A comparative study on the efficiency of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan surface modified nanostructured lipid carrier for ophthalmic delivery of curcumin

2016 ◽  
Vol 146 ◽  
pp. 435-444 ◽  
Author(s):  
Jinyu Li ◽  
Dandan Liu ◽  
Guoxin Tan ◽  
Zhinan Zhao ◽  
Xinggang Yang ◽  
...  
Keyword(s):  
Comparative Study ◽  
Carboxymethyl Chitosan ◽  
Nanostructured Lipid Carrier ◽  
Chitosan Oligosaccharides ◽  
Ophthalmic Delivery ◽  
Surface Modified

scholarly journals SURFACE MODIFIED NANOSTRUCTURED LIPID CARRIER FOR IMPROVED OCULAR DELIVERY: IN VITRO AND EX-VIVO STUDY

2021 ◽  
Vol 11 (6) ◽  
pp. 75-80
Author(s):  
Meenakshi Kanwar Chauhan
Keyword(s):  
Particle Size ◽  
Ex Vivo ◽  
Carboxymethyl Chitosan ◽  
Eye Drops ◽  
Nanostructured Lipid Carrier ◽  
Sustained Drug Release ◽  
Dose Requirement ◽  
Corneal Permeability ◽  
Surface Modified ◽  
Ex Vivo Study

Nano structured lipid carrier (NLC) is a new generation Nano particulate system that offers several advantages over polymeric nanoparticles. However, NLC possesses less muco-adhesiveness in the eye due to its anionic nature. Therefore, the present study aimed to modify the surface of NLC with cationic compounds to improve corneal permeability. The objective of the present study was to prepare and optimize Dexamethasone NLC, surface modification of NLC with carboxymethyl chitosan, and comparative evaluation of both with the marketed formulation. A combined melt emulsification and ultrasonication method was used to prepare NLC. The optimized NLC formulations shown particle size (64±2.3 nm), polydispersity in Dexamethasone (0.270±0.008), zeta potential (-12±3.42 mV), and entrapment efficiency (96.66±0.41%). Carboxymethyl chitosan modified dexamethasone loaded NLC showed particle size (260.73±4.66 nm) and dexamethasone (10.8±6.0 mV). It exhibited sustained drug release than NLC and marketed eye drop. In the ex vivo study, surface modified NLC had a permeability coefficient of 228.88 cm h-1, which is 2.60-and 1.61-times greater than eye drop and NLC, respectively. Surface-modified NLC has shown comparatively sustained release with plain NLC and commercial eye drops. The surface-modified form can adhere firmly with mucin and shown improved trans corneal permeability. Therefore, CNLC would be the potential nanocarrier for dexamethasone to minimize dose requirement and overcome systemic adverse events.

A comparative study on mechanical properties of surface modified polypropylene (PP) fabric reinforced concrete composites

2017 ◽  
Vol 157 ◽  
pp. 372-381 ◽  
Author(s):  
Guyu Feng ◽  
Xinyue Wang ◽  
Diantang Zhang ◽  
Haijian Cao ◽  
Kun Qian ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Reinforced Concrete ◽  
Comparative Study ◽  
Surface Modified

Antioxidant activity of N-carboxymethyl chitosan oligosaccharides

2008 ◽  
Vol 18 (21) ◽  
pp. 5774-5776 ◽  
Author(s):  
Tao Sun ◽  
Qian Yao ◽  
Dongxiang Zhou ◽  
Fang Mao
Keyword(s):  
Antioxidant Activity ◽  
Carboxymethyl Chitosan ◽  
Chitosan Oligosaccharides

Enhanced performances of microbial fuel cells using surface-modified carbon cloth anodes: A comparative study

2014 ◽  
Vol 39 (33) ◽  
pp. 19148-19155 ◽  
Author(s):  
Jun Zhang ◽  
Jun Li ◽  
Dingding Ye ◽  
Xun Zhu ◽  
Qiang Liao ◽  
...  
Keyword(s):  
Fuel Cells ◽  
Comparative Study ◽  
Microbial Fuel Cells ◽  
Carbon Cloth ◽  
Surface Modified

Preparation of surface-modified, micrometer-sized carboxymethyl chitosan drug-loaded microspheres

2017 ◽  
Vol 135 (4) ◽  
pp. 45731 ◽  
Author(s):  
Yuanlong Cao ◽  
Yuanyuan Ding ◽  
Liping Zhang ◽  
Gang Shi ◽  
Xinxin Sang ◽  
...  
Keyword(s):  
Carboxymethyl Chitosan ◽  
Surface Modified
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