Amide side chain amphiphilic polymers disrupt surface established bacterial bio-films and protect mice from chronic Acinetobacter baumannii infection

It has been shown that the thermodynamics of bicontinuous microemulsions can be tailored via the addition of various different amphiphilic polymers. In this manuscript, we now focus on comb-type polymers consisting of hydrophobic backbones and hydrophilic side chains. The distinct philicity of the backbone and side chains leads to a well-defined segregation into the oil and water domains respectively, as confirmed by contrast variation small-angle neutron scattering experiments. This polymer–microemulsion structure leads to well-described conformational entropies of the polymer fragments (backbone and side chains) that exert pressure on the membrane, which influences the thermodynamics of the overall microemulsion. In the context of the different polymer architectures that have been studied by our group with regards to their phase diagrams and small-angle neutron scattering, the microemulsion thermodynamics of comb polymers can be described in terms of a superposition of the backbone and side chain fragments. The denser or longer the side chain, the stronger the grafting and the more visible the brush effect of the side chains becomes. Possible applications of the comb polymers as switchable additives are discussed. Finally, a balanced philicity of polymers also motivates transmembrane migration in biological systems of the polymers themselves or of polymer–DNA complexes.

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Characterization of Aromatic−Amide(Side-Chain) Interactions in Proteins through Systematic ab Initio Calculations and Data Mining Analyses

The Journal of Physical Chemistry A ◽

10.1021/jp993381f ◽

2000 ◽

Vol 104 (19) ◽

pp. 4521-4532 ◽

Cited By ~ 45

Author(s):

Guilin Duan ◽

Vedene H. Smith, ◽

Donald F. Weaver

Keyword(s):

Data Mining ◽

Ab Initio Calculations ◽

Ab Initio ◽

Side Chain ◽

Aromatic Amide ◽

Amide Side Chain

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On the turn-inducing properties of asparagine: the structuring role of the amide side chain, from isolated model peptides to crystallized proteins

Physical Chemistry Chemical Physics ◽

10.1039/c7cp07605c ◽

2018 ◽

Vol 20 (5) ◽

pp. 3411-3423 ◽

Cited By ~ 6

Author(s):

S. Habka ◽

W. Y. Sohn ◽

V. Vaquero-Vara ◽

M. Géléoc ◽

B. Tardivel ◽

...

Keyword(s):

Gas Phase ◽

Laser Spectroscopy ◽

Protein Structures ◽

Side Chain ◽

Amide Side Chain ◽

Model Peptides

The anchoring properties of an asparagine (Asn) residue to its local backbone environment in turn model peptides is characterized using gas phase laser spectroscopy and compared to crystallized protein structures.

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Radioimmunoassay of lysergic acid diethylamide (LSD) in serum and urine by using antisera of different specificities.

Clinical Chemistry ◽

10.1093/clinchem/23.2.169 ◽

1977 ◽

Vol 23 (2) ◽

pp. 169-174 ◽

Cited By ~ 20

Author(s):

W A Ratcliffe ◽

S M Fletcher ◽

A C Moffat ◽

J G Ratcliffe ◽

W A Harland ◽

...

Keyword(s):

Biological Fluids ◽

Cross Reactivity ◽

High Titre ◽

Lysergic Acid ◽

Side Chain ◽

Satisfactory Method ◽

Related Compounds ◽

Amide Side Chain ◽

Different Parts ◽

Serum And Urine

Abstract We raised high-titre antisera to two LSD-bovine serum albumin conjugates, one linked via the indole nitrogen, the other via the amide side-chain. The antisera were specific for different parts of the LSD molecule, as demonstrated by cross-reactivity studies with LSD, its metabolites, ergot alkoloids, and closely related compounds. The antisera were used to develop a double-antibody radioimmunoassay with a detection limit of about 0.4 mug of LSD per liter of unextracted urine or serum. We saw no nonspecific interference by urine, serum, or from a series of commonly used drugs. There was good correlation between immunoassay values obtained with the two antisera (r = 0.91). However, the antiserum linked via the indole nitrogen gave consistently higher results for samples from persons who had taken LSD, owing to greater cross-reactivity with LSD metabolites. Radioimmunoassay by use of two such antisera is a more specific screening procedure for LSD abuse than has been available previously. In addition, antisera cross-reacting with LSD metabolites allow measurement of these compounds, for which there is no satisfactory method at the concentrations found in biological fluids in man.

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Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2012.02.082 ◽

2012 ◽

Vol 22 (8) ◽

pp. 2775-2779 ◽

Cited By ~ 5

Author(s):

Hiroshi Nagase ◽

Junko Akiyama ◽

Ryo Nakajima ◽

Shigeto Hirayama ◽

Toru Nemoto ◽

...

Keyword(s):

Side Chain ◽

Amide Side Chain

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2,2′-(Diselane-1,2-diyl)bis(N,N-dimethylnicotinamide)

IUCrData ◽

10.1107/s2414314617008823 ◽

2017 ◽

Vol 2 (6) ◽

Cited By ~ 2

Author(s):

Zhiqiang Guo ◽

Yakong Wang ◽

Ying Xu ◽

Xuehong Wei

Keyword(s):

Dihedral Angle ◽

Title Compound ◽

Pyridine Ring ◽

Side Chain ◽

Compound C ◽

Amide Side Chain

The title compound, C16H18N4O2Se2, is centrosymmetric. The dihedral angle between the pyridine ring and the amide side chain is 56.20 (16)°. In the crystal, a weak C—H...O interaction links the molecules into [010] chains.

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