scholarly journals Ethanolic extract of Pyrrosia lingua (Thunb.) Farw. ameliorates OVX-induced bone loss and RANKL-induced osteoclastogenesis

2022 ◽  
Vol 147 ◽  
pp. 112640
Author(s):  
Seon-A. Jang ◽  
Youn-Hwan Hwang ◽  
Hyun Yang ◽  
Jin Ah Ryuk ◽  
Dong Ryun Gu ◽  
...  
Keyword(s):  
Bone Loss ◽  
Ethanolic Extract

scholarly journals Flemingia macrophyllaExtract Ameliorates Experimental Osteoporosis in Ovariectomized Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Hui-Ya Ho ◽  
Jin-Bin Wu ◽  
Wen-Chuan Lin
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Bone Marrow Cells ◽  
Serum Alkaline Phosphatase ◽  
Osteoclast Differentiation ◽  
Ethanolic Extract ◽  
Ovariectomized Rats ◽  
Native Plant ◽  
Experimental Osteoporosis

Flemingia macrophylla(Leguminosae), a native plant of Taiwan, is used as folk medicine. Anin vitrostudy showed that a 75% ethanolic extract ofF. macrophylla(FME) inhibited osteoclast differentiation of cultured rat bone marrow cells, and the active component, lespedezaflavanone A (LDF-A), was isolated. It was found that oral administration of FME for 13 weeks suppressed bone loss in ovariectomized rats, an experimental model of osteoporosis. In addition, FME decreased urinary deoxypyridinoline concentrations but did not inhibit serum alkaline phosphatase activities, indicating that it ameliorated bone loss via inhibition of bone resorption. These results suggest that FME may represent a useful remedy for the treatment of bone resorption diseases, such as osteoporosis. In addition, LDF-A could be used as a marker compound to control the quality of FME.

Ethanolic extract of Otostegia persica ameliorates bone loss in diabetic rats irrespective to its glucose lowering effect

2013 ◽  
Vol 23 (5) ◽  
pp. 1147-1151
Author(s):  
Maryam Rezaian ◽  
Tahoora Shomali ◽  
Aydin Dilmaghanian ◽  
Ali Rassouli
Keyword(s):  
Bone Loss ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Glucose Lowering ◽  
Lowering Effect ◽  
Otostegia Persica ◽  
Glucose Lowering Effect

scholarly journals Ethanolic Extract of Rubus coreanus Fruits Inhibits Bone Marrow-Derived Osteoclast Differentiation and Lipopolysaccharide-Induced Bone Loss

2017 ◽  
Vol 12 (12) ◽  
pp. 1934578X1701201
Author(s):  
Tae-Ho Kim ◽  
Chae Gyeong Jeong ◽  
Hyeong-U Son ◽  
Man-Il Huh ◽  
Shin-Yoon Kim ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Resorption ◽  
Bone Loss ◽  
Osteoclast Differentiation ◽  
Ethanolic Extract ◽  
Type I ◽  
Mineral Density ◽  
Induced Differentiation ◽  
Rubus Coreanus

The inhibition of osteoclast differentiation/bone resorption is a well-known therapeutic strategy for controlling pathological and postmenopausal bone loss. Natural products that specifically inhibit osteoclastogenesis could therefore be developed as antiresorptive drugs for the treatment of metabolic bone disorders characterized by excessive osteoclastic bone resorption. We therefore examined the effects of Rubus coreanus extract (eeRc) on receptor activator of nuclear factor kappa-B ligand (RANKL)-induced differentiation of bone marrow macrophages (BMMs) into osteoclasts and pit formation in vitro. Additionally, the in vivo effects of the eeRc were observed in mice with lipopolysaccharide (LPS)-induced bone erosion. In this study, we found that the ethanolic extract of Rubus coreanus fruits considerably suppressed the RANKL-induced differentiation of primary BMMs into osteoclasts and bone-resorbing activity of mature osteoclasts. Oral administration of eeRc attenuated LPS-induced bone loss in vivo, as demonstrated by the reversal of LPS-induced reduction in bone volume per tissue volume, bone mineral density, and trabecular number to some extent in eeRc-treated mice. In addition, eeRc slightly decreased the serum levels of C-terminal telopeptide fragments of type I collagen, the collagen-breakdown product generated by osteoclasts. Collectively, our results indicate that eeRc has the potential to inhibit bone loss by blocking osteoclast differentiation and could therefore be a promising natural product for the prevention and/or treatment of inflammatory bone loss.

Disease severity predicts bone loss: A longitudinal study in inflammatory bowel disease patients

2001 ◽  
Vol 120 (5) ◽  
pp. A628-A628
Author(s):  
S HENDERSON ◽  
S DHALIWAL ◽  
N HOFFMAN ◽  
R PRINCE
Keyword(s):  
Inflammatory Bowel Disease ◽  
Longitudinal Study ◽  
Bone Loss ◽  
Disease Severity ◽  
Bowel Disease ◽  
Inflammatory Bowel

Bone loss in patients with Crohn's disease: A longterm-follow up study

2001 ◽  
Vol 120 (5) ◽  
pp. A628-A628
Author(s):  
P CLEMENS ◽  
V HAWIG ◽  
M MUELLER ◽  
J SCAENZLIN ◽  
B KLUMP ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bone Loss ◽  
Follow Up Study

OC Helps Anorexic Teenagers Offset Bone Loss

2005 ◽  
Vol 39 (8) ◽  
pp. 36
Author(s):  
JANE SALODOF MACNEIL
Keyword(s):  
Bone Loss

Investigate Bone Loss in Older Women on AEDs

2005 ◽  
Vol 38 (8) ◽  
pp. 23
Author(s):  
BRUCE JANCIN
Keyword(s):  
Bone Loss ◽  
Older Women

Two Studies Link SSRIs To Substantial Bone Loss

2005 ◽  
Vol 38 (7) ◽  
pp. 36
Author(s):  
TIMOTHY F. KIRN
Keyword(s):  
Bone Loss

Low Vitamin D Tied to Bone Loss in Breast Cancer

2006 ◽  
Vol 39 (15) ◽  
pp. 29
Author(s):  
JANE SALODOF MACNEIL
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Bone Loss
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