scholarly journals Modelling large-scale brain network dynamics underlying the TMS-EEG evoked response

2021 ◽  
Vol 14 (6) ◽  
pp. 1714
Author(s):  
Davide Momi ◽  
John Griffiths ◽  
Zheng Wang
Keyword(s):  
Large Scale ◽  
Network Dynamics ◽  
Brain Network ◽  
Evoked Response

scholarly journals Network dynamics with BrainX3: a large-scale simulation of the human brain network with real-time interaction

2015 ◽  
Vol 9 ◽  
Author(s):  
Xerxes D. Arsiwalla ◽  
Riccardo Zucca ◽  
Alberto Betella ◽  
Enrique Martinez ◽  
David Dalmazzo ◽  
...  
Keyword(s):  
Human Brain ◽  
Real Time ◽  
Large Scale ◽  
Network Dynamics ◽  
Brain Network ◽  
Large Scale Simulation ◽  
Time Interaction

scholarly journals A Neuroeconomic Framework for Creative Cognition

2017 ◽  
Author(s):  
Hause Lin ◽  
Oshin Vartanian
Keyword(s):  
Decision Making ◽  
Locus Coeruleus ◽  
Large Scale ◽  
Network Dynamics ◽  
Brain Network ◽  
Creative Cognition ◽  
Decision Making Processes

Neuroeconomics is the study of the neurobiological bases of subjective preferences and choices. We present a novel framework that synthesizes findings from the literatures on neuroeconomics and creativity to provide a neurobiological description of creative cognition. It proposes that value-based decision-making processes and activity in the locus coeruleus-norepinephrine (LC-NE) neuromodulatory system underlie creative cognition, as well as the large-scale brain network dynamics shown to be associated with creativity. This framework allows us to re-conceptualize creative cognition as driven by value-based decision making, in the process providing several falsifiable hypotheses that can further our understanding of creativity, decision making, and brain network dynamics.

scholarly journals Amplification and Suppression of Distinct Brain-wide Activity Patterns by Catecholamines

2018 ◽  
Author(s):  
RL van den Brink ◽  
S Nieuwenhuis ◽  
TH Donner
Keyword(s):  
Spatial Distribution ◽  
Human Brain ◽  
Spatial Patterns ◽  
Large Scale ◽  
Network Dynamics ◽  
Brain Network ◽  
Heterogeneous Distribution ◽  
Neurotransmitter Systems ◽  
The Brain ◽  
Catecholamine Levels

ABSTRACTThe widely projecting catecholaminergic (norepinephrine and dopamine) neurotransmitter systems profoundly shape the state of neuronal networks in the forebrain. Current models posit that the effects of catecholaminergic modulation on network dynamics are homogenous across the brain. However, the brain is equipped with a variety of catecholamine receptors with distinct functional effects and heterogeneous density across brain regions. Consequently, catecholaminergic effects on brain-wide network dynamics might be more spatially specific than assumed. We tested this idea through the analysis of functional magnetic resonance imaging (fMRI) measurements performed in humans (19 females, 5 males) at ‘rest’ under pharmacological (atomoxetine-induced) elevation of catecholamine levels. We used a linear decomposition technique to identify spatial patterns of correlated fMRI signal fluctuations that were either increased or decreased by atomoxetine. This yielded two distinct spatial patterns, each expressing reliable and specific drug effects. The spatial structure of both fluctuation patterns resembled the spatial distribution of the expression of catecholamine receptor genes: α1 norepinephrine receptors (for the fluctuation pattern: placebo > atomoxetine), ‘D2-like’ dopamine receptors (pattern: atomoxetine > placebo), and β norepinephrine receptors (for both patterns, with correlations of opposite sign). We conclude that catecholaminergic effects on the forebrain are spatially more structured than traditionally assumed and at least in part explained by the heterogeneous distribution of various catecholamine receptors. Our findings link catecholaminergic effects on large-scale brain networks to low-level characteristics of the underlying neurotransmitter systems. They also provide key constraints for the development of realistic models of neuromodulatory effects on large-scale brain network dynamics.SIGNIFICANCE STATEMENTThe catecholamines norepinephrine and dopamine are an important class of modulatory neurotransmitters. Because of the widespread and diffuse release of these neuromodulators, it has commonly been assumed that their effects on neural interactions are homogenous across the brain. Here, we present results from the human brain that challenge this view. We pharmacologically increased catecholamine levels and imaged the effects on the spontaneous covariations between brain-wide fMRI signals at ‘rest’. We identified two distinct spatial patterns of covariations: one that was amplified and another that was suppressed by catecholamines. Each pattern was associated with the heterogeneous spatial distribution of the expression of distinct catecholamine receptor genes. Our results provide novel insights into the catecholaminergic modulation of large-scale human brain dynamics.

