirillo ◽  
Umile Gianfranco Spizzirri ◽  
Francesco Puoci ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Functional Groups ◽  
Methacrylic Acid ◽  
Molecularly Imprinted Polymers ◽  
High Selectivity ◽  
Selective Recognition ◽  
Template Molecule ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers

AbstractThe aim of this study is the preparation of molecularly imprinted polymers with high selectivity for metotrexate (MTX), a useful antineoplastic drug widely employed in clinical trials. Methacrylic acid, 2-(dimethylamino)ethyl methacrylate and a mixture of them were tested as functional monomers in order to optimize the performance of imprinted materials. The specificity and the selectivity of imprinted polymers was tested by performing rebinding experiments in water at pH 7.4. The best results were obtained by employing both functional monomers in the polymeric feed. In this way, each monomer interacts with complementary functionalities on template molecule, stabilizing the prepolymerization complex and minimizing the repulsive effects (due to the ionization of functional groups) in the rebinding media.

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