scholarly journals Effect of pyrrolo[3,4-d]pyridazinone derivatives in neuroinflammation induced by preincubation with lipopolysaccharide or coculturing with microglia-like cells

2021 ◽  
Vol 141 ◽  
pp. 111878
Author(s):  
Katarzyna Potyrak ◽  
Benita Wiatrak ◽  
Edward Krzyżak ◽  
Łukasz Szczukowski ◽  
Piotr Świątek ◽  
...  
Keyword(s):  
Pyridazinone Derivatives

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Industrial Chemical ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

Pyridazinone derivatives: Design, synthesis, and in vitro vasorelaxant activity

2008 ◽  
Vol 16 (1) ◽  
pp. 382-389 ◽  
Author(s):  
Khaled Abouzid ◽  
Maha Abdel Hakeem ◽  
Omnya Khalil ◽  
Yosria Maklad
Keyword(s):  
Design Synthesis ◽  
Vasorelaxant Activity ◽  
Pyridazinone Derivatives

ChemInform Abstract: An Efficient Synthesis of 4,5-Dihydro-3(2H)-pyridazinone Derivatives (IV)

ChemInform ◽  
2010 ◽  
Vol 28 (52) ◽  
pp. no-no
Author(s):  
G. TOTH ◽  
S. MOLNAR ◽  
T. TAMAS ◽  
I. BORBELY
Keyword(s):  
Efficient Synthesis ◽  
Pyridazinone Derivatives

scholarly journals Studies on Pyridazone Derivatives. III. : Synthesis of 2-Phenyl-3 (2H)-pyridazinone Derivatives

1968 ◽  
Vol 88 (6) ◽  
pp. 784-787 ◽  
Author(s):  
TORIZO TAKAHASHI ◽  
YOSHIFUMI MAKI ◽  
MASAHIRO TAKAYA ◽  
HIROKO KIZU
Keyword(s):  
Pyridazinone Derivatives

Enamines in Heterocyclic Synthesis: A Novel Simple and Efficient Route to Condensed Pyridazines

2011 ◽  
Vol 66 (6) ◽  
pp. 597-602
Author(s):  
Elham S. Darwish ◽  
Mahmoud A. Abdelrahman ◽  
Abdellatif M. Salaheldin
Keyword(s):  
Hydrazine Hydrate ◽  
Triethyl Orthoformate ◽  
Heterocyclic Synthesis ◽  
Active Methyl ◽  
Efficient Route ◽  
Pyridazinone Derivatives

An efficient and easy preparation of enamine derivatives, via active methyl and methylene compounds by in situ-generated 1-(diethoxymethyl)piperidine, produced from the mixture of triethyl orthoformate/piperidine/DMF, are described. Some new pyridazinone derivatives have been synthesized from the reaction of enamines with hydrazine hydrate and cyanoacid hydrazide.

scholarly journals New Spiro[cycloalkane-pyridazinone] Derivatives with Favorable Fsp3 Character

Chemistry ◽  
2020 ◽  
Vol 2 (4) ◽  
pp. 837-848
Author(s):  
Csilla Sepsey Für ◽  
Hedvig Bölcskei
Keyword(s):  
High Throughput Screening ◽  
Pharmaceutical Companies ◽  
Compound Library ◽  
Aromatic Rings ◽  
Lead Discovery ◽  
Lipinski’S Rule ◽  
Design And Synthesis ◽  
Lipinski’S Rule Of Five ◽  
Pyridazinone Derivatives ◽  
New Compounds

The large originator pharmaceutical companies need more and more new compounds for their molecule banks, because high throughput screening (HTS) is still a widely used method to find new hits in the course of the lead discovery. In the design and synthesis of a new compound library, important points are in focus nowadays: Lipinski’s rule of five (RO5); the high Fsp3 character; the use of bioisosteric heterocycles instead of aromatic rings. With said aim in mind, we have synthesized a small compound library of new spiro[cycloalkane-pyridazinones] with 36 members. The compounds with this new scaffold may be useful in various drug discovery projects.

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