scholarly journals Bidirectional and state-dependent modulation of brain activity by transcranial focused ultrasound in non-human primates

2021 ◽  
Vol 14 (2) ◽  
pp. 261-272
Author(s):  
Pai-Feng Yang ◽  
M. Anthony Phipps ◽  
Sumeeth Jonathan ◽  
Allen T. Newton ◽  
Nellie Byun ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Brain Activity ◽  
State Dependent ◽  
Transcranial Focused Ultrasound

scholarly journals Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals

2021 ◽  
Vol 15 ◽  
Author(s):  
Tingting Zhang ◽  
Na Pan ◽  
Yuping Wang ◽  
Chunyan Liu ◽  
Shimin Hu
Keyword(s):  
Focused Ultrasound ◽  
Brain Activity ◽  
Pressure Effects ◽  
Spinal Reflexes ◽  
Brain Diseases ◽  
Inhibitory Effects ◽  
Mechanical Pressure ◽  
Non Invasive ◽  
Non Destructive ◽  
Transcranial Focused Ultrasound

Non-invasive neuromodulation technology is important for the treatment of brain diseases. The effects of focused ultrasound on neuronal activity have been investigated since the 1920s. Low intensity transcranial focused ultrasound (tFUS) can exert non-destructive mechanical pressure effects on cellular membranes and ion channels and has been shown to modulate the activity of peripheral nerves, spinal reflexes, the cortex, and even deep brain nuclei, such as the thalamus. It has obvious advantages in terms of security and spatial selectivity. This technology is considered to have broad application prospects in the treatment of neurodegenerative disorders and neuropsychiatric disorders. This review synthesizes animal and human research outcomes and offers an integrated description of the excitatory and inhibitory effects of tFUS in varying experimental and disease conditions.

scholarly journals Differential effects of amplitude-modulated transcranial focused ultrasound on excitatory and inhibitory neurons

2020 ◽  
Author(s):  
Duc T. Nguyen ◽  
Destiny Berisha ◽  
Elisa Konofagou ◽  
Jacek P. Dmochowski
Keyword(s):  
Firing Rate ◽  
Focused Ultrasound ◽  
Multiple Scales ◽  
Brain Activity ◽  
Field Potential ◽  
Pyramidal Cells ◽  
Inhibitory Neurons ◽  
Specific Cell ◽  
Inhibitory Interneurons ◽  
Transcranial Focused Ultrasound

AbstractAlthough stimulation with ultrasound has been shown to modulate brain activity at multiple scales, it remains unclear whether transcranial focused ultrasound stimulation (tFUS) exerts its influence on specific cell types. Here we propose a novel form of tFUS where a continuous waveform is amplitude modulated (AM) at a slow rate (i.e., 40 Hz) targeting the temporal range of electrophysiological activity: AM-tFUS. We stimulated the rat hippocampus while recording multi-unit activity (MUA) followed by classification of spike waveforms into putative excitatory pyramidal cells and inhibitory interneurons. At low acoustic intensity, AM-tFUS selectively reduced firing rates of inhibitory interneurons. On the other hand, higher intensity AM-tFUS increased firing of putative excitatory neurons with no effect on inhibitory firing. Interestingly, firing rate was unchanged during AM-tFUS at intermediate intensity. Consistent with the observed changes in firing rate, power in the theta band (3-10 Hz) of the local field potential (LFP) decreased at low-intensity, was unchanged at intermediate intensity, and increased at higher intensity. Temperature increases at the AM-tFUS target were limited to 0.2°C. Our findings indicate that inhibitory interneurons exhibit greater sensitivity to ultrasound, and that cell-type specific neuromodulation may be achieved by calibrating the intensity of AM-tFUS.

Transcranial Focused Ultrasound to the Thalamus Is Associated with Reduced Extracellular GABA Levels in Rats

2012 ◽  
Vol 65 (3) ◽  
pp. 153-160 ◽  
Author(s):  
Po Song Yang ◽  
Hyungmin Kim ◽  
Wonhye Lee ◽  
Mark Bohlke ◽  
Shinsuk Park ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Transcranial Focused Ultrasound

scholarly journals Transcranial focused ultrasound modulates cortical and thalamic motor activity in awake sheep

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hyun-Chul Kim ◽  
Wonhye Lee ◽  
Jennifer Kunes ◽  
Kyungho Yoon ◽  
Ji Eun Lee ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Brain Activity ◽  
Response Rates ◽  
Behavioral Observation ◽  
Acoustic Stimulation ◽  
Motion Artifacts ◽  
Experimental Conditions ◽  
Low Intensity ◽  
Hind Limbs ◽  
Brain Tissue Damage

AbstractTranscranial application of pulsed low-intensity focused ultrasound (FUS) modulates the excitability of region-specific brain areas, and anesthetic confounders on brain activity warrant the evaluation of the technique in awake animals. We examined the neuromodulatory effects of FUS in unanesthetized sheep by developing a custom-fit headgear capable of reproducibly placing an acoustic focus on the unilateral motor cortex (M1) and corresponding thalamic area. The efferent responses to sonication, based on the acoustic parameters previously identified in anesthetized sheep, were measured using electromyography (EMG) from both hind limbs across three experimental conditions: on-target sonication, off-target sonication, and without sonication. Excitatory sonication yielded greater amplitude of EMG signals obtained from the hind limb contralateral to sonication than that from the ipsilateral limb. Spurious appearance of motion-related EMG signals limited the amount of analyzed data (~ 10% selection of acquired data) during excitatory sonication, and the averaged EMG response rates elicited by the M1 and thalamic stimulations were 7.5 ± 1.4% and 6.7 ± 1.5%, respectively. Suppressive sonication, while sheep walked on the treadmill, temporarily reduced the EMG amplitude from the limb contralateral to sonication. No significant change was found in the EMG amplitudes during the off-target sonication. Behavioral observation throughout the study and histological analysis showed no sign of brain tissue damage caused by the acoustic stimulation. Marginal response rates observed during excitatory sonication call for technical refinement to reduce motion artifacts during EMG acquisitions as well as acoustic aberration correction schemes to improve spatial accuracy of sonication. Yet, our results indicate that low-intensity FUS modulated the excitability of regional brain tissues reversibly and safely in awake sheep, supporting its potential in theragnostic applications.

scholarly journals Safety Review and Perspectives of Transcranial Focused Ultrasound Brain Stimulation

2021 ◽  
Vol 14 ◽  
Author(s):  
Wonhye Lee ◽  
Daniel S. Weisholtz ◽  
Gary E. Strangman ◽  
Seung-Schik Yoo
Keyword(s):  
Brain Stimulation ◽  
Focused Ultrasound ◽  
Safety Review ◽  
Transcranial Focused Ultrasound
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