A Clinical Audit on the Management of Oral Lichen Planus within the Oral and Maxillo-facial Department at the University Hospital of Manchester

AbstractBackground:Background: Of the acquired ear canal atresias, idiopathic, inflammatory, medial meatal, fibrotising otitis has been suggested as a distinct disease entity, for reasons of aetiology.Objective:To report three more cases of idiopathic, inflammatory, medial meatal, fibrotising otitis and to further consider the possible relationship between this condition and lichen planus.Patients:Three adult patients with idiopathic, inflammatory, medial meatal, fibrotising otitis, two with bilateral aural symptoms, treated and followed up at the department of otorhinolaryngology of Helsinki University Hospital.Results:We found idiopathic, inflammatory, medial meatal, fibrotising otitis, affecting solely the glabrous skin of the osseous part of the external ear canals, in three patients who also suffered from severe oral lichen planus.Conclusions:The aetiopathology or pathophysiology of idiopathic, inflammatory, medial meatal, fibrotising otitis may be linked with lichen planus. Early, active treatment of idiopathic, inflammatory, medial meatal, fibrotising otitis with local corticosteroids may prevent total medial meatal atresia.

Download Full-text

Topical Calcineurin Inhibitor Tacrolimus in Orabase: an Alternative Treatment for Erosive Oral Lichen Planus

Revista de Chimie ◽

10.37358/rc.20.4.8085 ◽

2020 ◽

Vol 71 (4) ◽

pp. 438-445

Author(s):

Mihaela Paula Toader ◽

Madalina Mocanu ◽

Stefan Toader ◽

Roxana Irina Iancu ◽

Tatiana Taranu

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Large Scale ◽

Lymphocyte Activation ◽

Topical Tacrolimus ◽

Beneficial Effects ◽

Dermatology Clinic ◽

Cellular Immune ◽

The University ◽

Oral Lichen

Tacrolimus, a macrolide with immunosuppressive properties through the inhibition of T-lymphocyte activation, was approved as a second line topical treatment for atopic dermatitis, but has been largely used with beneficial effects in other dermatological conditions that involve a disregulation of the cellular immune response. Oral lichen planus is a T-cell�mediated autoimmune disease in which autocytotoxic CD8+ T cells trigger apoptosis of oral epithelial cells. Our study aimed to analyze the clinical efficacy of tacrolimus 0.03% and 0.1% in orabase as monotherapy on oral erosive lesions of lichen planus, in a group of 20 patients consulted in the Dermatology Clinic of the University C.F. Hospital Iasi during a period of five years. Our results show total or partial remission of oral erosive lesions in most patients at 3 months follow-up. However, after treatment discontinuation relapses are common, which is why intermittent use of topical tacrolimus is needed for longer periods to prevent recurrences. Further large scale studies are necessary to establish efficacy and safety profile of prolonged use of tacrolimus on mucosal membranes, as well as the most appropriate vehicle and concentration.

Download Full-text

Gyvenimo kokybė sergant erozineopine ir retikuline plokščiosios kerpligės formomis

Sveikatos mokslai ◽

10.5200/sm-hs.2013.018 ◽

2013 ◽

Vol 23 (1) ◽

pp. 100-102

Author(s):

Arūnas Rimkevičius ◽

Jolanta Aleksejūnienė ◽

Alina Pūrienė ◽

Mindaugas Gaigalas

Keyword(s):

Lichen Planus ◽

Oral Lichen Planus ◽

Life Quality ◽

University Hospital ◽

Quality Aspects ◽

Vilnius University ◽

Physical Comfort ◽

Oral Lichen ◽

Reticular Form

The present work analyses various life quality aspects of 79 patients with oral lichen planus, who were examined in the Žalgiris Clinic of Vilnius University Hospital in the period 2009-2012. Oral lichen planus had different forms of the disease and individual experience, which impacted quality of life. The erosive-ulcerative form of the disease as compared to reticular form had more detrimental influence on psychological, social or physical comfort of patients. A high percentage of patients (48,3% erosive-ulcerative form and 44,5% reticular form) were concerned about their future with oral lichen planus.

