Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae

2016 ◽  
Vol 24 (16) ◽  
pp. 3413-3417 ◽  
Author(s):  
Sonia Del Prete ◽  
Daniela Vullo ◽  
Viviana De Luca ◽  
Vincenzo Carginale ◽  
Pietro di Fonzo ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Pathogenic Bacterium ◽  
Carbonic Anhydrases

scholarly journals Benzoxaboroles: New Potent Inhibitors of the Carbonic Anhydrases of the Pathogenic Bacterium Vibrio cholerae

2020 ◽  
Vol 11 (11) ◽  
pp. 2277-2284
Author(s):  
Alessandro Bonardi ◽  
Alessio Nocentini ◽  
Roberta Cadoni ◽  
Sonia del Prete ◽  
Pascal Dumy ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Pathogenic Bacterium ◽  
Carbonic Anhydrases

Acyl selenoureido benzensulfonamides show potent inhibitory activity against carbonic anhydrases from the pathogenic bacterium Vibrio cholerae

2017 ◽  
Vol 75 ◽  
pp. 170-172 ◽  
Author(s):  
Andrea Angeli ◽  
Ghulam Abbas ◽  
Sonia Del Prete ◽  
Fabrizio Carta ◽  
Clemente Capasso ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Inhibitory Activity ◽  
Pathogenic Bacterium ◽  
Carbonic Anhydrases ◽  
Potent Inhibitory Activity

scholarly journals Activation studies of the α- and β-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae with amines and amino acids

2017 ◽  
Vol 33 (1) ◽  
pp. 227-233 ◽  
Author(s):  
Andrea Angeli ◽  
Sonia Del Prete ◽  
Sameh M. Osman ◽  
Fatmah A. S. Alasmary ◽  
Zeid AlOthman ◽  
...  
Keyword(s):  
Amino Acids ◽  
Vibrio Cholerae ◽  
Pathogenic Bacterium ◽  
Carbonic Anhydrases

Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae

2016 ◽  
Vol 26 (8) ◽  
pp. 1941-1946 ◽  
Author(s):  
Sonia Del Prete ◽  
Daniela Vullo ◽  
Viviana De Luca ◽  
Vincenzo Carginale ◽  
Sameh M. Osman ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
Pathogenic Bacterium ◽  
Carbonic Anhydrases

scholarly journals Novel Indole-Based Hydrazones as Potent Inhibitors of the α-class Carbonic Anhydrase from Pathogenic Bacterium Vibrio cholerae

2020 ◽  
Vol 21 (9) ◽  
pp. 3131
Author(s):  
Kübra Demir-Yazıcı ◽  
Özlen Güzel-Akdemir ◽  
Andrea Angeli ◽  
Claudiu T. Supuran ◽  
Atilla Akdemir
Keyword(s):  
Vibrio Cholerae ◽  
Active Site ◽  
Selective Inhibition ◽  
Pathogenic Bacterium ◽  
Carbonic Anhydrases ◽  
Urgent Problem ◽  
Antimicrobial Drugs ◽  
Molecular Modeling Studies ◽  
Inhibitory Activities ◽  
Inhibition Studies

Due to the increasing resistance of currently used antimicrobial drugs, there is an urgent problem for the treatment of cholera disease, selective inhibition of the α-class carbonic anhydrases (CA, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae (VcCA) presents an alternative therapeutic target. In this study, a series of hydrazone derivatives, carrying the 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide scaffold, have been evaluated as inhibitors of the VcCA with molecular modeling studies. The results suggest that these compounds may bind to the active site of VcCA. To verify this, VcCA enzyme inhibition studies were performed and as predicted most of the tested compounds displayed potent inhibitory activities against VcCA with three compounds showing KI values lower than 30 nM. In addition, all these compounds showed selectivity for VcCA and the off-targets hCA I and II.

scholarly journals In Silico-Guided Identification of New Potent Inhibitors of Carbonic Anhydrases Expressed in Vibrio cholerae

2020 ◽  
Vol 11 (11) ◽  
pp. 2294-2299
Author(s):  
Francesca Mancuso ◽  
Laura De Luca ◽  
Andrea Angeli ◽  
Emanuela Berrino ◽  
Sonia Del Prete ◽  
...  
Keyword(s):  
Vibrio Cholerae ◽  
In Silico ◽  
Carbonic Anhydrases

The γ-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae is potently activated by amines and amino acids

2018 ◽  
Vol 77 ◽  
pp. 1-5 ◽  
Author(s):  
Andrea Angeli ◽  
Sonia Del Prete ◽  
William A. Donald ◽  
Clemente Capasso ◽  
Claudiu T. Supuran
Keyword(s):  
Amino Acids ◽  
Carbonic Anhydrase ◽  
Vibrio Cholerae ◽  
Pathogenic Bacterium

scholarly journals Identification of Multiple ς54-Dependent Transcriptional Activators inVibrio cholerae

1998 ◽  
Vol 180 (19) ◽  
pp. 5256-5259 ◽  
Author(s):  
Karl E. Klose ◽  
Veronica Novik ◽  
John J. Mekalanos
Keyword(s):  
Quorum Sensing ◽  
Vibrio Cholerae ◽  
Sigma Factor ◽  
Pathogenic Bacterium ◽  
Transcriptional Activators ◽  
High Homology ◽  
Chromosomal Dna ◽  
Degenerate Primers ◽  
Coding Sequences ◽  
Mutant Strains

ABSTRACT In the pathogenic bacterium Vibrio cholerae, the alternate sigma factor ς54 is required for expression of multiple sets of genes, including an unidentified gene(s) necessary for enhanced colonization within the host. To identify ς54-dependent transcriptional activators involved in colonization, PCR was performed with V. choleraechromosomal DNA and degenerate primers, revealing six novel and distinct coding sequences with homology to ς54-dependent activators. One sequence had high homology to the luxO gene of V. harveyi, which in that organism is involved in quorum sensing. Phenotypes of V. cholerae strains containing mutations in each of the six putative ς54-dependent activator genes identified one as a probable ntrChomologue. None of the mutant strains exhibited a defect in the ability to colonize infant mice, suggesting the presence of additional ς54-dependent activators not identified by this technique.

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