Antioxidant activity of N-carboxymethyl chitosan oligosaccharides

Active films based on carboxymethyl chitosan incorporated corn peptide were developed, and the effect of the concentration of corn peptide on films was evaluated. Physicochemical properties of the films, including thickness, opacity, moisture content, color, mechanical properties, water vapor permeability, and oil resistance, were measured. Biological activities of the films, including the antioxidant and antibacterial activities, were characterized in terms of 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging activity, reducing power, the total antioxidant activity, and the filter disc inhibition zone method. The results indicated that the incorporation of corn peptide caused interactions between carboxymethyl chitosan and corn peptide in Maillard reaction and gave rise to the films light yellow appearance. Compared with the Control, the degree of glycosylation, browning intensity, thickness, opacity, tensile strength, antioxidant activity, and antibacterial activity of films were increased, but the elongation, vapor permeability, and oil resistance of films were decreased. The films based on corn peptide and carboxymethyl chitosan can potentially be applied to food packaging.

Download Full-text

Transport mechanism of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan decorated coumarin-6 loaded nanostructured lipid carriers across the rabbit ocular

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2017.08.013 ◽

2017 ◽

Vol 120 ◽

pp. 89-97 ◽

Cited By ~ 14

Author(s):

Jinyu Li ◽

Guoxin Tan ◽

Bingchao Cheng ◽

Dandan Liu ◽

Weisan Pan

Keyword(s):

Transport Mechanism ◽

Carboxymethyl Chitosan ◽

Nanostructured Lipid Carriers ◽

Chitosan Oligosaccharides ◽

Coumarin 6

Download Full-text

Synthesis, Characterization, and Evaluation of Genistein-Loaded Zein/Carboxymethyl Chitosan Nanoparticles with Improved Water Dispersibility, Enhanced Antioxidant Activity, and Controlled Release Property

Foods ◽

10.3390/foods9111604 ◽

2020 ◽

Vol 9 (11) ◽

pp. 1604

Author(s):

Yu Xiao ◽

Chi-Tang Ho ◽

Yulian Chen ◽

Yuanliang Wang ◽

Zihao Wei ◽

...

Keyword(s):

Antioxidant Activity ◽

Controlled Release ◽

Water Solubility ◽

Uv Light ◽

Chitosan Nanoparticles ◽

Carboxymethyl Chitosan ◽

Food Ingredient ◽

Beneficial Effects ◽

Release Property ◽

Water Dispersibility

Genistein is one of major isoflavones derived from soybean products and it is believed to have beneficial effects on human health. However, its low water-solubility and poor oral bioavailability severely hamper its use as a functional food ingredient or for pharmaceutical industry. In this study, zein and zein/carboxymethyl chitosan (CMCS) nanoparticles were prepared to encapsulate genistein using a combined liquid–liquid phase separation method. The physicochemical properties of fabricated nanoparticles were characterized by dynamic light scattering (DLS), atomic force microscopy (AFM), and Fourier transform infrared spectroscopy (FTIR). The results demonstrated that genistein encapsulated with zein nanoparticles significantly improved its water dispersibility, antioxidant activity in the aqueous phase, and photostability against UV light. Moreover, genistein encapsulated in zein nanoparticles showed a sustained release property. Furthermore, it was found that encapsulation efficiency of genistein was significantly enhanced after CMCS coating, and this effect was more pronounced after the complex nanoparticles cross-linked with calcium ions when compared with the use of zein as a single encapsulant. In addition, compared to zein nanoparticles without biopolymer coating, CMCS coating significantly enhanced the thermal and storage stability of the formed nanoparticles, and delayed the release of genistein. A schematic diagram of zein and zein/carboxymethyl chitosan (CMCS) nanoparticles formation mechanism for encapsulation of genistein was proposed. According to the results of the current study, it could be concluded that encapsulation of genistein in zein/CMCS nanoparticles is a promising approach to improve its water dispersibility, antioxidant activity, photostability against UV light and provide controlled release for food/pharmaceutical applications.

Download Full-text

The synthesis and antioxidant activity of the Schiff bases of chitosan and carboxymethyl chitosan

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.06.095 ◽

2005 ◽

Vol 15 (20) ◽

pp. 4600-4603 ◽

Cited By ~ 186

Author(s):

Zhanyong Guo ◽

Ronge Xing ◽

Song Liu ◽

Huahua Yu ◽

Pibo Wang ◽

...

Keyword(s):

Antioxidant Activity ◽

Schiff Bases ◽

Carboxymethyl Chitosan

Download Full-text

Synthesis and Antioxidant Activity of Carboxymethyl Chitosan-Selenium

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.734-737.2100 ◽

2013 ◽

Vol 734-737 ◽

pp. 2100-2103

Author(s):

Li Ming Jin ◽

Ning Geng ◽

Chun Shan Quan ◽

Sheng Di Fan

Keyword(s):

Antioxidant Activity ◽

Hydroxyl Radicals ◽

Sodium Selenite ◽

Antioxidant Activities ◽

Carboxymethyl Chitosan ◽

Superoxide Radicals ◽

Organic Selenium ◽

Antioxidant Effects ◽

Better Than ◽

Scavenging Rates

The objective of this study was to synthesize a new organic selenium compound, carboxymethyl chitosan-selenium (CMCTS-Se), and evaluate its antioxidant abilities on hydroxyl radicals and superoxide radicals. Sodium selenite and carboxymethyl chitosan (CMCTS) were used to prepare CMCTS-Se. It was characterized by ultraviolet (UV) and infrared (IR) techniques. The results proved the successful synthesis of CMCTS-Se. The yield was 44.78% and the content of selenium (Se) was 20.50mg/g determined by colorimetry at 420nm using 3.3-diaminobenzidine as color-produced reagent. The antioxidant activities on hydroxyl radicals and super oxide radicals of CMCTS-Se were investigated. The results showed that antioxidant activities were concentration related in the setting concentration range and the antioxidant effects of CMCTS-Se were totally better than that of CMCTS. The scavenging rates on hydroxyl radicals and superoxide radicals of 2.0mg/mL CMCTS-Se were 68.25% and 62.15%, respectively. VC, a well-known antioxidant, as a standard in our assay, showed a little higher antioxidant activity than CMCTS-Se. This research provides a possible application of CMCTS-Se as a low toxic and effective organic Se-enriched healthy product.

Download Full-text