Amphiphilic hyaluronic acid derivatives toward the design of micelles for the sustained delivery of hydrophobic drugs

Skin is an attractive route for drug delivery. However poor permeation of drugs across the skin due to the presence of extremely ordered architecture of outermost layer of skin, led to several investigation to improve the permeability of drugs. Polysaccharides remain widely studied biomaterial for the sustained delivery of drug molecules across the skin. The advance of hyaluronic acid (HA) chemistry with multiple benefits has improved the attention of research groups for its application in the skin transportation of drug molecules. Beginning from the advantages of transdermal route, the present review details the application of HA in transdermal drug delivery. In the last few decades, substantial investigation in the domain has improved the requirement for an outline of all the developments, which is depicted in the review. The review also presented different types of HA based transdermal devices such as transferosomes, nanoemulsions, microneedle etc and their potential to improve the transdermal drug delivery. Furthermore the application of HA through chemical modification as a potential transdermal device is also presented. Keywords: Hyaluronic acid, transdermal drug delivery, microneedles, nanoemulsion, hydrogel

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Self‐assembling cyclodextrin based hydrogels for the sustained delivery of hydrophobic drugs

Journal of Biomedical Materials Research Part A ◽

10.1002/jbm.a.31674 ◽

2008 ◽

Vol 86A (3) ◽

pp. 736-748 ◽

Cited By ~ 42

Author(s):

S. Daoud‐Mahammed ◽

J. L. Grossiord ◽

T. Bergua ◽

C. Amiel ◽

P. Couvreur ◽

...

Keyword(s):

Sustained Delivery ◽

Hydrophobic Drugs ◽

Self Assembling

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Developing hyaluronic acid microgels for sustained delivery of platelet lysate for tissue engineering applications

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2019.10.036 ◽

2020 ◽

Vol 144 ◽

pp. 837-846 ◽

Cited By ~ 4

Author(s):

Elaheh Jooybar ◽

Mohammad J. Abdekhodaie ◽

Marcel Karperien ◽

Abbas Mousavi ◽

Mansour Alvi ◽

...

Keyword(s):

Tissue Engineering ◽

Hyaluronic Acid ◽

Platelet Lysate ◽

Sustained Delivery ◽

Engineering Applications

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Enzymatically crosslinked hyaluronic acid microgels as a vehicle for sustained delivery of cationic proteins

European Polymer Journal ◽

10.1016/j.eurpolymj.2019.03.032 ◽

2019 ◽

Vol 115 ◽

pp. 234-243 ◽

Cited By ~ 7

Author(s):

Elaheh Jooybar ◽

Mohammad J. Abdekhodaie ◽

Abbas Mousavi ◽

Bram Zoetebier ◽

Pieter J. Dijkstra

Keyword(s):

Hyaluronic Acid ◽

Sustained Delivery ◽

Cationic Proteins

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Hyaluronic acid-grafted PLGA nanoparticles for the sustained delivery of berberine chloride for an efficient suppression of Ehrlich ascites tumors

Drug Delivery and Translational Research ◽

10.1007/s13346-018-0485-9 ◽

2018 ◽

Vol 8 (3) ◽

pp. 565-579 ◽

Cited By ~ 9

Author(s):

Priyanka Bhatnagar ◽

Manisha Kumari ◽

Richa Pahuja ◽

A. B. Pant ◽

Y. Shukla ◽

...

Keyword(s):

Hyaluronic Acid ◽

Plga Nanoparticles ◽

Sustained Delivery ◽

Berberine Chloride ◽

Efficient Suppression ◽

Ehrlich Ascites ◽

Ascites Tumors

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Hyaluronic acid decorated pH- and temperature-induced injectable bioconjugates for sustained delivery of bioactive factors and highly efficient wound regeneration

New Journal of Chemistry ◽

10.1039/c9nj03687c ◽

2019 ◽

Vol 43 (48) ◽

pp. 18979-18982

Author(s):

Thavasyappan Thambi ◽

V. H. Giang Phan ◽

Seong Han Kim ◽

Thai Minh Duy Le ◽

Doo Sung Lee

Keyword(s):

Hyaluronic Acid ◽

Tissue Regeneration ◽

Sustained Delivery ◽

Cutaneous Wounds ◽

Highly Efficient

Microporous injectable biogels, composed of hyaluronic acid-poly(β-amino urethane) bioconjugates, which can seal cutaneous wounds and deliver bioactive factors for tissue regeneration have been developed.

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