scholarly journals Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage

Bone ◽  
2016 ◽  
Vol 85 ◽  
pp. 29-36 ◽  
Author(s):  
Lakshman Singh ◽  
Tracy A. Brennan ◽  
Elizabeth Russell ◽  
Jung-Hoon Kim ◽  
Qijun Chen ◽  
...  
Keyword(s):  
Cell Fate ◽  
Precursor Cell ◽  
Mesenchymal Precursor Cell ◽  
Mesenchymal Precursor

scholarly journals The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70

Stem Cells ◽  
2017 ◽  
Vol 35 (4) ◽  
pp. 940-951 ◽  
Author(s):  
Stephen Fitter ◽  
Stan Gronthos ◽  
Soo Siang Ooi ◽  
Andrew C.W. Zannettino
Keyword(s):  
Heat Shock ◽  
Cell Surface ◽  
Surface Heat ◽  
Precursor Cell ◽  
Cell Marker ◽  
Heat Shock Cognate 70 ◽  
Mesenchymal Precursor Cell ◽  
Mesenchymal Precursor

DNA-damage, survival, differentiation, and matrix mineralization in vitro of a murine multipotent mesenchymal precursor cell line

2013 ◽  
Author(s):  
Patrick Lau ◽  
Yueyuan Hu ◽  
Christine E Hellweg ◽  
Christa Baumstark-Khan ◽  
Gunther Reitz
Keyword(s):  
Dna Damage ◽  
Cell Line ◽  
Precursor Cell ◽  
Matrix Mineralization ◽  
Precursor Cell Line ◽  
Mesenchymal Precursor Cell ◽  
Mesenchymal Precursor

scholarly journals G-CSF increases mesenchymal precursor cell numbers in the bone marrow via an indirect mechanism involving osteoclast-mediated bone resorption

2010 ◽  
Vol 5 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Nathalie Brouard ◽  
Rebecca Driessen ◽  
Brenton Short ◽  
Paul J. Simmons
Keyword(s):  
Bone Marrow ◽  
Bone Resorption ◽  
Precursor Cell ◽  
Cell Numbers ◽  
Indirect Mechanism ◽  
Mesenchymal Precursor Cell ◽  
Mesenchymal Precursor

Implantation of a Novel Allogeneic Mesenchymal Precursor Cell Type in Patients with Ischemic Cardiomyopathy Undergoing Coronary Artery Bypass Grafting: an Open Label Phase IIa Trial

2016 ◽  
Vol 9 (3) ◽  
pp. 202-213 ◽  
Author(s):  
Kyriakos Anastasiadis ◽  
Polychronis Antonitsis ◽  
Stephen Westaby ◽  
Ajan Reginald ◽  
Sabena Sultan ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Ischemic Cardiomyopathy ◽  
Artery Bypass ◽  
Precursor Cell ◽  
Bypass Grafting ◽  
Cell Type ◽  
Open Label ◽  
Open Label Phase ◽  
Mesenchymal Precursor Cell ◽  
Mesenchymal Precursor

scholarly journals BMPR1A is necessary for chondrogenesis and osteogenesis, whereas BMPR1B prevents hypertrophic differentiation

2020 ◽  
Vol 133 (16) ◽  
pp. jcs246934 ◽  
Author(s):  
Tanja Mang ◽  
Kerstin Kleinschmidt-Doerr ◽  
Frank Ploeger ◽  
Andreas Schoenemann ◽  
Sven Lindemann ◽  
...  
Keyword(s):  
Cell Line ◽  
Precursor Cell ◽  
Osteosarcoma Cell ◽  
Wild Type ◽  
Human Osteosarcoma Cell Line ◽  
Human Osteosarcoma ◽  
Precursor Cell Line ◽  
Human Osteosarcoma Cell ◽  
Mesenchymal Precursor Cell ◽  
Mesenchymal Precursor

ABSTRACTBMP2 stimulates bone formation and signals preferably through BMP receptor (BMPR) 1A, whereas GDF5 is a cartilage inducer and signals preferably through BMPR1B. Consequently, BMPR1A and BMPR1B are believed to be involved in bone and cartilage formation, respectively. However, their function is not yet fully clarified. In this study, GDF5 mutants with a decreased affinity for BMPR1A were generated. These mutants, and wild-type GDF5 and BMP2, were tested for their ability to induce dimerization of BMPR1A or BMPR1B with BMPR2, and for their chondrogenic, hypertrophic and osteogenic properties in chondrocytes, in the multipotent mesenchymal precursor cell line C3H10T1/2 and the human osteosarcoma cell line Saos-2. Mutants with the lowest potency for inducing BMPR1A–BMPR2 dimerization exhibited minimal chondrogenic and osteogenic activities, indicating that BMPR1A is necessary for chondrogenic and osteogenic differentiation. BMP2, GDF5 and the GDF5 R399E mutant stimulated expression of chondrogenic and hypertrophy markers in C3H10T1/2 cells and chondrocytes. However, GDF5 R399E, which induces the dimerization of BMPR1B and BMPR2 more potently than GDF5 or BMP2, displayed reduced hypertrophic activity. Therefore, we postulate that stronger BMPR1B signaling, compared to BMPR1A signaling, prevents chondrocyte hypertrophy and acts as a cartilage stabilizer during joint morphogenesis.This article has an associated First Person interview with the first author of the paper.

scholarly journals Smad5 and DPC4 Are Key Molecules in Mediating BMP-2-induced Osteoblastic Differentiation of the Pluripotent Mesenchymal Precursor Cell Line C2C12

1998 ◽  
Vol 273 (4) ◽  
pp. 1872-1879 ◽  
Author(s):  
Riko Nishimura ◽  
Yoichi Kato ◽  
Di Chen ◽  
Stephen E. Harris ◽  
Gregory R. Mundy ◽  
...  
Keyword(s):  
Cell Line ◽  
Osteoblastic Differentiation ◽  
Precursor Cell ◽  
Precursor Cell Line ◽  
Mesenchymal Precursor Cell ◽  
Mesenchymal Precursor
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