scholarly journals Transdermal patches fabricated from hyaluronic acid for the enhanced skin penetration of therapeutic entities

2019 ◽  
Vol 9 (1) ◽  
pp. 252-256
Author(s):  
Syam S. Nair
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Transdermal Drug Delivery ◽  
Skin Penetration ◽  
Sustained Delivery ◽  
Research Groups ◽  
Outermost Layer ◽  
Drug Molecules ◽  
Different Types ◽  
Transdermal Route

Skin is an attractive route for drug delivery. However poor permeation of drugs across the skin due to the presence of extremely ordered architecture of outermost layer of skin, led to several investigation to improve the permeability of drugs. Polysaccharides remain widely studied biomaterial for the sustained delivery of drug molecules across the skin. The advance of hyaluronic acid (HA) chemistry with multiple benefits has improved the attention of research groups for its application in the skin transportation of drug molecules. Beginning from the advantages of transdermal route, the present review details the application of HA in transdermal drug delivery. In the last few decades, substantial investigation in the domain has improved the requirement for an outline of all the developments, which is depicted in the review. The review also presented different types of HA based transdermal devices such as transferosomes, nanoemulsions, microneedle etc and their potential to improve the transdermal drug delivery. Furthermore the application of HA through chemical modification as a potential transdermal device is also presented. Keywords: Hyaluronic acid, transdermal drug delivery, microneedles, nanoemulsion, hydrogel

Transdermal Drug delivery: A step towards treatment of cancer

2021 ◽  
Vol 16 ◽  
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Penetration ◽  
Delivery Systems ◽  
New Developments ◽  
Transdermal Drug Delivery Systems ◽  
Transdermal Route

Background: Transdermal drug delivery is an emerging and tempting system over oral and hypodermic drug delivery system. With the new developments in skin penetration techniques, anticancer drugs ranging from hydrophilic macromolecules to lipophilic drugs can be administered via transdermal route to treat cancer. Objective: In the present review, various approaches to enhance the transdermal delivery of drugs is discussed including the micro and nanotechnology based transdermal formulations like chemotherapy, gene therapy, immunotherapy, phototherapy, vaccines and medical devices. Limitations and advantages of various transdermal technologies is also elaborated. Method: In this review, patent applications and recent literature of transdermal drug delivery systems employed to cure mainly cancer are covered. Results: Transdermal drug delivery systems have proved their potential to cure cancer. They increase the bioavailability of drug by site specific drug delivery and can reduce the side effects/toxicity associated with anticancer drugs. Conclusion: The potential of transdermal drug delivery systems to carry the drug may unclutter novel ways for therapeutic intercessions in various tumors.

scholarly journals Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Yi-Qun Yu ◽  
Xue Yang ◽  
Xiao-Fang Wu ◽  
Yi-Bin Fan
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Hydrophilic Drugs ◽  
Non Invasive ◽  
Drug Molecules ◽  
Systemic Side Effects ◽  
Route Of Delivery ◽  
Transdermal Route

The transdermal route of administration provides numerous advantages over conventional routes i.e., oral or injectable for the treatment of different diseases and cosmetics applications. The skin also works as a reservoir, thus deliver the penetrated drug for more extended periods in a sustained manner. It reduces toxicity and local irritation due to multiple sites for absorption and owes the option of avoiding systemic side effects. However, the transdermal route of delivery for many drugs is limited since very few drugs can be delivered at a viable rate using this route. The stratum corneum of skin works as an effective barrier, limiting most drugs’ penetration posing difficulty to cross through the skin. Fortunately, some non-invasive methods can significantly enhance the penetration of drugs through this barrier. The use of nanocarriers for increasing the range of available drugs for the transdermal delivery has emerged as a valuable and exciting alternative. Both the lipophilic and hydrophilic drugs can be delivered via a range of nanocarriers through the stratum corneum with the possibility of having local or systemic effects to treat various diseases. In this review, the skin structure and major obstacle for transdermal drug delivery, different nanocarriers used for transdermal delivery, i.e., nanoparticles, ethosomes, dendrimers, liposomes, etc., have been discussed. Some recent examples of the combination of nanocarrier and physical methods, including iontophoresis, ultrasound, laser, and microneedles, have also been discussed for improving the therapeutic efficacy of transdermal drugs. Limitations and future perspectives of nanocarriers for transdermal drug delivery have been summarized at the end of this manuscript.

scholarly journals BI-GELS: A NOVEL MATERIAL FOR TRANSDERMAL DRUG DELIVERY

2021 ◽  
pp. 1-5
Author(s):  
SARIPILLI RAJESWARI ◽  
RAJESWARI PULLABHATLA ◽  
CHUKKA YERNI SATYAVATHI
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Transdermal Drug Delivery ◽  
Drug Release Rate ◽  
Drug Delivery Vehicles ◽  
Novel Material ◽  
Delivery Vehicles ◽  
Semi Solid ◽  
Transdermal Route ◽  
Application Property

Bi-gels semi solid formulation is combination of organogel and hydrogel with better application property such as pharmaceutical and cosmetics. The main objective of this review is specially focuses on application of bi-gels as drug delivery vehicles by transdermal route. It contains two different phases which are polar and nonpolar due to which, it possess some significant features such as ability to deliver the hydrophilic and hydrophobic drugs which also have improved permeability of drugs, better spreading ability, and water wash ability. Hence, bigels have both organogels and hydrogels they can enhanced hydration of stratum corneum and also had an ability to manipulate the drug release rate from the dosage from.

