scholarly journals Untargeted metabolomics analysis of the anti-diabetic effect of Red ginseng extract in Type 2 diabetes Mellitus rats based on UHPLC-MS/MS

2022 ◽  
Vol 146 ◽  
pp. 112495
Author(s):  
Zijun Yang ◽  
Dan Wang ◽  
Yuanyuan Li ◽  
Xinfeng Zhou ◽  
Tiantian Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Untargeted Metabolomics ◽  
Red Ginseng ◽  
Ginseng Extract ◽  
Metabolomics Analysis

scholarly journals Novel Biomarkers to Distinguish between Type 3c and Type 2 Diabetes Mellitus by Untargeted Metabolomics

Metabolites ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 423
Author(s):  
Cristina Jimenez-Luna ◽  
Ariadna Martin-Blazquez ◽  
Carmelo Dieguez-Castillo ◽  
Caridad Diaz ◽  
Jose Luis Martin-Ruiz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Roc Curve ◽  
High Resolution Mass Spectrometry ◽  
Correct Diagnosis ◽  
Principal Component ◽  
Untargeted Metabolomics ◽  
Serum Samples

Pancreatogenic diabetes mellitus (T3cDM) is a highly frequent complication of pancreatic disease, especially chronic pancreatitis, and it is often misdiagnosed as type 2 diabetes mellitus (T2DM). A correct diagnosis allows the appropriate treatment of these patients, improving their quality of life, and various technologies have been employed over recent years to search for specific biomarkers of each disease. The main aim of this metabolomic project was to find differential metabolites between T3cDM and T2DM. Reverse-phase liquid chromatography coupled to high-resolution mass spectrometry was performed in serum samples from patients with T3cDM and T2DM. Multivariate Principal Component and Partial Least Squares-Discriminant analyses were employed to evaluate between-group variations. Univariate and multivariate analyses were used to identify potential candidates and the area under the receiver-operating characteristic (ROC) curve was calculated to evaluate their diagnostic value. A panel of five differential metabolites obtained an area under the ROC curve of 0.946. In this study, we demonstrate the usefulness of untargeted metabolomics for the differential diagnosis between T3cDM and T2DM and propose a panel of five metabolites that appear altered in the comparison between patients with these diseases.

Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

2011 ◽  
Vol 17 (12) ◽  
pp. 937-944 ◽  
Author(s):  
Sina Kim ◽  
Byung-Cheul Shin ◽  
Myeong Soo Lee ◽  
Hyangsook Lee ◽  
Edzard Ernst
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Randomized Controlled Trials ◽  
Controlled Trials ◽  
Red Ginseng ◽  
Randomized Controlled

Novel Biomarkers to Distinguish between Type 3c versus Type 2 Diabetes Mellitus by Untargeted Metabolomics

Pancreatology ◽  
2020 ◽  
Vol 20 ◽  
pp. S98
Author(s):  
O. Caba ◽  
C. Jiménez-Luna ◽  
A. Martín-Blázquez ◽  
C. Diéguez-Castillo ◽  
Pérez Del Palacio J. ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Untargeted Metabolomics ◽  
Novel Biomarkers
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