Chloro acridone derivatives as cytotoxic agents active on multidrug-resistant cell lines and their duplex DNA complex studies by electrospray ionization mass spectrometry

2008 ◽  
Vol 176 (2-3) ◽  
pp. 212-219 ◽  
Author(s):  
V.V.S. Rajendra Prasad ◽  
J. Venkat Rao ◽  
R.S. Giri ◽  
N.K. Sathish ◽  
S.M. Shanta Kumar ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Cell Lines ◽  
Electrospray Ionization Mass Spectrometry ◽  
Multidrug Resistant ◽  
Resistant Cell ◽  
Cytotoxic Agents ◽  
Ionization Mass ◽  
Acridone Derivatives ◽  
Dna Complex

Metal mediated sterol receptor-DNA complex association and dissociation determined by electrospray ionization mass spectrometry

1998 ◽  
Vol 16 (3) ◽  
pp. 262-266 ◽  
Author(s):  
Timothy D. Veenstra ◽  
Linda M. Benson ◽  
Theodore A. Craig ◽  
Andy J. Tomlinson ◽  
Rajiv Kumar ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Dna Complex

scholarly journals Polyoxygenated Klysimplexane- and Eunicellin-Based Diterpenoids from the Gorgonian Briareum violaceum

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3276
Author(s):  
Atallah F. Ahmed ◽  
Yang Cheng ◽  
Chang-Feng Dai ◽  
Jyh-Horng Sheu
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Cytotoxic Activity ◽  
Electrospray Ionization ◽  
Cell Lines ◽  
Cancer Cell ◽  
Electrospray Ionization Mass Spectrometry ◽  
Biosynthetic Pathway ◽  
Ionization Mass ◽  
Chemical Structures

Three new polyoxygenated diterpenoids with a rare 4-isopropyl-1,5,8a-trimethylperhydrophenanthrane structure of the klysimplexane skeleton, briarols A‒C (1‒3), and one eunicellin-based diterpenoid, briarol D (4), were isolated from Briareum violaceum, a gorgonian inhabiting Taiwanese waters. The chemical structures of these compounds were determined by employing extensive analyses of NMR and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. Metabolites 1‒3 were found to possess the rarely found skeleton of the diterpenoid klysimplexin T. All isolated compounds showed very weak cytotoxic activity against the growth of three cancer cell lines. A plausible biosynthetic pathway for briarols A‒C from the coexisting eunicellin diterpenoid briarol D (4) was postulated.

Direct Analysis of Tubulin Expression in Cancer Cell Lines by Electrospray Ionization Mass Spectrometry†

Biochemistry ◽  
2003 ◽  
Vol 42 (41) ◽  
pp. 12019-12027 ◽  
Author(s):  
Pascal Verdier-Pinard ◽  
Fang Wang ◽  
Berta Burd ◽  
Ruth Hogue Angeletti ◽  
Susan Band Horwitz ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Cell Lines ◽  
Cancer Cell ◽  
Electrospray Ionization Mass Spectrometry ◽  
Direct Analysis ◽  
Cancer Cell Lines ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass
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