Epidemiology of gastrointestinal stromal tumours: Single-institution experience and clinical presentation over three decades

2011 ◽  
Vol 35 (6) ◽  
pp. 515-520 ◽  
Author(s):  
Oddvar M. Sandvik ◽  
Kjetil Søreide ◽  
Jan Terje Kvaløy ◽  
Einar Gudlaugsson ◽  
Jon Arne Søreide
Keyword(s):  
Clinical Presentation ◽  
Gastrointestinal Stromal Tumours ◽  
Single Institution

Long-term outcomes of lumbar microdiscectomy in the pediatric population: a large single-institution case series

2019 ◽  
Vol 24 (5) ◽  
pp. 549-557
Author(s):  
Malia McAvoy ◽  
Heather J. McCrea ◽  
Vamsidhar Chavakula ◽  
Hoon Choi ◽  
Wenya Linda Bi ◽  
...  
Keyword(s):  
Conservative Management ◽  
Functional Outcomes ◽  
Pediatric Patients ◽  
Clinical Presentation ◽  
Case Series ◽  
Csf Leak ◽  
Single Institution ◽  
The Mean

OBJECTIVEFew studies describe long-term functional outcomes of pediatric patients who have undergone lumbar microdiscectomy (LMD) because of the rarity of pediatric disc herniation and the short follow-up periods. The authors analyzed risk factors, clinical presentation, complications, and functional outcomes of a single-institution series of LMD patients over a 19-year period.METHODSA retrospective case series was conducted of pediatric LMD patients at a large pediatric academic hospital from 1998 to 2017. The authors examined premorbid risk factors, clinical presentation, physical examination findings, type and duration of conservative management, indications for surgical intervention, complications, and postoperative outcomes.RESULTSOver the 19-year study period, 199 patients underwent LMD at the authors’ institution. The mean age at presentation was 16.0 years (range 12–18 years), and 55.8% were female. Of these patients, 70.9% participated in competitive sports, and among those who did not play sports, 65.0% had a body mass index greater than 25 kg/m2. Prior to surgery, conservative management had failed in 98.0% of the patients. Only 3 patients (1.5%) presented with cauda equina syndrome requiring emergent microdiscectomy. Complications included 4 cases of postoperative CSF leak (2.0%), 1 case of a noted intraoperative CSF leak, and 3 cases of wound infection (1.5%). At the first postoperative follow-up appointment, minimal or no pain was reported by 93.3% of patients. The mean time to return to sports was 9.8 weeks. During a mean follow-up duration of 8.2 years, 72.9% of patients did not present again after routine postoperative appointments. The total risk of reoperation was a rate of 7.5% (3.5% of patients underwent reoperation for the same level; 4.5% underwent adjacent-level decompression, and one patient [0.5%] ultimately underwent a fusion).CONCLUSIONSMicrodiscectomy is a safe and effective treatment for long-term relief of pain and return to daily activities among pediatric patients with symptomatic lumbar disc disease in whom conservative management has failed.

scholarly journals Clinical presentation of leptospirosis: a retrospective study of 34 patients admitted to a single institution in metropolitan France

2005 ◽  
Vol 11 (5) ◽  
pp. 391-394 ◽  
Author(s):  
S. Jauréguiberry ◽  
M. Roussel ◽  
G. Brinchault-Rabin ◽  
A. Gacouin ◽  
A. Le Meur ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Clinical Presentation ◽  
Single Institution

scholarly journals Septic Arthritis in Paediatric Patients: A 10-year Experience at a Single Institution

2021 ◽  
pp. 201010582110352
Author(s):  
Stacy Wei Ling Ng ◽  
Nicole Teo ◽  
Nicole Kim Luan Lee ◽  
Kevin Boon Leong Lim
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Septic Arthritis ◽  
Clinical Presentation ◽  
Limited Range ◽  
Single Institution ◽  
Tertiary Institution ◽  
Microbiological Profile ◽  
Paediatric Patients ◽  
Limited Range Of Motion

