In depth natural product discovery - Myxobacterial strains that provided multiple secondary metabolites

2020 ◽  
Vol 39 ◽  
pp. 107480 ◽  
Author(s):  
Chantal D. Bader ◽  
Fabian Panter ◽  
Rolf Müller
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Natural Product Discovery

scholarly journals Occurrence and Properties of Thiosilvatins

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 664 ◽  
Author(s):  
Maria Michela Salvatore ◽  
Rosario Nicoletti ◽  
Marina DellaGreca ◽  
Anna Andolfi
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Large Class ◽  
Low Frequency ◽  
Structural Models ◽  
Natural Product Discovery

The spread of studies on biodiversity in different environmental contexts is particularly fruitful for natural product discovery, with the finding of novel secondary metabolites and structural models, which are sometimes specific to certain organisms. Within the large class of the epipolythiodioxopiperazines, which are typical of fungi, thiosilvatins represent a homogeneous family that, so far, has been reported in low frequency in both marine and terrestrial contexts. However, recent observations indicate that these compounds have been possibly neglected in the metabolomic characterization of fungi, particularly from marine sources. Aspects concerning occurrence, bioactivities, structural, and biosynthetic properties of thiosilvatins are reviewed in this paper.

scholarly journals RARE ACTINOMYCETES FROM KUANTAN MANGROVE FOREST SEDIMENT

2020 ◽  
Vol 4 (2) ◽  
pp. 79-83
Author(s):  
Zaima Azira Zainal Abidin ◽  
Nurfathiah Abdul Malek ◽  
Nur Huda Mohd Zin ◽  
Ahmed Jalal Khan Chowdhury
Keyword(s):  
Secondary Metabolites ◽  
Natural Product ◽  
Mangrove Forest ◽  
Ecological Niche ◽  
Antimicrobial Properties ◽  
Mangrove Forests ◽  
Natural Product Discovery ◽  
Rare Actinomycetes ◽  
Nocardia Sp ◽  
Rhodococcus Sp

Actinomycetes are prolific secondary metabolites producer, and they are sought after for their unparalleled capability. Mangrove forests are among the underexplored locations in search of new resources of actinomycetes. Bioprospecting of actinomycetes in Kuantan mangrove forests has revealed highly diverse actinomycetes with high antimicrobial properties. Members of the rare genera successfully isolated include Micromonospora sp., Pseudonocardia sp., Verrucosispora sp., Nocardiopsis sp., Actinophytocola sp., Dietzia sp., Gordonia sp., Micrococcus sp., Mycobacterium sp., Nocardia sp., Saccharopolyspora sp. And Rhodococcus sp. These rare actinomycetes can also be added to the list of genera isolated from this ecological niche, providing solid evidence that considerable diversity of actinomycetes are distributed within Kuantan mangrove forest. PKS-I and NRPS genes are usually related to the ability to produce secondary metabolites in actinomycetes. Interestingly, several of these rare actinomycetes showed the presence of both PKS-I and NRPS genes or either gene, and this exemplifies the potential of these rare actinomycetes may possess. Further studies conducted on these rare actinomycetes may reveal their true potentials that can be exploited for natural product discovery.

scholarly journals Biosynthetic Potential of Streptomyces Rationalizes Genome-Based Bioprospecting

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 873
Author(s):  
Balasubramanian Cibichakravarthy ◽  
Polapass Arul Jose
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Natural Product ◽  
Natural Product Discovery ◽  
New Compounds ◽  
Microbial Natural Products

Streptomyces are the most prolific source of structurally diverse microbial natural products. Advancing genome-based analysis reveals the previously unseen potential of Streptomyces to produce numerous novel secondary metabolites, which allows us to take natural product discovery to the next phase. However, at present there is a huge disproportion between the rate of genome reports and discovery of new compounds. From this perspective of harnessing the enduring importance of Streptomyces, we discuss the recent genome-directed advancements inspired by hidden biosynthetic wealth that provide hope for future antibiotics.

scholarly journals Chemical Elicitors Induce Rare Bioactive Secondary Metabolites in Deep-Sea Bacteria under Laboratory Conditions

Metabolites ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 107
Author(s):  
Rafael de Felício ◽  
Patricia Ballone ◽  
Cristina Freitas Bazzano ◽  
Luiz F. G. Alves ◽  
Renata Sigrist ◽  
...  
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Natural Product ◽  
Deep Sea ◽  
Chemical Space ◽  
Bacterial Genome ◽  
Vast Number ◽  
Bacterial Metabolites ◽  
Laboratory Conditions ◽  
Deep Sea Bacteria

Bacterial genome sequencing has revealed a vast number of novel biosynthetic gene clusters (BGC) with potential to produce bioactive natural products. However, the biosynthesis of secondary metabolites by bacteria is often silenced under laboratory conditions, limiting the controlled expression of natural products. Here we describe an integrated methodology for the construction and screening of an elicited and pre-fractionated library of marine bacteria. In this pilot study, chemical elicitors were evaluated to mimic the natural environment and to induce the expression of cryptic BGCs in deep-sea bacteria. By integrating high-resolution untargeted metabolomics with cheminformatics analyses, it was possible to visualize, mine, identify and map the chemical and biological space of the elicited bacterial metabolites. The results show that elicited bacterial metabolites correspond to ~45% of the compounds produced under laboratory conditions. In addition, the elicited chemical space is novel (~70% of the elicited compounds) or concentrated in the chemical space of drugs. Fractionation of the crude extracts further evidenced minor compounds (~90% of the collection) and the detection of biological activity. This pilot work pinpoints strategies for constructing and evaluating chemically diverse bacterial natural product libraries towards the identification of novel bacterial metabolites in natural product-based drug discovery pipelines.

scholarly journals Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches

2021 ◽  
Author(s):  
Mehdi A. Beniddir ◽  
Kyo Bin Kang ◽  
Grégory Genta-Jouve ◽  
Florian Huber ◽  
Simon Rogers ◽  
...  
Keyword(s):  
Natural Product ◽  
Large Scale ◽  
Scale Analysis ◽  
Computational Tools ◽  
Natural Product Discovery ◽  
Large Scale Analysis ◽  
Metabolite Annotation

This review highlights the key computational tools and emerging strategies for metabolite annotation, and discusses how these advances will enable integrated large-scale analysis to accelerate natural product discovery.

scholarly journals MeFSAT: a curated natural product database specific to secondary metabolites of medicinal fungi

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2596-2607
Author(s):  
R. P. Vivek-Ananth ◽  
Ajaya Kumar Sahoo ◽  
Kavyaa Kumaravel ◽  
Karthikeyan Mohanraj ◽  
Areejit Samal
Keyword(s):  
Natural Products ◽  
Secondary Metabolites ◽  
Natural Product ◽  
Chemical Space ◽  
Therapeutic Uses ◽  
Medicinal Fungi ◽  
Fungal Natural Products

First dedicated manually curated resource on secondary metabolites and therapeutic uses of medicinal fungi. Cheminformatics based analysis of the chemical space of fungal natural products.

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