scholarly journals Large-Scale Brain Network Dynamics Provide a Measure of Psychosis and Anxiety in 22q11.2 Deletion Syndrome

2019 ◽  
Vol 4 (10) ◽  
pp. 881-892 ◽  
Author(s):  
Daniela Zöller ◽  
Corrado Sandini ◽  
Fikret Işik Karahanoğlu ◽  
Maria Carmela Padula ◽  
Marie Schaer ◽  
...  
Keyword(s):  
Large Scale ◽  
Network Dynamics ◽  
22Q11.2 Deletion Syndrome ◽  
Brain Network ◽  
Deletion Syndrome ◽  
22Q11.2 Deletion

scholarly journals Stabilization of Brain Network Dynamics during Childhood and Adolescence is Associated with Gene Expressions

2021 ◽  
Author(s):  
Tianyuan Lei ◽  
Xuhong Liao ◽  
Xiaodan Chen ◽  
Tengda Zhao ◽  
Yuehua Xu ◽  
...  
Keyword(s):  
Large Scale ◽  
Expression Profiles ◽  
Brain Networks ◽  
Network Dynamics ◽  
Brain Network ◽  
Global Network ◽  
Association Cortex ◽  
Childhood And Adolescence ◽  
Gene Expressions ◽  
Age Related

AbstractFunctional brain networks require dynamic reconfiguration to support flexible cognitive function. However, the developmental principles shaping brain network dynamics remain poorly understood. Here, we report the longitudinal development of large-scale brain network dynamics during childhood and adolescence, and its connection with gene expression profiles. Using a multilayer network model, we show the temporally varying modular architecture of child brain networks, with higher network switching primarily in the association cortex and lower switching in the primary regions. This topographical profile exhibits progressive maturation, which manifests as reduced modular dynamics, particularly in the transmodal (e.g., default-mode and frontoparietal) and sensorimotor regions. These developmental refinements mediate age-related enhancements of global network segregation and are linked with the expression profiles of genes associated with the enrichment of ion transport and nucleobase-containing compound transport. These results highlight a progressive stabilization of brain dynamics, which expand our understanding of the neural mechanisms that underlie cognitive development.

scholarly journals EEG resting-state large-scale brain network dynamics are related to depressive symptoms

2019 ◽  
Author(s):  
Alena Damborská ◽  
Miralena I. Tomescu ◽  
Eliška Honzírková ◽  
Richard Barteček ◽  
Jana Hořínková ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Resting State ◽  
Large Scale ◽  
Rating Scale ◽  
Depressive Symptomatology ◽  
Network Dynamics ◽  
Brain Network ◽  
Temporal Characteristics ◽  
Microstate Analysis ◽  
Depressive Episodes

AbstractBackgroundThe few previous studies on resting-state EEG microstates in depressive patients suggest altered temporal characteristics of microstates compared to those of healthy subjects. We tested whether resting-state microstate temporal characteristics could capture large-scale brain network dynamic activity relevant to depressive symptomatology.MethodsTo evaluate a possible relationship between the resting-state large-scale brain network dynamics and depressive symptoms, we performed EEG microstate analysis in patients with moderate to severe depression within bipolar affective disorder, depressive episode, and periodic depressive disorder, and in healthy controls.ResultsMicrostate analysis revealed six classes of microstates (A-F) in global clustering across all subjects. There were no between-group differences in the temporal characteristics of microstates. In the patient group, higher symptomatology on the Montgomery-Åsberg Depression Rating Scale, a questionnaire validated as measuring severity of depressive episodes in patients with mood disorders, correlated with higher occurrence of microstate A (Spearman’s rank correlation, r = 0.70, p < 0.01).ConclusionOur results suggest that the observed interindividual differences in resting-state EEG microstate parameters could reflect altered large-scale brain network dynamics relevant to depressive symptomatology during depressive episodes. These findings suggest the utility of the microstate analysis approach in an objective depression assessment.

scholarly journals Altered Electroencephalographic Resting-State Large-Scale Brain Network Dynamics in Euthymic Bipolar Disorder Patients

2019 ◽  
Vol 10 ◽  
Author(s):  
Alena Damborská ◽  
Camille Piguet ◽  
Jean-Michel Aubry ◽  
Alexandre G. Dayer ◽  
Christoph M. Michel ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Resting State ◽  
Large Scale ◽  
Network Dynamics ◽  
Brain Network
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