scholarly journals Effect of tissue microenvironment on fibrous capsule formation to biomaterial-coated implants

Biomaterials ◽  
2021 ◽  
Vol 273 ◽  
pp. 120806
Author(s):  
Jamie L. Hernandez ◽  
Jaehyung Park ◽  
Shan Yao ◽  
Anna K. Blakney ◽  
Hienschi V. Nguyen ◽  
...  
Keyword(s):  
Fibrous Capsule ◽  
Capsule Formation ◽  
Tissue Microenvironment ◽  
Fibrous Capsule Formation

scholarly journals High-strength and fibrous capsule–resistant zwitterionic elastomers

2021 ◽  
Vol 7 (1) ◽  
pp. eabc5442
Author(s):  
Dianyu Dong ◽  
Caroline Tsao ◽  
Hsiang-Chieh Hung ◽  
Fanglian Yao ◽  
Chenjue Tang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
High Strength ◽  
Design Principles ◽  
Fibrous Capsule ◽  
High Mechanical Strength ◽  
Capsule Formation ◽  
Locking Mechanism ◽  
Fibrous Capsule Formation

The high mechanical strength and long-term resistance to the fibrous capsule formation are two major challenges for implantable materials. Unfortunately, these two distinct properties do not come together and instead compromise each other. Here, we report a unique class of materials by integrating two weak zwitterionic hydrogels into an elastomer-like high-strength pure zwitterionic hydrogel via a “swelling” and “locking” mechanism. These zwitterionic-elastomeric-networked (ZEN) hydrogels are further shown to efficaciously resist the fibrous capsule formation upon implantation in mice for up to 1 year. Such materials with both high mechanical properties and long-term fibrous capsule resistance have never been achieved before. This work not only demonstrates a class of durable and fibrous capsule–resistant materials but also provides design principles for zwitterionic elastomeric hydrogels.

Effect of fibrous capsule formation on doxorubicin distribution in radiofrequency ablated rat livers

2004 ◽  
Vol 69A (3) ◽  
pp. 398-406 ◽  
Author(s):  
Elvin Blanco ◽  
Feng Qian ◽  
Brent Weinberg ◽  
Nicholas Stowe ◽  
James M. Anderson ◽  
...  
Keyword(s):  
Fibrous Capsule ◽  
Capsule Formation ◽  
Rat Livers ◽  
Fibrous Capsule Formation
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