Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy

2009 ◽  
Vol 19 (4) ◽  
pp. 1177-1182 ◽  
Author(s):  
Stephen A. Thomson ◽  
Pierette Banker ◽  
D. Mark Bickett ◽  
Joyce A. Boucheron ◽  
H. Luke Carter ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycogen Phosphorylase ◽  
In Vivo Efficacy ◽  
X Ray ◽  
Glycogen Phosphorylase Inhibitors

Pentacyclic triterpenes, inhibitors of glycogen phosphorylase, as potential drugs for type 2 diabetes: X-ray crystallographic studies

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
SE Zographos ◽  
DD Leonidas ◽  
KM Alexacou ◽  
T Gimisis ◽  
JM Hayes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycogen Phosphorylase ◽  
X Ray ◽  
Pentacyclic Triterpenes

Phytogenic Polyphenols as Glycogen Phosphorylase Inhibitors: The Potential of Triterpenes and Flavonoids for Glycaemic Control in Type 2 Diabetes

2017 ◽  
Vol 24 (4) ◽  
pp. 384-403 ◽  
Author(s):  
Demetres Leonidas ◽  
Joseph Hayes ◽  
Atsushi Kato ◽  
Vassiliki Skamnaki ◽  
Demetra Chatzileontiadou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycaemic Control ◽  
Glycogen Phosphorylase ◽  
Glycogen Phosphorylase Inhibitors

scholarly journals Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition

2020 ◽  
Vol 18 (5) ◽  
pp. 931-940 ◽  
Author(s):  
David Goyard ◽  
Bálint Kónya ◽  
Katalin Czifrák ◽  
Paolo Larini ◽  
Fanny Demontrond ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycogen Phosphorylase ◽  
Diabetic Rat ◽  
Rat Models ◽  
New Treatment

Spiro-glyco-heterocycles were prepared on a gram scale from a thiolactone obtained by thermolysis of a thiosulfinate. Lowering of glycaemia in diabetic rat models is pointing toward potential new treatment of type 2 diabetes.

Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes

2005 ◽  
Vol 48 (20) ◽  
pp. 6178-6193 ◽  
Author(s):  
Thomas Klabunde ◽  
K. Ulrich Wendt ◽  
Dieter Kadereit ◽  
Volker Brachvogel ◽  
Hans-Jörg Burger ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Human Liver ◽  
Glycogen Phosphorylase ◽  
Liver Glycogen ◽  
Glycogen Phosphorylase Inhibitors
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