Low frequency right-sided and high frequency left-sided repetitive transcranial magnetic stimulation for depression: The evidence of equivalence

Background: The efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression has been assessed in a number of acute treatment trials during the last 10 years. Little is known about the long-term impact of the treatment on the disorder and its effectiveness when applied for repeated relapses of depression over time. Method: Nineteen patients who had previously responded to rTMS in clinical trials received treatment with rTMS for a total of 30 episodes of depressive relapse. Results: Approximately 10 months elapsed between treatment episodes. The majority of patients achieved a significant improvement in each treatment course with significant improvements achieved in patients treated with both low-frequency right-sided rTMS and high-frequency left-sided rTMS. Conclusions: The study suggests that rTMS may have value in the treatment of episodes of depressive relapse with little reduction in efficacy over time.

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The effects of different frequencies of repetitive transcranial magnetic stimulation (rTMS) on intracranial neurotransmitters in patients with swallowing disorders after cerebral infarction

10.21203/rs.2.10769/v1 ◽

2019 ◽

Cited By ~ 1

Author(s):

Yupeng Du ◽

Li Wei ◽

Huangwei Jiang

Keyword(s):

Transcranial Magnetic Stimulation ◽

Cerebral Infarction ◽

Test Scores ◽

High Frequency ◽

Magnetic Stimulation ◽

Repetitive Transcranial Magnetic Stimulation ◽

Low Frequency ◽

Swallowing Disorders ◽

Control Group ◽

Low Frequency Rtms

Abstract Objective To study the improvements and mechanism of repetitive transcranial magnetic stimulation (rTMS) on swallowing disorders after cerebral infarction. Methods A total of 60 patients with swallowing disorders were randomly assigned to receive high/low-frequency rTMS treatment, another 30 patients without rTMS treatment were included in the control group. The Kubota’s water-swallowing test, video fluoroscopic swallowing study (VFSS), and major intracranial neurotransmitters were analyzed before and after treatment. Results No significant difference was observed in the Kubota’s water-swallowing test scores, the VFSS scores, or the levels of intracranial neurotransmitters between the three groups before treatment. The Kubota’s water-swallowing test scores were significantly reduced after high-frequency rTMS treatment than in the control group; the aspiration degree was significantly increased after high-frequency rTMS treatment than in the control group; the levels of glutamate and dopamine were significantly increased after high-frequency rTMS treatment than in the control group; Moreover, the Kubota’s water-swallowing test scores were significantly reduced after high-frequency rTMS treatment than after low-frequency rTMS treatment; the levels of glutamate and dopamine were significantly increased after high-frequency rTMS treatment than after low-frequency rTMS treatment. Conclusions High-frequency rTMS was effective for swallowing disorders, which may be related to increased levels of intracranial glutamate and dopamine.

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Reduction of intractable deafferentation pain due to spinal cord or peripheral lesion by high-frequency repetitive transcranial magnetic stimulation of the primary motor cortex

Journal of Neurosurgery ◽

10.3171/jns-07/09/0555 ◽

2007 ◽

Vol 107 (3) ◽

pp. 555-559 ◽

Cited By ~ 90

Author(s):

Youichi Saitoh ◽

Azuma Hirayama ◽

Haruhiko Kishima ◽

Toshio Shimokawa ◽

Satoru Oshino ◽

...

Keyword(s):

Transcranial Magnetic Stimulation ◽

High Frequency ◽

Magnetic Stimulation ◽

Primary Motor Cortex ◽

Repetitive Transcranial Magnetic Stimulation ◽

Low Frequency ◽

Random Order ◽

Precentral Gyrus ◽

Cerebral Lesion ◽

Deafferentation Pain

Object The authors previously reported that navigation-guided repetitive transcranial magnetic stimulation (rTMS) of the precentral gyrus relieves deafferentation pain. Stimulation parameters were 10 trains of 10-second 5-Hz TMS pulses at 50-second intervals. In the present study, they used various stimulation frequencies and compared efficacies between two types of lesions. Methods Patients were divided into two groups: those with a cerebral lesion and those with a noncerebral lesion. The rTMS was applied to all the patients at frequencies of 1, 5, and 10 Hz and as a sham procedure in random order. The effect of rTMS on pain was rated by patients using a visual analog scale. Results The rTMS at frequencies of 5 and 10 Hz, compared with sham stimulation, significantly reduced pain, and the pain reduction continued for 180 minutes. A stimulation frequency of 10 Hz may be more effective than 5 Hz, and at 1 Hz was ineffective. The effect of rTMS at frequencies of 5 and 10 Hz was greater in patients with a noncerebral lesion than those with a cerebral lesion. Conclusions High-frequency (5- or 10-Hz) rTMS of the precentral gyrus can reduce intractable deafferentation pain, but low-frequency stimulation (at 1 Hz) cannot. Patients with a noncerebral lesion are more suitable candidates for high-frequency rTMS of the precentral gyrus.

