Importance of Left Ventricular Geometry in the Occurrence of Isolated Diastolic Heart Failure in Patients

2005 ◽  
Vol 11 (9) ◽  
pp. S297
Author(s):  
Misato Otsuka ◽  
Mio Shuto ◽  
Shinji Nakao ◽  
Akiko Goda ◽  
Masao Yuba ◽  
...  
2007 ◽  
Vol 49 (2) ◽  
pp. 227-236 ◽  
Author(s):  
Farsad Afshinnia ◽  
Samuel Spitalewitz ◽  
Shyan-Yih Chou ◽  
David Z. Gunsburg ◽  
Hal L. Chadow

2009 ◽  
Vol 54 (1) ◽  
pp. 101-107 ◽  
Author(s):  
Kazuaki Uchino ◽  
Tomoaki Ishigami ◽  
Kenji Ohshige ◽  
Teruyasu Sugano ◽  
Toshiyuki Ishikawa ◽  
...  

Open Heart ◽  
2020 ◽  
Vol 7 (1) ◽  
pp. e001105
Author(s):  
Christopher J McAloon ◽  
Samantha Hyndman ◽  
Valerie Ansell ◽  
Paul O'Hare ◽  
Harpal Randeva ◽  
...  

AimsBody composition (BC) is known to alter in heart failure. Cardiac resynchronisation therapy (CRT) improves left ventricular geometry but the impact on BC is unknown. Our aim was to evaluate BC in these patients before and after CRT implantation.MethodsProspective proof-of-concept pilot study of heart failure patients undergoing CRT between September 2014 and December 2015. Assessments performed pre-CRT and post-CRT (6 weeks and 6 months) were: BC parameters (using air-displacement plethysmography), New York Heart Failure classification for assessing symptom severity, echocardiography to assess left ventricular geometry, electrocardiography, Minnesota Heart Failure Questionnaire and N-terminal probrain natriuretic peptide (NT-pro-BNP). Repeated measures analysis of variance was performed to assess relative change over time and potential correlations.ResultsTwenty-five patients were recruited; mean-age (±SD) was 73.4±10.0 years, 23 males, 18 CRT defibrillators (remainder CRT pacemakers), 16 had ischaemic aetiology, 6 diabetics, 17 with left bundle-branch morphology on ECG and 10 had atrial fibrillation. Significant inverse correlations were observed in the first 6 weeks following CRT between fat mass and left ventricular end-diastolic volume (r=−0.69, p<0.01) and NT-pro-BNP and fat mass (r=0.41, p=0.05). No significant differences were noted over 6 months. There was an observed trend towards reduced fat mass in the first 6 weeks post-CRT implant driven by non-responders. There was no significant difference between responders and non-responders in BC over 6 months.ConclusionThis is the first study to observe interplay between BC and cardiac geometry/function following CRT; a trend in overall fat mass reduction was noted following CRT and merits further study.


1998 ◽  
Vol 4 (3) ◽  
pp. 112
Author(s):  
Norihiro Tada ◽  
Izumi Kitagawa ◽  
Rika Shinzato ◽  
Shinobu Matsui ◽  
Hiroichi Tsugawa ◽  
...  

2020 ◽  
Vol 12 (3) ◽  
pp. 233-8
Author(s):  
Johan Gunadi ◽  
Starry Homenta Rampengan ◽  
Janry Antonius Pangemanan ◽  
Agnes Lucia Panda ◽  
Nancy Lampus ◽  
...  

BACKGROUND: Heart failure (HF) is a clinical syndrome caused by structural or functional cardiac disorders and is the final stage of every heart disease, marked by decreased functional capacity and patients’ quality of life (QoL). Suppression of tumorigenicity-2 (ST2) is a biomarker depicting heart fibrosis and remodeling that altered left ventricular geometry, which in turn decreases left ventricular contractility, decreases functional capacity, and ultimately affects the QoL of the HF patient.METHODS: An observational study was conducted with a cross-sectional approach involving 60 patients with systolic heart failure. Left ventricular geometry, left ventricular ejection fraction (LVEF), ST2 level, and other biomarkers were examined, continued by QoL assessment.RESULTS: The ST2 level (33.25±23.55 ng/mL) was negatively correlated with LVEF (r=-0.257; p=0.024) and was positively correlated with QoL (r=0.255; p=0.05). The LVEF was negatively correlated with QoL (r=-0.224; p=0.031). However, no significant correlation was found between left ventricular geometry with ST2 level or patients’ QoL.CONCLUSION: Elevated ST2 levels are correlated with decreased LVEF and worse QoL in systolic heart failure subjects. Therefore, ST2 together with LVEF can be used as prognostic tools for patients with HF.KEYWORDS: heart failure, ST2, left ventricular geometry, left ventricular ejection fraction, quality of life


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