scholarly journals High-Pressure Microscopy for Modulating the Structure and Function of Biomolecules

2010 ◽  
Vol 98 (3) ◽  
pp. 182a
Author(s):  
Masayoshi Nishiyama ◽  
Yoshifumi Kimura ◽  
Masahide Terazima
2008 ◽  
Vol 74 (24) ◽  
pp. 7821-7823 ◽  
Author(s):  
Kai Linke ◽  
Nagarajan Periasamy ◽  
Matthias Ehrmann ◽  
Roland Winter ◽  
Rudi F. Vogel

ABSTRACT High hydrostatic pressure (HHP) is suggested to influence the structure and function of membranes and/or integrated proteins. We demonstrate for the first time HHP-induced dimer dissociation of membrane proteins in vivo with Vibrio cholerae ToxR variants in Escherichia coli reporter strains carrying ctx::lacZ fusions. Dimerization ceased at 20 to 50 MPa depending on the nature of the transmembrane segments rather than on changes in the ToxR lipid bilayer environment.


It is challenging indeed to be invited to introduce this broad-ranging session, for it encompasses virtually all levels of the effects of pressure and its antagonism by narcotics from the molecule to man. The papers will take us from the talk of Dr A. MacDonald on the reversible effects of pressure on molecules, and thereby cell structure and function, (MacDonald 1982) to Dr K. Miller and his co-workers, who will discuss the action of pressure on membranes and mammals such as mice to produce the high pressure nervous syndrome.


1996 ◽  
Vol 26 (3-5) ◽  
pp. 414-415
Author(s):  
Andrzej Krzyżaniak ◽  
Piotr Sałański ◽  
Janusz Jurczak ◽  
Jan Barciszewski

Author(s):  
Frédéric Bancel ◽  
Gaston Hui Bon Hoa ◽  
Pavel Anzenbacher ◽  
Claude Balny ◽  
Reinhard Lange

2006 ◽  
Vol 62 (a1) ◽  
pp. s113-s113
Author(s):  
R. J. Angel ◽  
M. Bujak ◽  
C. Slebodnick ◽  
J. Zhao ◽  
B. Hanson

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