New Spiro[cycloalkane-pyridazinone] Derivatives with Favorable Fsp3 Character
Keyword(s):
The large originator pharmaceutical companies need more and more new compounds for their molecule banks, because high throughput screening (HTS) is still a widely used method to find new hits in the course of the lead discovery. In the design and synthesis of a new compound library, important points are in focus nowadays: Lipinski’s rule of five (RO5); the high Fsp3 character; the use of bioisosteric heterocycles instead of aromatic rings. With said aim in mind, we have synthesized a small compound library of new spiro[cycloalkane-pyridazinones] with 36 members. The compounds with this new scaffold may be useful in various drug discovery projects.
2016 ◽
Vol 6
(4)
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pp. 124-130
2014 ◽
Vol 19
(5)
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pp. 758-770
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2020 ◽
Vol 16
(3)
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pp. 295-307
2015 ◽
Vol 60
(1)
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pp. 640-645
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2020 ◽
Vol 11
(3)
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pp. 9871-9879
2005 ◽
Vol 10
(7)
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pp. 725-729
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