Manipulating the surface coating of ultra-small Gd2O3 nanoparticles for improved T1-weighted MR imaging

Biomaterials ◽  
2014 ◽  
Vol 35 (5) ◽  
pp. 1636-1642 ◽  
Author(s):  
Jie Fang ◽  
Prashant Chandrasekharan ◽  
Xiao-Li Liu ◽  
Yong Yang ◽  
Yun-Bo Lv ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Surface Coating ◽  
Gd2o3 Nanoparticles

scholarly journals Hydrophilic Biocompatible Poly(Acrylic Acid-co-Maleic Acid) Polymer as a Surface-Coating Ligand of Ultrasmall Gd2O3 Nanoparticles to Obtain a High r1 Value and T1 MR Images

Diagnostics ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 2
Author(s):  
Yeong-Ji Jang ◽  
Shuwen Liu ◽  
Huan Yue ◽  
Ji Ae Park ◽  
Hyunsil Cha ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Contrast Agents ◽  
Maleic Acid ◽  
Surface Coating ◽  
Colloidal Stability ◽  
Proton Spin ◽  
Water Proton ◽  
Mr Images ◽  
Mri Contrast ◽  
Gd2o3 Nanoparticles

The water proton spin relaxivity, colloidal stability, and biocompatibility of nanoparticle-based magnetic resonance imaging (MRI) contrast agents depend on the surface-coating ligands. Here, poly(acrylic acid-co-maleic acid) (PAAMA) (Mw = ~3000 amu) is explored as a surface-coating ligand of ultrasmall gadolinium oxide (Gd2O3) nanoparticles. Owing to the numerous carboxylic groups in PAAMA, which allow its strong conjugation with the nanoparticle surfaces and the attraction of abundant water molecules to the nanoparticles, the synthesized PAAMA-coated ultrasmall Gd2O3 nanoparticles (davg = 1.8 nm and aavg = 9.0 nm) exhibit excellent colloidal stability, extremely low cellular toxicity, and a high longitudinal water proton spin relaxivity (r1) of 40.6 s−1mM−1 (r2/r1 = 1.56, where r2 = transverse water proton spin relaxivity), which is approximately 10 times higher than those of commercial molecular contrast agents. The effectiveness of PAAMA-coated ultrasmall Gd2O3 nanoparticles as a T1 MRI contrast agent is confirmed by the high positive contrast enhancements of the in vivo T1 MR images at the 3.0 T MR field.

Contribution of MR imaging and CEA cystic fluid level to the differential diagnosis of cystic lesions of the pancreas

2001 ◽  
Vol 120 (5) ◽  
pp. A764-A764
Author(s):  
M DELHAYE ◽  
C WINANT ◽  
D DEGRE ◽  
B GULBIS ◽  
C GERVY ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Mr Imaging ◽  
Cystic Lesions ◽  
Fluid Level ◽  
Cystic Fluid
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