In vitro and in vivo degradation behavior of poly(trimethylene carbonate-co-d,l-lactic acid) copolymer

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

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The in vivo and in vitro degradation behavior of poly(trimethylene carbonate)

Biomaterials ◽

10.1016/j.biomaterials.2005.09.017 ◽

2006 ◽

Vol 27 (9) ◽

pp. 1741-1748 ◽

Cited By ~ 273

Author(s):

Zheng Zhang ◽

Roel Kuijer ◽

Sjoerd K. Bulstra ◽

Dirk W. Grijpma ◽

Jan Feijen

Keyword(s):

Degradation Behavior ◽

Trimethylene Carbonate ◽

In Vitro Degradation

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In vitro and in vivo degradation of lactic acid-based interference screws used in cruciate ligament reconstruction

International Journal of Biological Macromolecules ◽

10.1016/s0141-8130(99)00043-4 ◽

1999 ◽

Vol 25 (1-3) ◽

pp. 283-291 ◽

Cited By ~ 72

Author(s):

G. Schwach ◽

M. Vert

Keyword(s):

Lactic Acid ◽

Ligament Reconstruction ◽

Cruciate Ligament ◽

Interference Screws ◽

Cruciate Ligament Reconstruction ◽

In Vivo Degradation

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In vivo degradation behavior of enzyme-degradable poly(trimethylene carbonate)-based biohybrid networks of varying water content

Biomedical Materials ◽

10.1088/1748-605x/ab62ff ◽

2020 ◽

Vol 15 (2) ◽

pp. 025001

Author(s):

Shadi Taghavi ◽

Brian G Amsden

Keyword(s):

Water Content ◽

Degradation Behavior ◽

Trimethylene Carbonate ◽

In Vivo Degradation

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In vivo degradation behavior of PDC multiblock copolymers containing poly(para-dioxanone) hard segments and crystallizable poly(epsilon-caprolactone) switching segments

MRS Proceedings ◽

10.1557/proc-1190-nn06-05 ◽

2009 ◽

Vol 1190 ◽

Cited By ~ 3

Author(s):

Bernhard Hiebl ◽

Karl Kratz ◽

Rosemarie Fuhrmann ◽

Friedrich Jung ◽

Andres Lendlein ◽

...

Keyword(s):

Enzymatic Degradation ◽

Degradation Products ◽

In Vivo Studies ◽

Multiblock Copolymers ◽

Degradation Behavior ◽

Hard Segments ◽

In Vivo Degradation ◽

Good Agreement

AbstractThe degradation behavior of biodegradable multiblock copolymers (PDC) containing poly(p-dioxanone) hard segments (PPDO) and crystallizable poly(epsilon-caprolactone) switching segments (PCL) synthesized via co-condensation of two oligomeric macrodiols with an aliphatic diisocyanate as junction unit was explored in in vivo and in vitro experiments. The in vitro experiments for enzymatic degradation resulted that the poly(epsilon-caprolactone) segments are degraded faster, than the poly(p-dioxanone) segments. During degradation the outer layer of the test specimen becomes porous. Finally non-soluble degradation products in form of particles were found at the surface. This observation is in good agreement with the in vivo studies, where the non-soluble degradation products in the periimplantary tissues showed a diameter of 1 – 3 micron.

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Development of a membrane of poly (L-co-D,L lactic acid-co-trimethylene carbonate) with aloe vera: An alternative biomaterial designed to improve skin healing

Journal of Biomaterials Applications ◽

10.1177/0885328217719854 ◽

2017 ◽

Vol 32 (3) ◽

pp. 311-320 ◽

Cited By ~ 7

Author(s):

Daniel Komatsu ◽

Daniel V Mistura ◽

Adriana Motta ◽

Juliana A Domingues ◽

Moema A Hausen ◽

...

