scholarly journals Structural features and immunological perception of the cell surface glycans of Lactobacillus plantarum: a novel rhamnose-rich polysaccharide and teichoic acids

2020 ◽  
Vol 233 ◽  
pp. 115857 ◽  
Author(s):  
Pilar Garcia-Vello ◽  
Garima Sharma ◽  
Immacolata Speciale ◽  
Antonio Molinaro ◽  
Sin-Hyeog Im ◽  
...  
2017 ◽  
Vol 199 (9) ◽  
pp. 1243-1250 ◽  
Author(s):  
Najla Haddaji ◽  
Abdel Kaim Mahdhi ◽  
Manel Ben Ismaiil ◽  
Amina Bakhrouf

Author(s):  
Hector Sanchez ◽  
Daniel Hopkins ◽  
Sally Demirdjian ◽  
Cecilia Gutierrez ◽  
George A. O’Toole ◽  
...  

2017 ◽  
Vol 2 (12) ◽  
pp. 1635-1647 ◽  
Author(s):  
Renata C. Matos ◽  
Martin Schwarzer ◽  
Hugo Gervais ◽  
Pascal Courtin ◽  
Pauline Joncour ◽  
...  

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 1177
Author(s):  
Anita J. Zaitouna ◽  
Amanpreet Kaur ◽  
Malini Raghavan

Major histocompatibility class I (MHC-I) proteins mediate immunosurveillance against pathogens and cancers by presenting antigenic or mutated peptides to antigen receptors of CD8+ T cells and by engaging receptors of natural killer (NK) cells. In humans, MHC-I molecules are highly polymorphic. MHC-I variations permit the display of thousands of distinct peptides at the cell surface. Recent mass spectrometric studies have revealed unique and shared characteristics of the peptidomes of individual MHC-I variants. The cell surface expression of MHC-I–peptide complexes requires the functions of many intracellular assembly factors, including the transporter associated with antigen presentation (TAP), tapasin, calreticulin, ERp57, TAP-binding protein related (TAPBPR), endoplasmic reticulum aminopeptidases (ERAPs), and the proteasomes. Recent studies provide important insights into the structural features of these factors that govern MHC-I assembly as well as the mechanisms underlying peptide exchange. Conformational sensing of MHC-I molecules mediates the quality control of intracellular MHC-I assembly and contributes to immune recognition by CD8 at the cell surface. Recent studies also show that several MHC-I variants can follow unconventional assembly routes to the cell surface, conferring selective immune advantages that can be exploited for immunotherapy.


2017 ◽  
Vol 2 (28) ◽  
pp. 8865-8869 ◽  
Author(s):  
Madhuri Gade ◽  
Preeti Madhukar Chaudhary ◽  
Hirekodathakallu V. Thulasiram ◽  
Raghavendra Kikkeri

2019 ◽  
Vol 9 (2) ◽  
pp. 20180060 ◽  
Author(s):  
Jochen Zimmer

Essentially all living systems produce complex carbohydrates as an energy source, structural component, protective coat or adhesive for cell attachment. Many polysaccharides are displayed on the cell surface or are threaded through proteinaceous tunnels for degradation. Dictated by their chemical composition and mode of polymerization, the physical properties of complex carbohydrates differ substantially, from amphipathic water-insoluble polymers to highly hydrated hydrogel-forming macromolecules. Accordingly, diverse recognition and translocation mechanisms evolved to transport polysaccharides to their final destinations. This review will summarize and compare diverse polysaccharide transport mechanisms implicated in the biosynthesis and degradation of cell surface polymers in pro- and eukaryotes.


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