Mechanical loading and parathyroid hormone effects and synergism in bone vary by site and modeling/remodeling regime

Bone ◽  
2021 ◽  
Vol 153 ◽  
pp. 116171
Author(s):  
Samuel T. Robinson ◽  
Peter T. Shyu ◽  
X. Edward Guo
Keyword(s):  
Parathyroid Hormone ◽  
Mechanical Loading ◽  
Hormone Effects

Parathyroid Hormone Effects in Rats Treated with Diphosphonate

Science ◽  
1974 ◽  
Vol 183 (4125) ◽  
pp. 661-663 ◽  
Author(s):  
R. V. Talmage ◽  
J. J. B. Anderson
Keyword(s):  
Parathyroid Hormone ◽  
Hormone Effects

Erratum to “Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice” [Bone 43 (2008) 238–248]

Bone ◽  
2009 ◽  
Vol 45 (6) ◽  
pp. 1192-1195
Author(s):  
Toshihiro Sugiyama ◽  
Leanne K. Saxon ◽  
Gul Zaman ◽  
Alaa Moustafa ◽  
Andrew Sunters ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Cortical Bone ◽  
Mechanical Loading

Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration

Peptides ◽  
2002 ◽  
Vol 23 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Doug Throckmorton ◽  
Doris Kurscheid-Reich ◽  
Oscar R Rosales ◽  
Jose Rodriguez-Commes ◽  
Raquel Lopez ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Parathyroid Hormone ◽  
Signaling Pathways ◽  
Peptide Concentration ◽  
Hormone Effects

scholarly journals Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Nicole R Gould ◽  
Katrina M Williams ◽  
Humberto C Joca ◽  
Olivia M Torre ◽  
James S Lyons ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Formation ◽  
Signaling Pathway ◽  
Mouse Models ◽  
Cell Lines ◽  
Mechanical Loading ◽  
Gaucher Disease ◽  
Mechanical Load ◽  
Lysosomal Degradation ◽  
Rodent Cell

The down regulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the Sost gene hours after stimulation. Using mouse models and rodent cell lines, we describe the rapid, minutes-scale post-translational degradation of sclerostin protein by the lysosome following mechanical load and PTH. We present a model, integrating both new and established mechanically- and hormonally-activated effectors into the regulated degradation of sclerostin by lysosomes. Using a mouse forelimb mechanical loading model, we find transient inhibition of lysosomal degradation or the upstream mechano-signaling pathway controlling sclerostin abundance impairs subsequent load-induced bone formation by preventing sclerostin degradation. We also link dysfunctional lysosomes to aberrant sclerostin regulation using human Gaucher disease iPSCs. These results reveal how bone anabolic cues post-translationally regulate sclerostin abundance in osteocytes to regulate bone formation.

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