Download Full-text

The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation—A Retrospective Study of 271 Patients

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18126525 ◽

2021 ◽

Vol 18 (12) ◽

pp. 6525

Author(s):

Vladimíra Radochová ◽

Romana Koberová Ivančaková ◽

Ondřej Heneberk ◽

Radovan Slezák

Keyword(s):

Retrospective Study ◽

Malignant Transformation ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Chronic Inflammatory Disease ◽

University Hospital ◽

Unknown Etiology ◽

Transformation Rate ◽

Oral Lichen

Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with an unknown etiology rating among oral potentially malignant disorder. The aim of the study was to determine the epidemiological and clinical characteristics of the patients with OLP and rate of malignant transformation. Patients and methods: Data were obtained from the medical records of 271 patients referred to the Oral Medicine Unit at the University Hospital in Hradec Králové diagnosed with oral lichen planus in the period of 2003–2020. The records were retrospectively analyzed. The following clinical data were retrieved from the medical charts: gender, age, systemic diseases, alcohol and tobacco consumption, localization/clinical appearance of lesions, distribution of the lesions, presence of the symptoms, treatment provided and malignant transformation. Results: A total of 271 charts of patients with confirmed diagnosis of OLP were retrospectively analyzed, of whom, 66.4% (180/271) were women and 33.6% (91/271) were men. The mean age of the patients was 56.0 (18.2–85.0) years. The median follow-up of all patients was 15.2 months. Overall, 2 patients (2/271, 0.74%) meeting the above-mentioned criteria for malignant transformation were identified during the follow-up period. Both patients suffered from erosive type OLP and developed squamous cell carcinoma of the tongue. Conclusions: This retrospective study is in concordance with other studies showing the similar profile and clinical features of the patients with OLP. Malignant transformation rate was 0.74%.

Download Full-text

Cost of illness of oral lichen planus: a multicenter university hospital–based outpatient observational study

Clinical Oral Investigations ◽

10.1007/s00784-021-04353-1 ◽

2022 ◽

Author(s):

Lajolo C ◽

Rupe C ◽

Gioco G ◽

Giuliani M ◽

Contaldo M ◽

...

Keyword(s):

Immunosuppressive Therapy ◽

Lichen Planus ◽

Cost Of Illness ◽

Annual Cost ◽

Oral Lichen Planus ◽

Therapy Group ◽

University Hospital ◽

The Mean ◽

Oral Lichen ◽

Italian Cohort

Abstract Objectives To estimate the economic costs of oral lichen planus (OLP) through a multicenter university hospital–based outpatient study conducted in Italy and Finland. Materials and methods A multicenter retrospective study was conducted on patients affected by OLP to evaluate the economic cost of managing the disease. Direct costs concerning diagnostic procedures, therapeutic management, and follow-up visits were obtained from clinical records. Statistics was performed with IBM SPSS Statistics. Results One hundred and eight patients with a confirmed diagnosis of OLP (81 women and 27 men), 58 Italians and 50 Finnish, were enrolled in this study. The mean annual cost was 1087.2 euros per patient. The mean annual cost was higher in Finnish than in Italian cohort (1558.7 euros vs. 680.7 euros—p < 0.05). Within the Italian cohort, the local immunosuppressive therapy group and atrophic and erosive OLP type had a higher cost (p < 0.05). Within the Finnish cohort, the local immunosuppressive therapy group had a higher cost (p < 0.05). Conclusions OLP-related costs are very similar to other chronic oral disorders (i.e., periodontitis) with differences between investigated countries. Moreover, patients with more severe clinical features, who need immunosuppressive therapy, are facing more expensive costs. Clinical relevance. In this multicenter cost of illness study, we estimated the direct health care costs of OLP and we found that patients with more severe clinical features, who therefore need symptomatic therapy, are facing more expensive costs.

Download Full-text