Keyword(s):

Lactic Acid ◽

Healing Process ◽

Aloe Vera ◽

Life Quality ◽

Tensile Tests ◽

Sem Analysis ◽

Mitochondrial Activity ◽

Trimethylene Carbonate

The search for new therapies and drugs that act as topical agents to relieve pain and control the infectious processes in burns always attracted interest in clinical trials. As an alternative to synthetic drugs, the use of natural extracts is useful in the development of new strategies and formulations for improving the life quality. The aim of this study was to develop a wound dressing using Poly(L-co-D,L lactic acid-co-TMC) (PLDLA-co-TMC) containing aloe vera (AV). This natural plant extract is known for its modulatory effects under healing process. The membrane of PLDLA-co-TMC+aloe vera was prepared at different concentrations of AV (5, 10, 15 and 50%). The FTIR showed no change in the PLDLA-co-TMC spectrum after AV addition, while the swelling test showed changes only in PLDLA-co-TMC+AV at 50%. The wettability measurements showed decrease in the contact angle in all samples after the AV addition in the polymer, while the AV release test showed that PLDLA-co-TMC+50%AV sample has higher AV release rate than the sample with other AV concentrations. The SEM analysis showed that AV was homogeneously distributed at 5% only. Tensile tests demonstrated an increase in the Young's modulus and a reduction in the elongation till rupture of the PLDLA-co-TMC after the addition of AV. Biocompatibility in vitro evaluation with fibroblast cells seeded in the membranes of PLDLA-co-TMC+AV showed that the cells were able to adhere, proliferate and maintain mitochondrial activity in all AV concentrations tested. Due to the known skin medicinal properties attributed to AV and the results here obtained, we suggest that after in vivo trials, the PLDLA-co-TMC+AV should be a promising biomaterial for application as a device for skin curative and healing agent.

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Biodegradable 3D Printed Scaffolds of Modified Poly (Trimethylene Carbonate) Composite Materials with Poly (L-Lactic Acid) and Hydroxyapatite for Bone Regeneration

Nanomaterials ◽

10.3390/nano11123215 ◽

2021 ◽

Vol 11 (12) ◽

pp. 3215

Author(s):

Honglei Kang ◽

Xudong Jiang ◽

Zhiwei Liu ◽

Fan Liu ◽

Guoping Yan ◽

...

Keyword(s):

Lactic Acid ◽

Composite Materials ◽

Polymeric Materials ◽

Bone Cell ◽

Cell Multiplication ◽

X Rays ◽

Trimethylene Carbonate ◽

Scanning Calorimetry

Biodegradable scaffolds based on biomedical polymeric materials have attracted wide interest in bone transplantation for clinical treatment for bone defects without a second operation. The composite materials of poly(trimethylene carbonate), poly(L-lactic acid), and hydroxyapatite (PTMC/PLA/HA and PTMC/HA) were prepared by the modification and blending of PTMC with PLA and HA, respectively. The PTMC/PLA/HA and PTMC/HA scaffolds were further prepared by additive manufacturing using the biological 3D printing method using the PTMC/PLA/HA and PTMC/HA composite materials, respectively. These scaffolds were also characterized by Fourier transform infrared spectroscopy (FT-IR), gel permeation chromatography (GPC), automatic contact-angle, scanning electronic micrographs (SEM), diffraction of X-rays (XRD), differential scanning calorimetry (DSC), and thermogravimetry (TG). Subsequently, their properties, such as mechanical, biodegradation, cell cytotoxicity, cell compatibility in vitro, and proliferation/differentiation assay in vivo, were also investigated. Experiment results indicated that PTMC/PLA/HA and PTMC/HA scaffolds possessed low toxicity, good biodegradability, and good biocompatibility and then enhanced the cell multiplication ability of osteoblast cells (MC3T3-E1). Moreover, PTMC/PLA/HA and PTMC/HA scaffolds enhanced the adhesion and proliferation of MC3T3-E1 cells and enabled the bone cell proliferation and induction of bone tissue formation. Therefore, these composite materials can be used as potential biomaterials for bone repatriation and tissue engineering.

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