scholarly journals The Characteristics of Patients with Oral Lichen Planus and Malignant Transformation—A Retrospective Study of 271 Patients

2021 ◽  
Vol 18 (12) ◽  
pp. 6525
Author(s):  
Vladimíra Radochová ◽  
Romana Koberová Ivančaková ◽  
Ondřej Heneberk ◽  
Radovan Slezák
Keyword(s):  
Retrospective Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
University Hospital ◽  
Unknown Etiology ◽  
Transformation Rate ◽  
Oral Lichen

Introduction: Oral lichen planus (OLP) is a chronic inflammatory disease with an unknown etiology rating among oral potentially malignant disorder. The aim of the study was to determine the epidemiological and clinical characteristics of the patients with OLP and rate of malignant transformation. Patients and methods: Data were obtained from the medical records of 271 patients referred to the Oral Medicine Unit at the University Hospital in Hradec Králové diagnosed with oral lichen planus in the period of 2003–2020. The records were retrospectively analyzed. The following clinical data were retrieved from the medical charts: gender, age, systemic diseases, alcohol and tobacco consumption, localization/clinical appearance of lesions, distribution of the lesions, presence of the symptoms, treatment provided and malignant transformation. Results: A total of 271 charts of patients with confirmed diagnosis of OLP were retrospectively analyzed, of whom, 66.4% (180/271) were women and 33.6% (91/271) were men. The mean age of the patients was 56.0 (18.2–85.0) years. The median follow-up of all patients was 15.2 months. Overall, 2 patients (2/271, 0.74%) meeting the above-mentioned criteria for malignant transformation were identified during the follow-up period. Both patients suffered from erosive type OLP and developed squamous cell carcinoma of the tongue. Conclusions: This retrospective study is in concordance with other studies showing the similar profile and clinical features of the patients with OLP. Malignant transformation rate was 0.74%.

scholarly journals Markers of Oral Lichen Planus Malignant Transformation

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Mircea Tampa ◽  
Constantin Caruntu ◽  
Madalina Mitran ◽  
Cristina Mitran ◽  
Isabela Sarbu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Squamous Cell Carcinoma ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
Unknown Etiology ◽  
Molecular Alterations ◽  
Oral Lichen

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients’ quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression. In this review, we discuss various studies which highlight different molecules as ominous predictors of OLP malignant transformation.

Clinicopathological features and malignant transformation of oral lichen planus: A 12-years retrospective study

2012 ◽  
Vol 71 (3-4) ◽  
pp. 834-840 ◽  
Author(s):  
Elena Bardellini ◽  
Francesca Amadori ◽  
Pierangela Flocchini ◽  
Sara Bonadeo ◽  
Alessandra Majorana
Keyword(s):  
Retrospective Study ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinicopathological Features ◽  
Oral Lichen

scholarly journals GRINSPAN SYNDROME: THE TRIAD

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Seema M ◽  
Shruti Srinivasan
Keyword(s):  
Diabetes Mellitus ◽  
Early Detection ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Clinical Manifestations ◽  
Prevention And Early Detection ◽  
Burning Mouth ◽  
Oral Lichen

Lichen Planus is a chronic immunologically mediated mucocutaneous disorder with varied clinical manifestations. The condition might be associated with multiple causative or exacerbation factors. An interesting association of Oral Lichen Planus with Diabetes Mellitus and vascular hypertension is called as Grinspan's syndrome. Since its inception has been an arena of interest. It has appeared very lucrative to many researchers as it lacks clarity and enhanced ambiguity. A 65 year female patient came with a complaint of burning mouth and difficulty in swallowing since 1 year with H/O Diabetes Mellitus since 8years and hypertension since 2 years. Malignant transformation is the most significant complication of long standing and non healing Lichen Planus. Repeated follow up and biopsies are mandatory for prevention and early detection of malignant transformation. Keywords: Grinspan Syndrome, Hypertrophic Lichen Planus, Esophageal Lichen Planus

scholarly journals Photobiomodulation Therapy vs. Corticosteroid for the Management of Erosive/Ulcerative and Painful Oral Lichen Planus. Assessment of Success Rate during One-Year Follow-Up: A Retrospective Study

