Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

2011 ◽  
Vol 19 (13) ◽  
pp. 4067-4074 ◽  
Author(s):  
Christian Steuer ◽  
Christian Gege ◽  
Wolfgang Fischl ◽  
Karl H. Heinonen ◽  
Ralf Bartenschlager ◽  
...  
Keyword(s):  
Cell Culture ◽  
Antiviral Activity ◽  
Dengue Virus ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Thiazolidinone–Peptide Hybrids as Dengue Virus Protease Inhibitors with Antiviral Activity in Cell Culture

2013 ◽  
Vol 56 (21) ◽  
pp. 8389-8403 ◽  
Author(s):  
Christoph Nitsche ◽  
Verena N. Schreier ◽  
Mira A. M. Behnam ◽  
Anil Kumar ◽  
Ralf Bartenschlager ◽  
...  
Keyword(s):  
Cell Culture ◽  
Antiviral Activity ◽  
Dengue Virus ◽  
Protease Inhibitors

Synthesis and biological evaluation of novel rhodanine-based structures with antiviral activity towards HHV-6 virus

2021 ◽  
pp. 105518
Author(s):  
Valentina Gentili ◽  
Giulia Turrin ◽  
Paolo Marchetti ◽  
Sabrina Rizzo ◽  
Giovanna Schiuma ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Design, synthesis, and biological evaluation of novel 7-deazapurine nucleoside derivatives as potential anti-dengue virus agents

2018 ◽  
Vol 149 ◽  
pp. 95-105 ◽  
Author(s):  
Cai Lin ◽  
Jianchen Yu ◽  
Muzammal Hussain ◽  
Yiqian Zhou ◽  
Anna Duan ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Vinod Kumar Pandey ◽  
Zehra Tusi ◽  
Sumerah Tusi ◽  
Madhawanand Joshi
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antiviral Activity ◽  
Benzoic Acid ◽  
Carbon Disulphide ◽  
Antiviral Agents ◽  
Biological Evaluation ◽  
Herpes Simplex Virus 1 ◽  
Simplex Virus ◽  
Synthesis And Biological Evaluation

A series of novel 4-amino-5-mercapto-3-[(3-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazoles (5a-d) were obtained by treating m-(aralkyl amido/imidoalkyl) benzoic acid hydrazides (3a-d) with carbon disulphide in alcoholic KOH and hydrazine hydrate, respectively. These triazole derivatives were employed in the synthesis of 5-[(3′-aralkyl amido/imidoalkyl) phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines (6a-d). The newly synthesized compounds were evaluated for their antiviral activity against two animal viruses, namely, Japanese encephalitis virus (JEV) strain P20778 and herpes simplex virus-1 (HSV-1) strain 753166.

scholarly journals C-5’-Triazolyl-2’-oxa-3’-aza-4’a-carbanucleosides: Synthesis and biological evaluation

2015 ◽  
Vol 11 ◽  
pp. 328-334 ◽  
Author(s):  
Roberto Romeo ◽  
Caterina Carnovale ◽  
Salvatore V Giofrè ◽  
Maria A Chiacchio ◽  
Adriana Garozzo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Antitumor Activity ◽  
Antiviral Activity ◽  
Click Chemistry ◽  
Biological Evaluation ◽  
Biological Tests ◽  
Synthesis And Biological Evaluation ◽  
Inhibit Cell Proliferation

A novel series of 2’-oxa-3’-aza-4’a-carbanucleosides, featured with a triazole linker at the 5’-position, has been developed by exploiting a click chemistry reaction of 5’-azido-2’-oxa-3’-aza-4’a-carbanucleosides with substituted alkynes. Biological tests indicate an antitumor activity for the synthesized compounds: most of them inhibit cell proliferation of Vero, BS-C-1, HEp-2, MDCK, and HFF cells with a CC50 in the range of 5.0–40 μM. The synthesized compounds do not show any antiviral activity.

scholarly journals Synthesis and biological evaluation of novel urea and thiourea derivatives of valacyclovir

2014 ◽  
Vol 79 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Ramana Katla ◽  
Rasheed Syed ◽  
Madhava Golla ◽  
Adam Shaik ◽  
Raju Chamarthi
Keyword(s):  
Antioxidant Activity ◽  
Antiviral Activity ◽  
Elemental Analysis ◽  
Antioxidant Activities ◽  
Biological Evaluation ◽  
Thiourea Derivatives ◽  
Mass Spectral ◽  
High Yields ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

A series of novel urea and thiourea derivatives of valacyclovir were efficiently synthesized in high yields and evaluated their antiviral activity. 2-((6-Amino-4-oxo-4,5-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)methoxy)ethyl-2-amino-3-ethylbutanoate (valacyclovir) 1 is reacted with various aromatic isocyanates/thiocyanates 2 in the presence of N, N- dimethyl piperazine as a base in THF: pyridine (4:1) to obtain valacyclovir urea/thiourea derivatives 3(a-j). The structures of the title compounds 3(a-j) were confirmed by IR, NMR (1H, 13C), mass spectral and elemental analysis. The newly synthesized compounds were screened for their antiviral activity against Tobacco mosaic virus (TMV) and antioxidant activity was evaluated by DPPH, SOD and GST methods. The title compounds exhibited potent antiviral and good antioxidant activities.

Synthesis and biological evaluation of novel imidazole nucleosides as potential anti-dengue virus agents

2019 ◽  
Vol 27 (11) ◽  
pp. 2181-2186 ◽  
Author(s):  
Yuki Okano ◽  
Noriko Saito-Tarashima ◽  
Madoka Kurosawa ◽  
Ai Iwabu ◽  
Masashi Ota ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and chemical characterization of several perfluorinated sialic acid glycals and evaluation of their in vitro antiviral activity against Newcastle disease virus

MedChemComm ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 1505-1513 ◽  
Author(s):  
P. Rota ◽  
N. Papini ◽  
P. La Rocca ◽  
M. Montefiori ◽  
F. Cirillo ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Antiviral Activity ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Chemical Characterization ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of some C-5 modified sialic acid glycals, epimerized or not at the C-4 position, as HN inhibitors of Newcastle Disease Virus (NDV).

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