Background We evaluated the clinical presentation and microbiological profile of a cohort of paediatric patients with septic arthritis at a tertiary institution in Singapore. Methods After obtaining institutional board approval, records of all patients below 18 years presenting with septic arthritis between 2010 and 2019 were reviewed. Patient demographic and medical data were analysed. Results Of 24 patients with 26 infected joints with a mean age of 7.1 years, 50.0% had pre-existing atopic dermatitis. The most common site infected was the hip ( n = 11, 42.3%). The most common pathogen isolated from tissue cultures was methicillin-sensitive-Staphylococcus aureus (MSSA) ( n = 9, 37.5%). Twenty-three (95.8%) of the patients underwent surgical drainage. Conclusions The skin of patients with atopic dermatitis has been shown to be more frequently colonised with Staphylococcus aureus compared to healthy individuals. The prevalence of atopic dermatitis in our cohort was higher compared to the reported national average of 20.8%. MSSA was the most commonly reported pathogen, and the hip joint most commonly affected. Less than half of the cohort had positive tissue or blood cultures. In paediatric patients with known atopic dermatitis who present with a fever, a painful joint and limited range of motion, septic arthritis should be considered and early drainage and antibiotics instituted.

Adult Langerhans’ Cell Histiocitosis (LCH). A Single Institution Experience.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3890-3890
Author(s):  
Luis Fayad ◽  
Jimena Cannata
Keyword(s):  
Overall Survival ◽  
Clinical Presentation ◽  
Smoking Habit ◽  
Langerhans Cell ◽  
Risk Category ◽  
Single System ◽  
Single Institution ◽  
Limited Disease ◽  
Agressive Behaviour ◽  
Disseminated Disease

Abstract Langerhans’ cell histiocytosis (LCH) is a rare clonal disorder that affects mainly children. Clinical presentation as well as behaviour are heterogeneous and can range from solitary, relatively benign lesions to a fatal disseminated disease. Although the features have been well described in children, they remain poorly defined in adults. We report the clinical characteristics and outcome of 30 adults from a single institution. Clinical presentation: From 1957 to 2003, 30 patients were diagnosed with LCH at MDA. Median age at presentation was 37 years-old, with 60% of being male. Depending on the organs involved and according to the pediatric classification, 17 cases (57%) had a limited form of LCH (single-system) and 13 cases (43%) had disseminated disease (multisystemic). Patients with single-system LCH had mainly bone (76%) and skin (24%) involvement, which was localized to a single site in 10 cases (58%) and multifocal in the remaining. Patients with limited disease were younger (median age 30 yo). Patients with multisystemic LCH were subdivided into a “high risk” category (5 patients) if lung, liver, spleen, or bone marrow was involved, or into a “low risk” category (8 cases), if none of the risk organs was affected. Six patients had pulmonary involvement, typically as bilateral small nodules although diffuse progressive infiltrates were also present in 2 cases. Clinical course: Patients with limited disease were mainly treated with steroids, radiation, or immunomodulatory agents while those with multifocal or multi-systemic disease had a more agressive behaviour and were treated with systemic therapy. Patients with pulmonary nodules usually responded to systemic steroids and stop of smoking habit. Median of 3 treatments were given (range 1 to 7). Sixty-one percent of patients had a 30-year overall survival (OS). Single-system LCH had a more indolent course (79% OS at 30 years) than multi-systemic LCH (median OS of 16 years). Risk organ involvement was the most important adverse prognostic factor (median OS of 2.2 years vs. 65% OS at 30 years, p: 0.007). Figure 1. Global overall survival on LCH patients Figure 1. Global overall survival on LCH patients Figure 2. Overall survival according to the extent of the disease Figure 2. Overall survival according to the extent of the disease

Thymic neoplasms: clinical presentation, diagnosis and management - A single institution experience

2017 ◽  
Author(s):  
Davorka Mursic ◽  
Sonja Badovinac ◽  
Marta Korsic ◽  
Filip Popovic ◽  
Mihovil Roglic ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Single Institution ◽  
Diagnosis And Management
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