scholarly journals Electrophysiological and Gene Expression Profiling at Single Cell Level through an Improved Whole Cell Patch Clamp Quantitative Real-Time PCR Technique

2012 ◽  
Vol 102 (3) ◽  
pp. 136a-137a
Author(s):  
Ken Veys ◽  
Alain J. Labro ◽  
Dirk J. Snyders
Keyword(s):  
Gene Expression ◽  
Patch Clamp ◽  
Single Cell ◽  
Gene Expression Profiling ◽  
Real Time Pcr ◽  
Expression Profiling ◽  
Single Cell Level ◽  
Quantitative Real Time Pcr ◽  
Cell Level ◽  
Whole Cell Patch Clamp

scholarly journals In Vivo Whole-Cell Patch-Clamp Methods: Recent Technical Progress and Future Perspectives

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1448
Author(s):  
Asako Noguchi ◽  
Yuji Ikegaya ◽  
Nobuyoshi Matsumoto
Keyword(s):  
Patch Clamp ◽  
Single Cell ◽  
Single Cell Level ◽  
Patch Clamp Recording ◽  
Cell Level ◽  
Whole Cell ◽  
Cell Patch Clamp ◽  
Whole Cell Patch Clamp ◽  
Recording Techniques

Brain functions are fundamental for the survival of organisms, and they are supported by neural circuits consisting of a variety of neurons. To investigate the function of neurons at the single-cell level, researchers often use whole-cell patch-clamp recording techniques. These techniques enable us to record membrane potentials (including action potentials) of individual neurons of not only anesthetized but also actively behaving animals. This whole-cell recording method enables us to reveal how neuronal activities support brain function at the single-cell level. In this review, we introduce previous studies using in vivo patch-clamp recording techniques and recent findings primarily regarding neuronal activities in the hippocampus for behavioral function. We further discuss how we can bridge the gap between electrophysiology and biochemistry.

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