Nanostructured Metal Films Formed onto Porous Silicon Template

2016 ◽  
Vol 39 ◽  
pp. 235-255
Author(s):  
Hanna Bandarenka ◽  
Alexei Dolgiy ◽  
Eugene Chubenko ◽  
Sergei Redko ◽  
Kseniya Girel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Porous Silicon ◽  
Transdermal Drug Delivery ◽  
Research Work ◽  
Metal Films ◽  
Morphological Pattern ◽  
Mechanical And Electrical Properties ◽  
Different Types ◽  
Review Reports ◽  
Nanostructured Metal

The review reports on the results of our research work on nanostructured metal films onto porous silicon. Principal steps of the techniques allowing fabrication of metal films completely inheriting morphological pattern of different types of porous silicon are presented. It is shown, that giving of the nanostructured pattern to metal films by means of porous silicon template opens their new structural, optical, mechanical and electrical properties, which can be successfully applied in nanoelectronics and biomedicine, particularly including devices based on superconductivity effect, SERS analysis with picomolar sensitivity and transdermal drug delivery by electroporation.

scholarly journals Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels

2016 ◽  
Vol 19 (2) ◽  
pp. 252 ◽  
Author(s):  
Hashem Alsaab ◽  
Sindhu Prabha Bonam ◽  
Dherya Bahl ◽  
Pallabita Chowdhury ◽  
Kenneth Alexander ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Clinical Studies ◽  
Transdermal Drug Delivery ◽  
Present Review ◽  
Therapeutic Drugs ◽  
Delivery Platform ◽  
Transdermal Route ◽  
Transdermal Permeability

Organogels have emerged as an alternative carrier for small and macromolecules via transdermal, oral, rectal and ophthalmic routes. Pluronic lecithin organogels (PLO gels) are lecithin-based organogels widely used in compounding pharmacies as a vehicle for enhancing the transdermal permeability of many therapeutic drugs. However, the scientific and systematic evidence in support of how well PLO gels help in transdermal delivery is scanty. Recently, some clinical studies have reported nearly complete lack of bioavailability of certain topically administered drugs from PLO gels. The present review aims at summarizing gels and organogels, with a focus on the use of PLO gels in transdermal drug delivery. A special emphasis is placed on controversies looming over the use of PLO gels as a delivery platform for drugs via transdermal route. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals Microneedle Array Patches: Characterization and in -vitro Evaluation

2021 ◽  
Vol 30 (1) ◽  
pp. 66-75
Author(s):  
Zainab A. Sadeq
Keyword(s):  
Drug Delivery ◽  
Blood Vessel ◽  
Transdermal Drug Delivery ◽  
Skin Barrier ◽  
Skin Penetration ◽  
Solid Polymer ◽  
Microneedle Array ◽  
Microneedle Patch ◽  
Novel Drug

 Patch in transdermal drug delivery(TDDS) used to overcome the hypodermic drawback, but these patch also have absorption limitation for hydrophilic and macromolecule like peptide and DNA. So that micronized projection have the ability for skin penetration developed named as microneedle.  Microneedle drug delivery system is a novel drug delivery to overcome the limitation of TDDS like skin barrier restriction for large molecule. Microneedle patch can penetrate through skin subcutaneous into epidermis, avoiding nerve fiber and blood vessel contact. There are many type of microneedle patch like solid, polymer, hallow, hydrogel forming microneedle and dissolving microneedle with different method of microfabrication

Ultrasound-mediated transdermal drug delivery of fluorescent nanoparticles and hyaluronic acid into porcine skin in vitro

2016 ◽  
Vol 25 (12) ◽  
pp. 124314 ◽  
Author(s):  
Huan-Lei Wang ◽  
Peng-Fei Fan ◽  
Xia-Sheng Guo ◽  
Juan Tu ◽  
Yong Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Transdermal Drug Delivery ◽  
Fluorescent Nanoparticles ◽  
Porcine Skin

scholarly journals Mathematical Modelling, Simulation and Optimisation of Microneedles for Transdermal Drug Delivery: Trends and Progress

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 693
Author(s):  
Prateek Ranjan Yadav ◽  
Tao Han ◽  
Ololade Olatunji ◽  
Sudip K. Pattanayek ◽  
Diganta Bhusan Das
Keyword(s):  
Drug Delivery ◽  
Mathematical Modelling ◽  
Transdermal Drug Delivery ◽  
Review Paper ◽  
Current Status ◽  
Skin Damage ◽  
Drug Molecules ◽  
Regulatory Affairs ◽  
Modelling Simulation

In the last two decades, microneedles (MNs) have received significant interest due to their potential for painless transdermal drug delivery (TDD) and minimal skin damage. MNs have found applications in a range of research and development areas in drug delivery. They have been prepared using a variety of materials and fabrication techniques resulting in MN arrays with different dimensions, shapes, and geometries for delivery of a variety of drug molecules. These parameters play crucial roles in determining the drug release profiles from the MNs. Developing mathematical modelling, simulation, and optimisation techniques is vital to achieving the desired MN performances. These will then be helpful for pharmaceutical and biotechnological industries as well as professionals working in the field of regulatory affairs focusing on MN based TDD systems. This is because modelling has a great potential to reduce the financial and time cost of both the MNs’ studies and manufacturing. For example, a number of robust mathematical models for predicting the performance of the MNs in vivo have emerged recently which incorporate the roles of the structural and mechanical properties of the skin. In addressing these points, this review paper aims to highlight the current status of the MN modelling research, in particular, the modelling, simulation and optimisation of the systems for drug delivery. The theoretical basis for the simulation of MN enhanced diffusion is discussed within this paper. Thus, this review paper provides a better understanding of the modelling of the MN mediated drug delivery process.

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