Epstein–Barr Virus Transformed DNA as a Source of False Positive Findings in Methylation Studies of Psychiatric Conditions

2011 ◽  
Vol 70 (5) ◽  
pp. e25-e26 ◽  
Author(s):  
Karolina Åberg ◽  
Edwin J.C.G. van den Oord
Keyword(s):  
False Positive ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Psychiatric Conditions ◽  
Epstein Barr

Reply to: Epstein-Barr Virus Transformed DNA as a Source of False Positive Findings in Methylation Studies of Psychiatric Conditions

2011 ◽  
Vol 70 (5) ◽  
pp. e27-e28 ◽  
Author(s):  
Robert Philibert ◽  
Kristin Caspers ◽  
Steven R.H. Beach ◽  
Marian J. Bakermans-Kranenburg ◽  
Marinus H. van IJzendoorn
Keyword(s):  
False Positive ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Psychiatric Conditions ◽  
Epstein Barr

Epstein-barr virus and cytomegalovirus infections cause false-positive results in IgM two-test protocol for early lyme borreliosis

Infection ◽  
1999 ◽  
Vol 27 (3) ◽  
pp. 231-231 ◽  
Author(s):  
H. A. T. Goossens ◽  
A. E. J. M. van den Bogaard ◽  
M. K. E. Nohlmans ◽  
A. E. J. M. van den Bogaard
Keyword(s):  
Lyme Borreliosis ◽  
False Positive ◽  
Epstein Barr Virus ◽  
Test Protocol ◽  
Barr Virus ◽  
Epstein Barr ◽  
Cytomegalovirus Infections ◽  
Positive Results

False Positive EBNA IgM and IgG Antibody Tests for Infectious Mononucleosis in Children

PEDIATRICS ◽  
1994 ◽  
Vol 94 (6) ◽  
pp. 892-894 ◽  
Author(s):  
Dorothy Levine ◽  
Rosemary Klenk ◽  
Alan Morelli ◽  
Nancy Hofreuter ◽  
Richard C. Tilton ◽  
...  
Keyword(s):  
Virus Infection ◽  
Infectious Mononucleosis ◽  
False Positive ◽  
Epstein Barr Virus ◽  
Enzyme Linked Immunosorbent Assay ◽  
Epstein Barr Virus Infection ◽  
Igg Antibody ◽  
Barr Virus ◽  
Epstein Barr ◽  
Barr Virus Infection

Objectives. To assess the reliability of the Monolert test, a new enzyme-linked immunosorbent assay for the diagnosis of acute infectious mononucleosis (IM). Design. A retrospective laboratory and clinical analysis of 38 children diagnosed with acute IM. Setting. A suburban pediatric practice in Connecticut. Patients. Thirty-eight children (ages 18 months to 17 years) who were diagnosed with acute IM using the Monolert test during the period October 1992 to August 1993. Results. Eighty-three percent of these children had no evidence of Epstein-Barr virus infection on subsequent investigation. The false positive results of the Monolert test could not be explained on the basis of elevated antibody titers to either cytomegalovirus or Borrelia burgdorferi. Conclusion. Monolert is a poor screening test and is of little apparent value as a diagnostic test for acute Epstein-Barr virus infection in pediatric patients.

Acute hepatitis E infection associated with a false-positive serology against Epstein–Barr virus

2009 ◽  
Vol 21 (12) ◽  
pp. 1433-1435 ◽  
Author(s):  
Mariana Ghinoiu ◽  
Sylvie Naveau ◽  
Nadège Barri-Ova ◽  
Juliette Thaury ◽  
Liliane Grangeot-Keros ◽  
...  
Keyword(s):  
Acute Hepatitis ◽  
False Positive ◽  
Epstein Barr Virus ◽  
Hepatitis E ◽  
Positive Serology ◽  
Barr Virus ◽  
Acute Hepatitis E ◽  
Epstein Barr

A Quantitative Ultrastructural Study of Peripheral Blood Lymphocytes Containing Parallel Tubular Arrays in Epstein-Barr Virus and Cytomegalo-Virus Mononucleosis

1981 ◽  
Vol 39 ◽  
pp. 454-455
Author(s):  
C. M. Payne ◽  
P. M. Tennican
Keyword(s):  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Epstein Barr Virus ◽  
Absolute Lymphocyte Count ◽  
Peripheral Blood Lymphocytes ◽  
Clinical State ◽  
Barr Virus ◽  
The Absolute ◽  
Epstein Barr ◽  
Tubular Arrays

In the normal peripheral circulation there exists a sub-population of lymphocytes which is ultrastructurally distinct. This lymphocyte is identified under the electron microscope by the presence of cytoplasmic microtubular-like inclusions called parallel tubular arrays (PTA) (Figure 1), and contains Fc-receptors for cytophilic antibody. In this study, lymphocytes containing PTA (PTA-lymphocytes) were quantitated from serial peripheral blood specimens obtained from two patients with Epstein -Barr Virus mononucleosis and two patients with cytomegalovirus mononucleosis. This data was then correlated with the clinical state of the patient.It was determined that both the percentage and absolute number of PTA- lymphocytes was highest during the acute phase of the illness. In follow-up specimens, three of the four patients' absolute lymphocyte count fell to within normal limits before the absolute PTA-lymphocyte count.In one patient who was followed for almost a year, the absolute PTA- lymphocyte count was consistently elevated (Figure 2). The estimation of absolute PTA-lymphocyte counts was determined to be valid after a morphometric analysis of the cellular areas occupied by PTA during the acute and convalescent phases of the disease revealed no statistical differences.

Studies of Epstein-Barr Virus Antigens Using Immunoperoxidase and Immunofluorescence Techniques

1975 ◽  
Vol 33 ◽  
pp. 342-343
Author(s):  
R. Stephens ◽  
K. Traul ◽  
D. Woolf ◽  
P. Gaudreau
Keyword(s):  
Electron Microscopy ◽  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
If Technique ◽  
Infected Cells ◽  
Virus Antigens ◽  
Epstein Barr ◽  
Virus Capsid Antigen ◽  
Antigen Reactivity

A number of antigens have been found associated with persistent EBV infections of lymphoblastoid cells. Identification and localization of these antigens were principally by immunofluorescence (IF) techniques using sera from patients with nasopharyngeal carcinoma (NPC), Burkitt lymphoma (BL), and infectious mononucleosis (IM). Our study was mainly with three of the EBV related antigens, a) virus capsid antigen (VCA), b) membrane antigen (MA), and c) early antigens (EA) using immunoperoxidase (IP) techniques with electron microscopy (EM) to elucidate the sites of reactivity with EBV and EBV infected cells.Prior to labeling with horseradish peroxidase (HRP), sera from NPC, IM, and BL cases were characterized for various reactivities by the indirect IF technique. Modifications of the direct IP procedure described by Shabo and the indirect IP procedure of Leduc were made to enhance penetration of the cells and preservation of antigen reactivity.

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