scholarly journals Quantification of metabotropic glutamate receptor 5 availability with both [11C]ABP688 and [18F]FPEB positron emission tomography in the Sapap3 knockout mouse model for obsessive compulsive-like behavior

2021 ◽  
Author(s):  
Dorien Glorie ◽  
Jeroen Verhaeghe ◽  
Alan Miranda ◽  
Stef De Lombaerde ◽  
Sigrid Stroobants ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Mouse Model ◽  
Knockout Mouse ◽  
Metabotropic Glutamate Receptor ◽  
Emission Tomography ◽  
Obsessive Compulsive ◽  
Metabotropic Glutamate Receptor 5 ◽  
Knockout Mouse Model ◽  
Metabotropic Glutamate ◽  
Positron Emission

scholarly journals Microbiome Profiling Reveals Gut Dysbiosis in the Metabotropic Glutamate Receptor 5 Knockout Mouse Model of Schizophrenia

2020 ◽  
Vol 8 ◽  
Author(s):  
Carolina Gubert ◽  
Geraldine Kong ◽  
Volkan Uzungil ◽  
Ariel M. Zeleznikow-Johnston ◽  
Emma L. Burrows ◽  
...  
Keyword(s):  
Mouse Model ◽  
Glutamate Receptor ◽  
Knockout Mouse ◽  
Metabotropic Glutamate Receptor ◽  
Metabotropic Glutamate Receptor 5 ◽  
Knockout Mouse Model ◽  
Metabotropic Glutamate ◽  
Gut Dysbiosis ◽  
Microbiome Profiling

scholarly journals Radiosynthesis and Evaluation of an18F-Labeled Positron Emission Tomography (PET) Radioligand for Metabotropic Glutamate Receptor Subtype 4 (mGlu4)

2014 ◽  
Vol 57 (21) ◽  
pp. 9130-9138 ◽  
Author(s):  
Kun-Eek Kil ◽  
Pekka Poutiainen ◽  
Zhaoda Zhang ◽  
Aijun Zhu ◽  
Ji-Kyung Choi ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Emission Tomography ◽  
Receptor Subtype ◽  
Metabotropic Glutamate ◽  
Positron Emission

Therapeutic Exploration of Metabotropic Glutamate Receptor Antagonists in Parkinson’s Disease by Positron Emission Tomography

US Neurology ◽  
2010 ◽  
Vol 05 (02) ◽  
pp. 21
Author(s):  
Rosario Sanchez-Pernaute ◽  
Anna-Liisa Brownell ◽  
◽  
Keyword(s):  
Positron Emission Tomography ◽  
Synaptic Plasticity ◽  
Metabotropic Glutamate Receptor ◽  
Mrna Translation ◽  
Synaptic Function ◽  
Emission Tomography ◽  
Metabotropic Glutamate ◽  
Positron Emission ◽  
Mglu5 Receptors

Metabotropic glutamate receptors (mGluR)s are G-protein-coupled receptors that function as modulators of synaptic function and glutamate transmission. Post-synaptically localized subtype 5 mGlu5 receptors are co-localized with adenosine A2a, dopamine, and N-methyl-D-aspartate (NMDA) receptors and regulate local protein synthesis and messenger RNA (mRNA) translation at synapses, and are thus ideally positioned to control synaptic plasticity. Aberrant synaptic plasticity appears to be involved in a number of developmental and degenerative neuropsychiatric disorders, including Parkinson’s disease. Pharmacological modulation of mGluR5 could potentially open new therapeutic avenues for the treatment of such disorders, for both symptomatic and neuroprotective purposes. In this review, we summarize a series ofin vivostudies we performed in order to delineate the anatomical basis and functional role of mGluR5 antagonists in Parkinson’s disease models, taking advantage of high-resolution positron emission tomography (PET) and the recent development of novel specific radiopharmaceuticals. Our findings of a prevalent distribution of mGluR5 in the striatum and limbic structures and a significant binding enhancement following dopamine lesions support the role of mGlu5 receptors in modulating dopamine- and glutamate-dependent signaling and synaptic plasticity within the basal ganglia cortico–subcortical loops.

Synthesis, radiolabeling, in vitro and in vivo evaluation of [18F]-FPECMO as a positron emission tomography radioligand for imaging the metabotropic glutamate receptor subtype 5

2009 ◽  
Vol 36 (6) ◽  
pp. 613-622 ◽  
Author(s):  
Christophe Lucatelli ◽  
Michael Honer ◽  
Jean-Frédéric Salazar ◽  
Tobias L. Ross ◽  
P. August Schubiger ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Emission Tomography ◽  
Receptor Subtype ◽  
In Vivo Evaluation ◽  
Metabotropic Glutamate ◽  
Positron Emission

Preclinical and the first clinical studies on [11C]ITMM for mapping metabotropic glutamate receptor subtype 1 by positron emission tomography

2013 ◽  
Vol 40 (2) ◽  
pp. 214-220 ◽  
Author(s):  
Jun Toyohara ◽  
Muneyuki Sakata ◽  
Masayuki Fujinaga ◽  
Tomoteru Yamasaki ◽  
Keiichi Oda ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Glutamate Receptor ◽  
Clinical Studies ◽  
Metabotropic Glutamate Receptor ◽  
Emission Tomography ◽  
Receptor Subtype ◽  
Metabotropic Glutamate ◽  
Positron Emission
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