Antisense in vivo knockdown of synaptotagmin I by HVJ–liposome mediated gene transfer attenuates ischemic brain damage in neonatal rats

2008 ◽  
Vol 30 (5) ◽  
pp. 313-320 ◽  
Author(s):  
Tadaki Omae ◽  
Hiroshi Yoshioka ◽  
Taro Tanaka ◽  
Hideyuki Nagai ◽  
Makoto Saji ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Brain Damage ◽  
Neonatal Rats ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Synaptotagmin I

scholarly journals TERT Promotes Neurogenesis and Neural Repair after Hypoxic Ischemic Brain Damage in Neonatal Rats

2021 ◽  
Author(s):  
Jiao Li ◽  
Hai-ting Liu ◽  
Jing Zhao ◽  
Zhi Fang
Keyword(s):  
Developmental Stage ◽  
Brain Damage ◽  
Neurological Function ◽  
Cell Counting ◽  
Neonatal Rats ◽  
Ischemic Brain Damage ◽  
Neural Repair ◽  
Ischemic Brain

Abstract Neonatal hypoxic ischemic encephalopathy (HIE) endangers quality of life in children; but effective cure is rare. Neurogenesis plays an important role in neural repair following brain damage. Recent studies have demonstrated that telomerase reverse transcriptase (TERT) was involved in neurogenesis regulation. However, whether TERT participates in the regulation of neurogenesis after hypoxic-ischemic brain damage (HIBD) is unclear. Here, we established a model of HIBD in neonatal rats both in vivo and in vitro, and used lentivirus and adenovirus transfection for TERT overexpression to investigate its role in neurogenesis after HIBD in developmental stage. Using immunofluorescence staining, cell counting Kit-8 staining, TUNEL, and western blotting, we observed that TERT attenuated apoptosis and promoted proliferation, migration, and differentiation in neural stem cells (NSCs). Furthermore, TERT induced myelination in the brain of neonatal rats after HIBD. Neurobehavioral tests revealed that TERT could improve learning, memory, and neurological function after HIBD in neonatal rats, and thus promote the recovery of neurological function after HIBD. In addition, we investigated the regulatory mechanism of TERT during neurogenesis after HIBD in developmental stage. We found that TERT may regulate neurogenesis after HIBD through the Sonic Hedgehog/Gli1 signaling pathway. Our study demonstrated that TERT could promote neural repair and neurological function recovery after HIBD in neonatal rats. The new neuroprotective pathway regulated by TERT during HIBD described here could provide a basis for developing therapeutic strategy for neonatal HIE. Furthermore, TERT may be a potential target during neural repair and reconstruction in various diseases affecting nervous system.

scholarly journals Intraventricular Injection of Human Dental Pulp Stem Cells Improves Hypoxic-Ischemic Brain Damage in Neonatal Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66748 ◽  
Author(s):  
Cheng-zhi Fang ◽  
Yu-jia Yang ◽  
Qin-hong Wang ◽  
Yue Yao ◽  
Xiao-ying Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Damage ◽  
Dental Pulp ◽  
Dental Pulp Stem Cells ◽  
Intraventricular Injection ◽  
Neonatal Rats ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Human Dental Pulp

Progesterone inhibits the expression of cycloxygenase-2 and interleukin-1β in neonatal rats with hypoxic ischemic brain damage

2013 ◽  
Vol 124 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Xiaoyin Wang ◽  
Junhe Zhang ◽  
Daowen Si ◽  
Ruling Shi ◽  
Weihua Dong ◽  
...  
Keyword(s):  
Brain Damage ◽  
Interleukin 1Β ◽  
Neonatal Rats ◽  
Ischemic Brain Damage ◽  
Ischemic Brain

Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effect

1994 ◽  
Vol 257 (1-2) ◽  
pp. 131-136 ◽  
Author(s):  
Takahiro Hayakawa ◽  
Yoshihisa Higuchi ◽  
Hiroyuki Nigami ◽  
Haruo Hattori
Keyword(s):  
Brain Damage ◽  
Neonatal Rats ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Anticonvulsive Effect

Studies on cerebral protection of digoxin against hypoxic–ischemic brain damage in neonatal rats

Neuroreport ◽  
2016 ◽  
Vol 27 (12) ◽  
pp. 906-915 ◽  
Author(s):  
Kaiwei Peng ◽  
Danfeng Tan ◽  
Miao He ◽  
Dandan Guo ◽  
Juan Huang ◽  
...  
Keyword(s):  
Brain Damage ◽  
Cerebral Protection ◽  
Neonatal Rats ◽  
Ischemic Brain Damage ◽  
Ischemic Brain
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