The role of oxidation and enzymatic hydrolysis on the in vivo degradation of trimethylene carbonate based photocrosslinkable elastomers

Biomaterials ◽  
2009 ◽  
Vol 30 (3) ◽  
pp. 295-306 ◽  
Author(s):  
Rafi Chapanian ◽  
M. Yat Tse ◽  
Stephen C. Pang ◽  
Brian G. Amsden
Keyword(s):  
Enzymatic Hydrolysis ◽  
Trimethylene Carbonate ◽  
In Vivo Degradation

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Amphiphilic Copolymers for Long-Acting Injectables: Synthesis, Non-Acylating Performance and In Vivo Degradation

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1438
Author(s):  
Silvio Curia ◽  
Feifei Ng ◽  
Marie-Emérentienne Cagnon ◽  
Victor Nicoulin ◽  
Adolfo Lopez-Noriega
Keyword(s):  
Ethylene Glycol ◽  
Ring Opening ◽  
Gel Chromatography ◽  
Amphiphilic Copolymers ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Acting ◽  
In Vivo Degradation

This article presents the evaluation of diblock and triblock poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) amphiphilic copolymers (PEG-PTMCs) as excipients for the formulation of long-acting injectables (LAIs). Copolymers were successfully synthesised through bulk ring-opening polymerisation. The concomitant formation of PTMC homopolymer could not be avoided irrespective of the catalyst amount, but the by-product could easily be removed by gel chromatography. Pure PEG-PTMCs undergo faster erosion in vivo than their corresponding homopolymer. Furthermore, these copolymers show outstanding stability compared to their polyester analogues when formulated with amine-containing reactive drugs, which makes them particularly suitable as LAIs for the sustained release of drugs susceptible to acylation.

scholarly journals Instability of CII is needed for efficient switching between lytic and lysogenic development in bacteriophage 186

2020 ◽  
Vol 48 (21) ◽  
pp. 12030-12041
Author(s):  
Iain M Murchland ◽  
Alexandra Ahlgren-Berg ◽  
Julian M J Pietsch ◽  
Alejandra Isabel ◽  
Ian B Dodd ◽  
...  
Keyword(s):  
Stochastic Model ◽  
Transcriptional Activator ◽  
Uv Treatment ◽  
Prophage Induction ◽  
In Vivo Degradation

Abstract The CII protein of temperate coliphage 186, like the unrelated CII protein of phage λ, is a transcriptional activator that primes expression of the CI immunity repressor and is critical for efficient establishment of lysogeny. 186-CII is also highly unstable, and we show that in vivo degradation is mediated by both FtsH and RseP. We investigated the role of CII instability by constructing a 186 phage encoding a protease resistant CII. The stabilised-CII phage was defective in the lysis-lysogeny decision: choosing lysogeny with close to 100% frequency after infection, and forming prophages that were defective in entering lytic development after UV treatment. While lysogenic CI concentration was unaffected by CII stabilisation, lysogenic transcription and CI expression was elevated after UV. A stochastic model of the 186 network after infection indicated that an unstable CII allowed a rapid increase in CI expression without a large overshoot of the lysogenic level, suggesting that instability enables a decisive commitment to lysogeny with a rapid attainment of sensitivity to prophage induction.

Anomalous in Vitro and in Vivo Degradation of Magnesium Phosphate Bioceramics: Role of Zinc Addition

2019 ◽  
Vol 5 (10) ◽  
pp. 5097-5106 ◽  
Author(s):  
Kaushik Sarkar ◽  
Vinod Kumar ◽  
K. Bavya Devi ◽  
Debaki Ghosh ◽  
Samit Kumar Nandi ◽  
...  
Keyword(s):  
Magnesium Phosphate ◽  
Zinc Addition ◽  
In Vivo Degradation

scholarly journals The in Vitro and in Vivo Degradation of Cross-Linked Poly(trimethylene carbonate)-Based Networks

Polymers ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 151 ◽  
Author(s):  
Liqun Yang ◽  
Jianxin Li ◽  
Miao Li ◽  
Zhongwei Gu
Keyword(s):  
Trimethylene Carbonate ◽  
In Vivo Degradation

The in vitro and in vivo degradation behavior of poly (trimethylene carbonate-co-ε-caprolactone) implants

Polymer ◽  
2014 ◽  
Vol 55 (20) ◽  
pp. 5111-5124 ◽  
Author(s):  
Liqun Yang ◽  
Jianxin Li ◽  
Shu Meng ◽  
Ying Jin ◽  
Jinzhe Zhang ◽  
...  
Keyword(s):  
Degradation Behavior ◽  
Trimethylene Carbonate ◽  
In Vivo Degradation
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