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Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment

Klinische Neurophysiologie ◽

10.1055/s-0029-1216208 ◽

2009 ◽

Vol 40 (01) ◽

Author(s):

E Frank ◽

T Kleinjung ◽

T Steffens ◽

M Landgrebe ◽

V Vielsmeier ◽

...

Keyword(s):

Transcranial Magnetic Stimulation ◽

Magnetic Stimulation ◽

Repetitive Transcranial Magnetic Stimulation ◽

Low Frequency ◽

Tinnitus Treatment

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About the Effectiveness of Low-frequency Repetitive Transcranial Magnetic Stimulation (LF-rTMS) in the Treatment of Moderate to Severe Recurrent Depressive Disorder

10.26226/morressier.5a7070e2ab9a5f002a4c68fb ◽

2018 ◽

Author(s):

Frederic Lasters

Keyword(s):

Transcranial Magnetic Stimulation ◽

Depressive Disorder ◽

Magnetic Stimulation ◽

Repetitive Transcranial Magnetic Stimulation ◽

Low Frequency

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Faculty Opinions recommendation of Effect of high- and low-frequency repetitive transcranial magnetic stimulation on visuospatial neglect in patients with acute stroke: a double-blind, sham-controlled trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717976316.793474418 ◽

2013 ◽

Author(s):

Shyam Prabhakaran ◽

Shawna Cutting

Keyword(s):

Transcranial Magnetic Stimulation ◽

Acute Stroke ◽

Magnetic Stimulation ◽

Repetitive Transcranial Magnetic Stimulation ◽

Controlled Trial ◽

Low Frequency ◽

Double Blind ◽

Visuospatial Neglect

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High-frequency repetitive transcranial magnetic stimulation enhances layer II/III morphological dendritic plasticity in mouse primary motor cortex

Behavioural Brain Research ◽

10.1016/j.bbr.2021.113352 ◽

2021 ◽

pp. 113352

Author(s):

Marco Cambiaghi ◽

Laura Cherchi ◽

Laura Masin ◽

Carmenrita Infortuna ◽

Nicholas Briski ◽

...

Keyword(s):

Transcranial Magnetic Stimulation ◽

Motor Cortex ◽

High Frequency ◽

Magnetic Stimulation ◽

Primary Motor Cortex ◽

Repetitive Transcranial Magnetic Stimulation ◽

Dendritic Plasticity

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Repetitive transcranial magnetic stimulation as a prophylactic treatment in migraine

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-020-00254-4 ◽

2021 ◽

Vol 57 (1) ◽

Author(s):

Azza B. Hammad ◽

Rasha E. Elsharkawy ◽

Ghada S. Abdel Azim

Keyword(s):

Transcranial Magnetic Stimulation ◽

Serum Level ◽

Pain Intensity ◽

Magnetic Stimulation ◽

Prophylactic Treatment ◽

Repetitive Transcranial Magnetic Stimulation ◽

Low Frequency ◽

Control Group ◽

Neurokinin A ◽

Abortive Treatment

Abstract Background Clinical applications of transcranial magnetic stimulation (TMS) have shown promising results in the treatment of headache disorders, with migraine being one of the most encountered. Objective To assess the role of low-frequency repetitive transcranial magnetic stimulation as a preventive treatment of migraine (with and without aura) and correlate the results with the serum level of the inflammatory biomarker (neurokinin A). Methods Forty patients, with age ranging from 15 to 55 years, diagnosed with migraine (30 migraine without aura and 10 with aura) and 20 apparently healthy individuals, who were age and sex matched with the patient group, were included in this study. A low-frequency (1 Hz) rTMS protocol was applied for all patients for five consecutive days interictally. Assessment of pain intensity using visual analogue scale and frequency and duration of attacks as well as number of pills taken by patients as an abortive treatment according to the Basic Diagnostic Headache Diary for 4 weeks before and 4 weeks after TMS sessions was done. In addition, the Migraine Disability Assessment scale (MIDAS) was applied to assess the severity and degree of disability caused by migraine. Measurement of neurokinin A serum level was done by using ELISA for all patients before and after TMS and for control group once. Results There was a significant reduction in pain intensity, frequency and duration of migraine attacks, migraine disability scores, and number of pills taken as abortive treatment for attacks after rTMS (P < 0.001). Also, serum level of neurokinin A in the patients was significantly reduced after rTMS (P < 0.001). Conclusion Low-frequency rTMS is an effective prophylactic treatment for migraine with and without aura.

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