scholarly journals High-strength and fibrous capsule–resistant zwitterionic elastomers

2021 ◽  
Vol 7 (1) ◽  
pp. eabc5442
Author(s):  
Dianyu Dong ◽  
Caroline Tsao ◽  
Hsiang-Chieh Hung ◽  
Fanglian Yao ◽  
Chenjue Tang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
High Strength ◽  
Design Principles ◽  
Fibrous Capsule ◽  
High Mechanical Strength ◽  
Capsule Formation ◽  
Locking Mechanism ◽  
Fibrous Capsule Formation

The high mechanical strength and long-term resistance to the fibrous capsule formation are two major challenges for implantable materials. Unfortunately, these two distinct properties do not come together and instead compromise each other. Here, we report a unique class of materials by integrating two weak zwitterionic hydrogels into an elastomer-like high-strength pure zwitterionic hydrogel via a “swelling” and “locking” mechanism. These zwitterionic-elastomeric-networked (ZEN) hydrogels are further shown to efficaciously resist the fibrous capsule formation upon implantation in mice for up to 1 year. Such materials with both high mechanical properties and long-term fibrous capsule resistance have never been achieved before. This work not only demonstrates a class of durable and fibrous capsule–resistant materials but also provides design principles for zwitterionic elastomeric hydrogels.

scholarly journals Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated siRNA gene silencing

2013 ◽  
Vol 9 (1) ◽  
pp. 4513-4524 ◽  
Author(s):  
Pim-on Rujitanaroj ◽  
Brian Jao ◽  
Junghoon Yang ◽  
Feng Wang ◽  
James M. Anderson ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Collagen Type ◽  
Collagen Type I ◽  
Fibrous Capsule ◽  
Type I ◽  
Down Regulation ◽  
Capsule Formation ◽  
Fibrous Capsule Formation

Network structure and compositional effects on tensile mechanical properties of hydrophobic association hydrogels with high mechanical strength

Polymer ◽  
2010 ◽  
Vol 51 (6) ◽  
pp. 1507-1515 ◽  
Author(s):  
Guoqing Jiang ◽  
Chang Liu ◽  
Xiaoli Liu ◽  
Qingrui Chen ◽  
Guohui Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Network Structure ◽  
Hydrophobic Association ◽  
High Mechanical Strength ◽  
Compositional Effects

A room-temperature self-healing elastomer with ultra-high strength and toughness fabricated via optimized hierarchical hydrogen-bonding interactions

2022 ◽  
Author(s):  
Liangliang Xia ◽  
Ming Zhou ◽  
Hongjun Tu ◽  
wen Zeng ◽  
xiaoling Yang ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Mechanical Strength ◽  
Room Temperature ◽  
Polymeric Materials ◽  
High Strength ◽  
Self Healing ◽  
High Mechanical Strength ◽  
Hydrogen Bonding Interactions ◽  
Healing Efficiency ◽  
Good Healing

The preparation of room-temperature self-healing polymeric materials with good healing efficiency and high mechanical strength is challenging. Two processes are essential to realise the room-temperature self-healing of materials: (a) a...

A novel biocompatible double network hydrogel consisting of konjac glucomannan with high mechanical strength and ability to be freely shaped

2015 ◽  
Vol 3 (9) ◽  
pp. 1769-1778 ◽  
Author(s):  
Zhiyong Li ◽  
Yunlan Su ◽  
Baoquan Xie ◽  
Xianggui Liu ◽  
Xia Gao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cell Adhesion ◽  
Mechanical Strength ◽  
Synthetic Polymer ◽  
Natural Polymer ◽  
Tissue Engineering Scaffolds ◽  
Adhesion Properties ◽  
High Mechanical Strength ◽  
Double Network

A novel physically linked double-network (DN) hydrogel was prepared by natural polymer KGM and synthetic polymer PAAm. The DN hydrogels exhibit good mechanical properties, cell adhesion properties, and can be freely shaped, making such hydrogels promising for tissue engineering scaffolds.

Morphology of Polyamideliquid Crystalline Polymer Blend

1990 ◽  
Vol 215 ◽  
Author(s):  
K. Nishii ◽  
M. Usui ◽  
T. Muraya ◽  
K. Kimura
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Polymer Blend ◽  
Liquid Crystalline Polymer ◽  
Liquid Crystalline ◽  
Crystalline Polymer ◽  
Polymer Structure ◽  
High Mechanical Strength ◽  
Blend Morphology ◽  
The Relationship

Polymer blend technology is attractive from the standpoint of both science and industry, and many combinations have been studied. Recently, the polymer blends, including liquid crystalline polymer, have been especially worthy of notice, [1,2,3]. In order to obtain materials with a high mechanical strength and moldability for use in thin molded items, we chose polyamide (PA)-liquid crystalline polymer (LCP) blends. In this study, we first measured the mechanical properties, then studied the features of the polymer structure. We also examined the relationship between morphology and mechanical properties. As a result, we found that the mechanical properties of the blends depended largely on blend morphology, and that mechanical strength increased as blend compatibility increased. On the other hand, we also found that the blends showed compatible and microheterogeneous dispersion at less than 25 wt% LCP, while at more than 30 wt% LCP, blends tended to show twophase separation.

scholarly journals High strength and low swelling composite hydrogels from gelatin and delignified wood

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shennan Wang ◽  
Kai Li ◽  
Qi Zhou
Keyword(s):  
Mechanical Strength ◽  
High Strength ◽  
Honeycomb Structure ◽  
Composite Hydrogel ◽  
High Porosity ◽  
High Mechanical Strength ◽  
Composite Hydrogels ◽  
Freeze Dried ◽  
Strength And Stiffness ◽  
Phosphate Buffered Saline

Abstract A delignified wood template with hydrophilic characteristics and high porosity was obtained by removal of lignin. Gelatin was infiltrated into the delignified wood and further crosslinked with a natural crosslinker genipin to form hydrogels. The composite hydrogels showed high mechanical strength under compression and low swelling in physiological condition. The effect of genipin concentrations (1, 50 and 100 mM) on structure and properties of the composite hydrogels were studied. A porous honeycomb structure with tunable pore size and porosity was observed in the freeze-dried composite hydrogels. High elastic modulus of 11.82 ± 1.51 MPa and high compressive yield stress of 689.3 ± 34.9 kPa were achieved for the composite hydrogel with a water content as high as 81%. The equilibrium water uptake of the freeze-dried hydrogel in phosphate buffered saline at 37 °C was as low as 407.5%. These enables the delignified wood structure an excellent template in composite hydrogel preparation by using infiltration and in-situ synthesis, particularly when high mechanical strength and stiffness are desired.

scholarly journals Expanded graphene oxide fibers with high strength and increased elongation

RSC Advances ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 4198-4202 ◽  
Author(s):  
Ashok D. Ugale ◽  
LinLin Chi ◽  
Min-Kyu Kim ◽  
Sudong Chae ◽  
Jae-Young Choi ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Mechanical Strength ◽  
Basal Plane ◽  
High Strength ◽  
Interplanar Distance ◽  
High Mechanical Strength ◽  
Plane Interaction

The increased interplanar distance between the EGO sheets favored the edge-to-edge than basal plane interaction within the fiber, resulting in high mechanical strength (492 MPa) and increased elongation (6.1%).

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