Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

A series of novel 4-amino-5-mercapto-3-[(3-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazoles (5a-d) were obtained by treating m-(aralkyl amido/imidoalkyl) benzoic acid hydrazides (3a-d) with carbon disulphide in alcoholic KOH and hydrazine hydrate, respectively. These triazole derivatives were employed in the synthesis of 5-[(3′-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines (6a-d). The newly synthesized compounds were evaluated for their antiviral activity against two animal viruses, namely, Japanese encephalitis virus (JEV) strain P20778 and herpes simplex virus-1 (HSV-1) strain 753166.

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Design, Synthesis, and Biological Evaluation of N-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection

Journal of Medicinal Chemistry ◽

10.1021/jm300171v ◽

2012 ◽

Vol 55 (13) ◽

pp. 6061-6075 ◽

Cited By ~ 38

Author(s):

Wenquan Yu ◽

Tina Gill ◽

Lijuan Wang ◽

Yanming Du ◽

Hong Ye ◽

...

Keyword(s):

Virus Infection ◽

Dengue Virus ◽

Biological Evaluation ◽

Dengue Virus Infection ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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C-5’-Triazolyl-2’-oxa-3’-aza-4’a-carbanucleosides: Synthesis and biological evaluation

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.11.38 ◽

2015 ◽

Vol 11 ◽

pp. 328-334 ◽

Cited By ~ 17

Author(s):

Roberto Romeo ◽

Caterina Carnovale ◽

Salvatore V Giofrè ◽

Maria A Chiacchio ◽

Adriana Garozzo ◽

...

Keyword(s):

Cell Proliferation ◽

Antitumor Activity ◽

Antiviral Activity ◽

Click Chemistry ◽

Biological Evaluation ◽

Biological Tests ◽

Synthesis And Biological Evaluation ◽

Inhibit Cell Proliferation

A novel series of 2’-oxa-3’-aza-4’a-carbanucleosides, featured with a triazole linker at the 5’-position, has been developed by exploiting a click chemistry reaction of 5’-azido-2’-oxa-3’-aza-4’a-carbanucleosides with substituted alkynes. Biological tests indicate an antitumor activity for the synthesized compounds: most of them inhibit cell proliferation of Vero, BS-C-1, HEp-2, MDCK, and HFF cells with a CC50 in the range of 5.0–40 μM. The synthesized compounds do not show any antiviral activity.

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Synthesis and biological evaluation of novel urea and thiourea derivatives of valacyclovir

Journal of the Serbian Chemical Society ◽

10.2298/jsc120716095k ◽

2014 ◽

Vol 79 (3) ◽

pp. 283-289 ◽

Cited By ~ 5

Author(s):

Ramana Katla ◽

Rasheed Syed ◽

Madhava Golla ◽

Adam Shaik ◽

Raju Chamarthi

Keyword(s):

Antioxidant Activity ◽

Antiviral Activity ◽

Elemental Analysis ◽

Antioxidant Activities ◽

Biological Evaluation ◽

Thiourea Derivatives ◽

Mass Spectral ◽

High Yields ◽

Synthesis And Biological Evaluation ◽

Derivatives Of

A series of novel urea and thiourea derivatives of valacyclovir were efficiently synthesized in high yields and evaluated their antiviral activity. 2-((6-Amino-4-oxo-4,5-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)methoxy)ethyl-2-amino-3-ethylbutanoate (valacyclovir) 1 is reacted with various aromatic isocyanates/thiocyanates 2 in the presence of N, N- dimethyl piperazine as a base in THF: pyridine (4:1) to obtain valacyclovir urea/thiourea derivatives 3(a-j). The structures of the title compounds 3(a-j) were confirmed by IR, NMR (1H, 13C), mass spectral and elemental analysis. The newly synthesized compounds were screened for their antiviral activity against Tobacco mosaic virus (TMV) and antioxidant activity was evaluated by DPPH, SOD and GST methods. The title compounds exhibited potent antiviral and good antioxidant activities.

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Synthesis and biological evaluation of novel imidazole nucleosides as potential anti-dengue virus agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2019.04.015 ◽

2019 ◽

Vol 27 (11) ◽

pp. 2181-2186 ◽

Cited By ~ 4

Author(s):

Yuki Okano ◽

Noriko Saito-Tarashima ◽

Madoka Kurosawa ◽

Ai Iwabu ◽

Masashi Ota ◽

...

Keyword(s):

Dengue Virus ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

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Synthesis and chemical characterization of several perfluorinated sialic acid glycals and evaluation of their in vitro antiviral activity against Newcastle disease virus

MedChemComm ◽

10.1039/c7md00072c ◽

2017 ◽

Vol 8 (7) ◽

pp. 1505-1513 ◽

Cited By ~ 6

Author(s):

P. Rota ◽

N. Papini ◽

P. La Rocca ◽

M. Montefiori ◽

F. Cirillo ◽

...

Keyword(s):

Sialic Acid ◽

Antiviral Activity ◽

Newcastle Disease Virus ◽

Disease Virus ◽

Newcastle Disease ◽

Chemical Characterization ◽

Biological Evaluation ◽

Synthesis And Biological Evaluation

Synthesis and biological evaluation of some C-5 modified sialic acid glycals, epimerized or not at the C-4 position, as HN inhibitors of Newcastle Disease Virus (NDV).

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