scholarly journals Structure–activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus

2008 ◽  
Vol 18 (15) ◽  
pp. 4294-4297 ◽  
Author(s):  
Joseph I. Ambrus ◽  
Michael J. Kelso ◽  
John B. Bremner ◽  
Anthony R. Ball ◽  
Gabriele Casadei ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Efflux Pump ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Structure-activity relationships of 3-substituted-5,5- diphenylhydantoins as potential antiproliferative and antimicrobial agents

2011 ◽  
Vol 76 (12) ◽  
pp. 1597-1606 ◽  
Author(s):  
Nemanja Trisovic ◽  
Bojan Bozic ◽  
Ana Obradovic ◽  
Olgica Stefanovic ◽  
Snezana Markovic ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Agents ◽  
Human Colon ◽  
Antibacterial Activities ◽  
E Coli ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Almost All

A series of twelve 3-substituted-5,5-diphenylhydantoins was synthesized, including some whose anticonvulsant activities have already been reported in the literature. Their antiproliferative activities against HCT-116 human colon carcinoma cells were evaluated to determine structure-activity relationships. Almost all of the compounds exhibited statistically significant antiproliferative effects at a concentration of 100 ?M, while the derivative bearing a benzyl group was active even at lower concentrations. Moreover, their in vitro antibacterial activities against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923 and clinical isolates of Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Enterococcus faecalis and Staphylococcus aureus were evaluated. Only the 3-iso-propyl and 3-benzyl derivatives showed weak antibacterial activities against the Gram-positive bacterium E. faecalis and the Gram-negative bacteria E. coli ATCC 25922 and E. coli.

Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure–activity relationships of (N-methyl-piperazinyl)-containing derivatives

2004 ◽  
Vol 14 (20) ◽  
pp. 5133-5137 ◽  
Author(s):  
William J. Watkins ◽  
Rémy C. Lemoine ◽  
Lee Chong ◽  
Aesop Cho ◽  
Thomas E. Renau ◽  
...  
Keyword(s):  
Efflux Pump ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Efflux Pump Inhibitors

scholarly journals Structure–activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors

2015 ◽  
Vol 23 (9) ◽  
pp. 2024-2034 ◽  
Author(s):  
Son T. Nguyen ◽  
Steven M. Kwasny ◽  
Xiaoyuan Ding ◽  
Steven C. Cardinale ◽  
Courtney T. McCarthy ◽  
...  
Keyword(s):  
Efflux Pump ◽  
Gram Negative ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Efflux Pump Inhibitors
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