Hyperexcitability of hippocampal CA1 pyramidal neurons in male offspring of a rat model of autism spectrum disorder (ASD) induced by prenatal exposure to valproic acid: A possible involvement of Ih channel current

2019 ◽  
Vol 1708 ◽  
pp. 188-199 ◽  
Author(s):  
Razieh Hajisoltani ◽  
Seyed Asaad Karimi ◽  
Mona Rahdar ◽  
Shima Davoudi ◽  
Mehdi Borjkhani ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Prenatal Exposure ◽  
Rat Model ◽  
Pyramidal Neurons ◽  
Autism Spectrum ◽  
Channel Current ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1 ◽  
Ih Channel

Neurobiological substrates underlying corpus callosum hypoconnectivity and brain metabolic patterns in the valproic acid rat model of autism spectrum disorder

2021 ◽  
Author(s):  
Nonthué Alejandra Uccelli ◽  
Martín Gabriel Codagnone ◽  
Marianela Evelyn Traetta ◽  
Nadia Levanovich ◽  
María Victoria Rosato Siri ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Corpus Callosum ◽  
Rat Model ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Neurobiological Substrates

Cariprazine Alleviates Core Behavioral Deficits in the Prenatal Valproic Acid Exposure Rat Model of Autism Spectrum Disorder

2020 ◽  
Vol 87 (9) ◽  
pp. S148-S149
Author(s):  
Nika Adham ◽  
Andrew Foley ◽  
Lynsey Hanratty ◽  
Béla Kiss ◽  
Bence Farkas ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Rat Model ◽  
Autism Spectrum ◽  
Acid Exposure ◽  
Spectrum Disorder ◽  
Behavioral Deficits

scholarly journals Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

2021 ◽  
Author(s):  
Antonis Asiminas ◽  
Sam A Booker ◽  
Owen R Dando ◽  
Zrinko Kozic ◽  
Daisy Arkell ◽  
...  
Keyword(s):  
Fragile X Syndrome ◽  
Rat Model ◽  
Pyramidal Neurons ◽  
Fragile X ◽  
Autism Spectrum ◽  
Oscillatory Activity ◽  
Ca1 Neurons ◽  
Ca1 Pyramidal Neurons ◽  
Spatial Tuning ◽  
Cognitive Inflexibility

Fragile X syndrome (FXS) is a common single gene cause of intellectual disability and Autism Spectrum Disorder. Cognitive inflexibility is one of the hallmarks of FXS, with affected individuals showing extreme difficulty adapting to novel or complex situations. To explore the neural correlates of this cognitive inflexibility, we used a rat model of FXS (Fmr1 KO), and recorded from the CA1 region of the hippocampus while animals habituated in a novel environment for two consecutive days. On the first day of exploration, the firing rate and spatial tuning of CA1 pyramidal neurons was similar between wild-type (WT) and Fmr1 KO rats. However, while CA1 pyramidal neurons from WT rats showed experience-dependent changes in firing and spatial tuning between the first and second day of exposure to the environment, these changes were decreased or absent in CA1 neurons of Fmr1 KO rats. These findings were consistent with increased excitability of Fmr1 KO CA1 neurons in ex-vivo hippocampal slices, which correlated with reduced synaptic inputs from the medial entorhinal cortex. Lastly, activity patterns of CA1 pyramidal neurons were discoordinated with respect to hippocampal oscillatory activity in Fmr1 KO rats. These findings suggest a network-level origin of cognitive deficits in FXS.

Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid

2021 ◽  
Author(s):  
Yuanyuan Di ◽  
Zhongqi Li ◽  
Jin Li ◽  
Qiangqiang Cheng ◽  
Qi Zheng ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Folic Acid ◽  
Rat Model ◽  
Folic Acid Supplementation ◽  
Autism Spectrum ◽  
Vitamin Supplementation ◽  
Maternal Vitamin ◽  
High Prevalence ◽  
Autistic Behaviors

Maternal vitamin supplementation has been demonstrated to reduce risks of a number of neurodevelopmental diseases in children. Autism spectrum disorder (ASD) is a group of neurodevelopment defects with high prevalence...

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