Difference in amplitude of low-frequency fluctuation between currently depressed and remitted females with major depressive disorder

2013 ◽  
Vol 1540 ◽  
pp. 74-83 ◽  
Author(s):  
Bin Jing ◽  
Chun-Hong Liu ◽  
Xin Ma ◽  
Hua-Gang Yan ◽  
Zhi-Zheng Zhuo ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Low Frequency ◽  
Frequency Fluctuation ◽  
Major Depressive

scholarly journals Altered Fractional Amplitude of Low-Frequency Fluctuation in Major Depressive Disorder and Bipolar Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Yan Qiu ◽  
Min Yang ◽  
Sujuan Li ◽  
Ziwei Teng ◽  
Kun Jin ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Pearson Correlation ◽  
Low Frequency ◽  
Frequency Fluctuation ◽  
Middle Temporal Gyrus ◽  
Support Vector ◽  
Major Depressive ◽  
The Right

Background: Discriminating between major depressive disorder (MDD) and bipolar disorder (BD) remains challenging and cognitive deficits in MDD and BD are generally recognized. In this study, the fractional amplitude of low-frequency fluctuation (fALFF) approach was performed to explore neural activity and cognition in first-episode, drug-naïve BD and MDD patients, as well as the relationship between altered fALFF values and clinical or psychometric variables.Methods: A total of 21 BD patients, 25 MDD patients, and 41 healthy controls (HCs) completed clinical assessments and resting-state functional magnetic resonance imaging (rs-fMRI) scans in this study. The rs-fMRI data were analyzed by fALFF method and Pearson correlation analyses were performed between altered fALFF values and clinical variables or cognition. Support vector machine (SVM) was adopted to identify the three groups from each other with abnormal fALFF values in the brain regions obtained by group comparisons.Results: (1) The fALFF values were significantly different in the frontal lobe, temporal lobe, and left precuneus among three groups. In comparison to HCs, BD showed increased fALFF values in the right inferior temporal gyrus (ITG) and decreased fALFF values in the right middle temporal gyrus, while MDD showed decreased fALFF values in the right cerebellar lobule IV/V. In comparison to MDD, BD showed decreased fALFF values in bilateral posterior cingulate gyrus and the right cerebellar lobule VIII/IX. (2) In the BD group, a negative correlation was found between increased fALFF values in the right ITG and years of education, and a positive correlation was found between decreased fALFF values in the right cerebellar lobule VIII/IX and visuospatial abilities. (3) The fALFF values in the right cerebellar lobule VIII/IX may have the ability to discriminate BD patients from MDD patients, with sensitivity, specificity, and accuracy all over 0.70.Conclusions: Abnormal brain activities were observed in BD and MDD and were related with cognition in BD patients. The abnormality in the cerebellum can be potentially used to identify BD from MDD patients.

scholarly journals Low-frequency and rare variants may contribute to elucidate the genetics of major depressive disorder

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Chenglong Yu ◽  
Mauricio Arcos-Burgos ◽  
Bernhard T. Baune ◽  
Volker Arolt ◽  
Udo Dannlowski ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Rare Variants ◽  
Low Frequency ◽  
Major Depressive

scholarly journals Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhuoying Wu ◽  
Qianyi Luo ◽  
Huawang Wu ◽  
Zhiyao Wu ◽  
Yingjun Zheng ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Childhood Trauma ◽  
Low Frequency ◽  
Anterior Cingulate ◽  
Dorsal Anterior Cingulate Cortex ◽  
Major Depressive ◽  
Significant Group ◽  
Group Frequency ◽  
Left Insula

Major Depressive Disorder (MDD) with childhood trauma is one of the functional subtypes of depression. Frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) have been reported in MDD patients. However, there are few studies on ALFF about MDD with childhood trauma. Resting-state functional magnetic resonance imaging was used to measure the ALFF in 69 MDD patients with childhood trauma (28.7 ± 9.6 years) and 30 healthy subjects (28.12 ± 4.41 years). Two frequency bands (slow-5: 0.010–0.027 Hz; slow-4: 0.027–0.073 Hz) were analyzed. Compared with controls, the MDD with childhood trauma had decreased ALFF in left S1 (Primary somatosensory cortex), and increased ALFF in left insula. More importantly, significant group × frequency interactions were found in right dorsal anterior cingulate cortex (dACC). Our finding may provide insights into the pathophysiology of MDD with childhood trauma.

scholarly journals Is there any difference in the fractional amplitude of low-frequency fluctuations between first episode major depressive disorder patients and subclinical depressive subjects?

2020 ◽  
Author(s):  
Fang Xie ◽  
Xiuhang Ruan ◽  
Guoqing Zhang ◽  
Yuting Li ◽  
E Li ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Visual Recognition ◽  
Inferior Frontal Gyrus ◽  
Low Frequency ◽  
Fusiform Gyrus ◽  
First Episode ◽  
Major Depressive ◽  
Frequency Fluctuations ◽  
The Right

Abstract Background To explore the differences in the fractional amplitude of low-frequency fluctuations (fALFF) at the whole-brain level between young adults with major depressive disorder (MDD) and those with Subclinical depression (SD). Methods Thirty-nine first-episode MDD patients, 30 SD subjects, and 37 healthy controls (HCs) were recruited. All participants underwent resting-state fMRI (Rs-fMRI) scans on a 3T MR scanner. We used the fALFF to explore spontaneous neuronal activity between groups. Results Significant differences in the fALFF were observed among the three groups. Compared with the HCs, an increased fALFF was found in the left cerebellum in MDD patients. When MDD patients were compared with SD subjects, we observed increased fALFF values in the bilateral fusiform gyrus and decreased fALFF values in the right inferior frontal gyrus, right superior frontal gyrus, right middle frontal gyrus, left cuneus and right precuneus. Compared with the HCs, the SD group demonstrated increased fALFF values in the precuneus. Additionally, a positive correlated was revealed between the fALFF values and Hamilton Anxiety Scale (HAMA)score in the right fusiform gyrus in MDD patients. Moreover, the fALFF value were negatively correlated with the Beck Depression Inventory (BDI) score in the right inferior frontal gyrus and with the age in the left fusiform gyrus in SD subjects. Conclusions Our findings suggest that alterations of cognitive and executive networks, default mode networks and visual recognition circuits may contribute to the different neural mechanisms between MDD and SD in young adult subjects.

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