Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel

Biomaterials ◽  
2012 ◽  
Vol 33 (7) ◽  
pp. 2310-2320 ◽  
Author(s):  
Jing Li ◽  
Meirong Huo ◽  
Jing Wang ◽  
Jianping Zhou ◽  
Jumah M. Mohammad ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Deoxycholic Acid ◽  
Intracellular Delivery ◽  
Self Assembled

scholarly journals Preparation and Characterization of Self-Assembled Nanoparticles of Hyaluronic Acid-Deoxycholic Acid Conjugates

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Xuemeng Dong ◽  
Chenguang Liu
Keyword(s):  
Hyaluronic Acid ◽  
Deoxycholic Acid ◽  
Structural Characteristics ◽  
Cetylpyridinium Chloride ◽  
Coupling Reaction ◽  
Critical Aggregation Concentration ◽  
Transmission Electron ◽  
Fluorescence Quenching Method ◽  
Self Assembled ◽  
Quenching Method

Novel amphiphilic biopolymers were synthesized using hyaluronic acid (HA) as a hydrophilic segment and deoxycholic acid (DOCA) as a hydrophobic segment by a 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide mediated coupling reaction. The structural characteristics of the HA-DOCA conjugates were investigated usingH1NMR. Self-assembled nanoparticles were prepared based on HA-DOCA conjugates, and its characteristics were investigated using dynamic laser light scattering, transmission electron microscopy (TEM), and fluorescence spectroscopy. The mean diameter was about 293.5 nm with unimodal size distribution in distilled water. The TEM images revealed that the shape of HA-DOCA self-aggregates was spherical. The critical aggregation concentration (CAC) was in the range of 0.025–0.056 mg/mL. The partition equilibrium constant (Kv) of pyrene in self-aggregates solution was from1.45×104to3.64×104. The aggregation number of DOCA groups per hydrophobic microdomain, estimated by the fluorescence quenching method using cetylpyridinium chloride, increased with increasing degree of substitution.

Self-assembled pH-responsive hyaluronic acid–g-poly(l-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin

2014 ◽  
Vol 10 (5) ◽  
pp. 2024-2035 ◽  
Author(s):  
Lipeng Qiu ◽  
Zhen Li ◽  
Mingxi Qiao ◽  
Miaomiao Long ◽  
Mingyue Wang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Intracellular Delivery ◽  
Ph Responsive ◽  
Copolymer Micelles ◽  
Self Assembled

Self-Assembled Hyaluronic Acid Nanoparticles for Osteoarthritis Treatment

Biomaterials ◽  
2021 ◽  
pp. 120967
Author(s):  
Li-Jung Kang ◽  
Juhwan Yoon ◽  
Jun Gi Rho ◽  
Hwa Seung Han ◽  
Seulbi Lee ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Osteoarthritis Treatment ◽  
Self Assembled

scholarly journals Self-Assembled Quantum Dot−Peptide Bioconjugates for Selective Intracellular Delivery

2006 ◽  
Vol 17 (4) ◽  
pp. 920-927 ◽  
Author(s):  
James B. Delehanty ◽  
Igor L. Medintz ◽  
Thomas Pons ◽  
Florence M. Brunel ◽  
Philip E. Dawson ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Intracellular Delivery ◽  
Self Assembled

Optimization of the Conditions for Plasmid DNA Delivery and Transfection with Self-Assembled Hyaluronic Acid-Based Nanoparticles

2018 ◽  
Vol 16 (1) ◽  
pp. 128-140 ◽  
Author(s):  
Hibah M Aldawsari ◽  
Harkiranpreet Kaur Dhaliwal ◽  
Bader Mubarak Aljaeid ◽  
Nabil A. Alhakamy ◽  
Zainy Mohammad Banjar ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Plasmid Dna ◽  
Dna Delivery ◽  
Self Assembled

pH- and GSH-Sensitive Hyaluronic Acid-MP Conjugate Micelles for Intracellular Delivery of Doxorubicin to Colon Cancer Cells and Cancer Stem Cells

2018 ◽  
Vol 19 (9) ◽  
pp. 3725-3737 ◽  
Author(s):  
Tilahun Ayane Debele ◽  
Lu-Yi Yu ◽  
Cheng-Sheng Yang ◽  
Yao-An Shen ◽  
Chun-Liang Lo
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Cancer Stem Cells ◽  
Cancer Cells ◽  
Intracellular Delivery ◽  
Colon Cancer Cells

scholarly journals Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ana Cadete ◽  
Ana Olivera ◽  
Magnus Besev ◽  
Pradeep K. Dhal ◽  
Lídia Gonçalves ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Intracellular Delivery ◽  
Self Assembled

Self-assembled hyaluronic acid nanoparticles for active tumor targeting

Biomaterials ◽  
2010 ◽  
Vol 31 (1) ◽  
pp. 106-114 ◽  
Author(s):  
Ki Young Choi ◽  
Hyunjin Chung ◽  
Kyung Hyun Min ◽  
Hong Yeol Yoon ◽  
Kwangmeyung Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Tumor Targeting ◽  
Self Assembled
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