Healthcare ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1137
Author(s):  
Samir Nammour ◽  
Marwan El Mobadder ◽  
Aldo Brugnera ◽  
Melanie Namour ◽  
Saad Houeis ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Recurrence Rate ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Continuous Wave ◽  
Clinical Aspects ◽  
Complete Disappearance ◽  
Significant Difference ◽  
Oral Lichen

Photobiomodulation (PBM) therapy is a promising approach for the management of inflammatory conditions and autoimmune lesions, such as oral lichen planus (OLP). The aim of this retrospective study was to assess the effectiveness of PBM in the management of painful and erosive/ulcerative OLP and to compare it with the standard of care that is the topical application of corticosteroids. 96 patients were included with erosive and painful OLP. 48 patients received PBM therapy and 48 received corticosteroids. Data was collected retrospectively on pain using the visual analogue scale; clinical aspects of lesions were assessed with the REU score, and the recurrence rate was noted. One session of PBM therapy with a helium-neon red light (635 nm) was carried out every 48 h for 6 weeks. Treatments were mainly made in contact mode, using a fiber with a diameter of 600 µm (0.6 mm). The output power of the laser beam was calibrated by a power meter. A delivered power of 0.1 W was used for 40 s in a continuous wave (CW), corresponding to a delivered energy of 4 J. The delivered energy density related to the fiber diameter was 1415 J/cm2. Each treated point was considered as 1 cm2 of diameter. PBM therapy within these parameters was carried out on each point until the totality of the lesion was covered, including the non-erosive OLP area. Furthermore, healthy mucosa within 5 mm of the lesion was also irradiated with the same conditions. This PBM treatment was performed during 6 consecutive weeks. The topical corticosteroid treatment consisted of cortisone application to cover the OLP 3 times/day for 6 weeks. Follow-up was made at 6 weeks and at 3, 6 and 12 months. After 6 weeks, both groups showed complete absence of pain, and a complete disappearance of ulcerative/erosive areas. No significant difference was found for both groups concerning the recurrence rate of erosive OLP during the follow-up period; values were 0% at 6 weeks for both groups and 79% and 87.5% for the corticosteroid and PBM group, respectively, at 12 months of follow-up. PBM is effective for managing OLP and is significantly similar to topical corticosteroids without any need for the use of medication and with no reported side effects.

scholarly journals Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Fumihiko Tsushima ◽  
Jinkyo Sakurai ◽  
Atsushi Uesugi ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Japanese Patients ◽  
Histopathological Diagnosis ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Oral Lichenoid Lesions ◽  
Potentially Malignant ◽  
Oral Lichen

Abstract Background Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease that is recognized as an oral potentially malignant disorder. However, the potentially malignant nature of OLP remains unclear. Methods We designed this study to examine the demographic and clinical characteristics of patients with OLP and evaluate the associated malignant transformation rate. A total of 565 patients with a clinical and histopathological diagnosis of OLP who presented at our department between 2001 and 2017 were retrospectively studied. Patients who had clinical and histopathological features of oral lichenoid lesions (OLLs) classified as oral lichenoid contact lesions, oral lichenoid drug reactions and oral lichenoid lesions of graft-versus-host disease were excluded. Results The study population included 123 men and 442 women aged 21–93 years (mean ± standard deviation, 60.5 ± 11.8). The 565 patients were followed up for a duration of 55.9 ± 45.3 months, during which 4 (0.7%) patients developed squamous cell carcinoma (SCC). In three of these 4 patients who developed SCC, the clinical type of OLP was the red type. Conclusions Our results suggested that OLP was associated with a low risk of malignant transformation. We recommend regular follow-up for OLP patients and clear differentiation of oral epithelial dysplasia and OLLs to enable early detection of malignant transformation. Further investigation of the clinical risk factors associated with malignant transformation is necessary.

