Neurobiological substrates underlying corpus callosum hypoconnectivity and brain metabolic patterns in the valproic acid rat model of autism spectrum disorder

2021 ◽  
Author(s):  
Nonthué Alejandra Uccelli ◽  
Martín Gabriel Codagnone ◽  
Marianela Evelyn Traetta ◽  
Nadia Levanovich ◽  
María Victoria Rosato Siri ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Corpus Callosum ◽  
Rat Model ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Neurobiological Substrates

Cariprazine Alleviates Core Behavioral Deficits in the Prenatal Valproic Acid Exposure Rat Model of Autism Spectrum Disorder

2020 ◽  
Vol 87 (9) ◽  
pp. S148-S149
Author(s):  
Nika Adham ◽  
Andrew Foley ◽  
Lynsey Hanratty ◽  
Béla Kiss ◽  
Bence Farkas ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Rat Model ◽  
Autism Spectrum ◽  
Acid Exposure ◽  
Spectrum Disorder ◽  
Behavioral Deficits

scholarly journals Preliminary Results Regarding Sleep in a Zebrafish Model of Autism Spectrum Disorder

2021 ◽  
Vol 11 (5) ◽  
pp. 556
Author(s):  
Madalina Andreea Robea ◽  
Alin Ciobica ◽  
Alexandrina-Stefania Curpan ◽  
Gabriel Plavan ◽  
Stefan Strungaru ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Valproic Acid ◽  
Social Behavior ◽  
Antiepileptic Drug ◽  
Alternative Model ◽  
Neurological Diseases ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Zebrafish Model ◽  
Developmental Defects

Autism spectrum disorder (ASD) is one of the most salient developmental neurological diseases and remarkable similarities have been found between humans and model animals of ASD. A common method of inducing ASD in zebrafish is by administrating valproic acid (VPA), which is an antiepileptic drug that is strongly linked with developmental defects in children. In the present study we replicated and extended the findings of VPA on social behavior in zebrafish by adding several sleep observations. Juvenile zebrafish manifested hyperactivity and an increase in ASD-like social behaviors but, interestingly, only exhibited minimal alterations in sleep. Our study confirmed that VPA can generate specific ASD symptoms, indicating that the zebrafish is an alternative model in this field of research.

The effect of age, sex and clinical features on the volume of Corpus Callosum in pre-schoolers with Autism Spectrum Disorder: a case-control study

2017 ◽  
Vol 47 (6) ◽  
pp. 568-578 ◽  
Author(s):  
Alessia Giuliano ◽  
Irene Saviozzi ◽  
Paolo Brambilla ◽  
Filippo Muratori ◽  
Alessandra Retico ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Corpus Callosum ◽  
Clinical Features ◽  
Case Control Study ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Effect Of Age ◽  
Control Study

scholarly journals Changes in brain metabolic connectivity underlie autistic-like social deficits in a rat model of autism spectrum disorder

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Hojin Cho ◽  
Chul Hoon Kim ◽  
Elizabeth Quattrocki Knight ◽  
Hye Won Oh ◽  
Bumhee Park ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Rat Model ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Social Deficits ◽  
Metabolic Connectivity

scholarly journals Erratum: Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Christine Wu Nordahl ◽  
Ana-Maria Iosif ◽  
Gregory S Young ◽  
Lee Michael Perry ◽  
Robert Dougherty ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Sex Differences ◽  
Corpus Callosum ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Preschool Aged Children
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