Prevention of breast cancer cell adhesion to bone in vitro by bisphosphonates is mediated by their inhibitory effect on protein prenylation

Bone ◽  
2006 ◽  
Vol 38 (3) ◽  
pp. 59-60 ◽  
Author(s):  
Sweyn Garrioch ◽  
Anke J. Roelofs ◽  
F. Hal Ebetino ◽  
Michael J. Rogers
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Inhibitory Effect ◽  
Protein Prenylation ◽  
Cancer Cell Adhesion ◽  
Prevention Of Breast Cancer

IGF-I/EGF and E2 signaling crosstalk through IGF-IR conduit point affects breast cancer cell adhesion

2016 ◽  
Vol 56 ◽  
pp. 95-113 ◽  
Author(s):  
Kallirroi Voudouri ◽  
Dragana Nikitovic ◽  
Aikaterini Berdiaki ◽  
Dimitris Kletsas ◽  
Nikos K. Karamanos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Signaling Crosstalk ◽  
Cancer Cell Adhesion ◽  
Igf I

scholarly journals The role of angiotensin II in the regulation of breast cancer cell adhesion and invasion

2006 ◽  
Vol 13 (3) ◽  
pp. 895-903 ◽  
Author(s):  
J R Puddefoot ◽  
U K I Udeozo ◽  
S Barker ◽  
G P Vinson
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Angiotensin Ii ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Progression ◽  
Renin Angiotensin System ◽  
Adhesion And Invasion

As breast cancer remains the most common cause of cancer death in women, there is a continuing need not only to further characterise the processes of cancer progression, but also to improve accuracy of prognostic markers. Breast epithelial cells express components of the renin angiotensin system and studies suggest that these may be altered in disease progression. In addition, altered integrin expression correlates with lymph node metastasis. The aim of this study was to investigate the relationship between angiotensin II (AII) and integrins in breast tissue and, in particular, their role in breast cancer cell metastasis. Using in vitro assays, AII (10−6 M)-treated MCF-7 and T47D breast cancer cells both show reduced adhesion to extracellular matrix proteins collagen-, fibronectin- and laminin-coated wells (P<0.001) and reduced invasion through collagen-, fibronectin- and laminin-coated membranes (P<0.05). This action was inhibited by co-treatment with the angiotensin type 1 receptor (AT1R) antagonist losartan (10−5 M). The addition of the AT2R inhibitor PD123319 (10−5 M) to AII-treated cells had no significant effect. Semi-quantitative reverse transcriptase-PCR and western blotting revealed that cells treated with AII (10−6 M) expressed lower levels of both integrin α3 and β1. Using specific inhibitors, this was shown to occur through protein kinase C signalling. These data suggest that AII reduces cell adhesion and invasion through the type 1 receptor and that this effect may be due to reduced expression of integrins, and in particular α3 and β1.

scholarly journals Inhibition of breast cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus

2007 ◽  
Vol 357 (1) ◽  
pp. 282-288 ◽  
Author(s):  
Darius Schneider ◽  
Lucy Liaw ◽  
Carolin Daniel ◽  
Athanasios N. Athanasopoulos ◽  
Mathias Herrmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Staphylococcus Aureus ◽  
Cell Adhesion ◽  
Bone Metastasis ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Adhesion

scholarly journals Intrafibrillar, bone-mimetic collagen mineralization regulates breast cancer cell adhesion and migration

Biomaterials ◽  
2019 ◽  
Vol 198 ◽  
pp. 95-106 ◽  
Author(s):  
Siyoung Choi ◽  
Jens Friedrichs ◽  
Young Hye Song ◽  
Carsten Werner ◽  
Lara A. Estroff ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Adhesion ◽  
Cell Adhesion And Migration ◽  
Collagen Mineralization ◽  
And Migration

scholarly journals Sodium phenylacetate enhances the inhibitory effect of dextran derivative on breast cancer cell growth in vitro and in nude mice

2001 ◽  
Vol 85 (6) ◽  
pp. 917-923 ◽  
Author(s):  
M Di Benedetto ◽  
Y Kourbali ◽  
A Starzec ◽  
R Vassy ◽  
J Jozefonvicz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Nude Mice ◽  
Inhibitory Effect ◽  
Cancer Cell Growth ◽  
Breast Cancer Cell Growth ◽  
Sodium Phenylacetate
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