scholarly journals Risk co-factors inducing malignant transformation of oral lichen planus: A literature review of clinical studies

2021 ◽  
Vol 5 (1) ◽  
pp. 005-011
Author(s):  
Saleh Wafaa ◽  
Youssef Jilan M ◽  
Ata Fatma ◽  
Anees Mohamed M ◽  
Cha Seunghee ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hepatitis C ◽  
Malignant Transformation ◽  
Lichen Planus ◽  
Potential Risk ◽  
Clinical Studies ◽  
Animal Studies ◽  
Oral Lichen Planus ◽  
Chronic Inflammatory Disease ◽  
Oral Lichen

Oral lichen planus (OLP) is an autoimmune chronic inflammatory disease. The potential risk of malignant transformation in OLP remains controversial. The aim of the present study was to review original clinical studies published in indexed databases, which assessed the potential risk cofactors which were implicated in the malignant transformation of oral lichen planus. We focused our search to include most of the studies that reported malignant transformation of oral lichen planus using different combinations of the following key indexing terms: oral lichen planus, malignant transformation, smoking, alcohol, chronic inflammation, candida, human papillomavirus (HPV), hepatitis C virus (HCV) and immunosuppression. The animal studies were excluded from our study. Despite a dearth of studies on this topic we have identified consumption of tobacco and/or alcohol, the presence of erosive and/or atrophic areas, infection with candida, HCV, HPV, and immunosuppression as significant cofactors. Patients with OLP with these risk co-factors are at risk of malignant transformation should, therefore be followed up for an extensive period or even for life.

scholarly journals Systematic Review and Meta-Analysis of Oxidative Stress and Antioxidant Markers in Oral Lichen Planus

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Jia Wang ◽  
Jingjing Yang ◽  
Chen Wang ◽  
Zhibai Zhao ◽  
Yuan Fan
Keyword(s):  
Oxidative Stress ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Meta Analysis ◽  
Chronic Inflammatory Disease ◽  
Cochrane Library ◽  
Unknown Etiology ◽  
Antioxidant Systems ◽  
Antioxidant Markers ◽  
Oral Lichen

Background. Oral lichen planus (OLP) is a relatively common chronic inflammatory disease of unknown etiology, which might be caused by oxidative stress and impaired antioxidant defense. Objective. To systematically investigate the markers of oxidative stress and antioxidant systems in the saliva and blood from OLP patients and healthy controls. Methods. The PubMed, Cochrane Library, and Embase were systematically queried to collect data from studies in which oxidative stress/antioxidant markers from OLP and healthy subjects had been evaluated until March 10, 2021. Results. A total of 28 studies fulfilled inclusion criteria, and 25 of them, having 849 OLP patients and 1,052 control subjects and analyzing 12 oxidative stress and antioxidant state marker levels, were subjected to meta-analysis. We found a significant decrease in total antioxidant capacity (TAC) and uric acid (UA) and a significant increase in malondialdehyde (MDA) and nitric oxide (NO) levels in the saliva and serum/plasma of OLP patients. Moreover, a significant elevation of 8-hydroxy-deoxyguanosine (8-OHdG) and advanced oxidation protein product (AOOP) level and a decrease in vitamin C were also observed in the saliva of the OLP group. In contrast, salivary vitamin A, zinc, glutathione peroxidase (GPx), vitamin E, and nitrite were not significantly different between the two groups. In single studies, markers of oxidative stresses such as superoxide dismutase (SOD) and 8-isoprostanelevels were elevated in OLP, and antioxidant parameters such as glutathione (GSH) and total protein (TP) levels were dysregulated. Conclusion. This meta-analysis helps to clarify the profile of oxidative stress and antioxidant state markers in OLP patients although existing evidence is rather heterogeneous and many studies are affected by several limitations. Larger and more standardized studies are warranted to ascertain whether these markers are potential causes or effects of OLP and whether antioxidant therapy improving oxidative stress will be useful.

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