4.P4. Selection for high basal metabolic rate compromises immune response in cold-stressed laboratory mice

Data concerning the energy expenditure of nine species in the family Felidae and one species in the family Hyaenidae are presented, all of which were obtained under standard conditions. An examination of basal rates of metabolism in these felids and in two species reported in the literature indicates that basal rate is primarily correlated with body mass; of these species, nine have a high basal metabolic rate by general mammalian standards, the two exceptions being the margay and jaguarundi. The low basal metabolic rate of the margay may be related to its arboreal habit in association with small muscle mass, but the reason for the low rate in the jaguarundi is unknown. The omnivorous striped hyaena and termitivorous aardwolf have typical mammalian basal rates. Felids that weigh less than 7 kg have slightly low minimal thermal conductances relative to mammals generally; larger species have high conductances. Felids have slightly high body temperatures.

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High Basal Metabolic Rate: Exophthalmic Goitre

Proceedings of the Royal Society of Medicine ◽

10.1177/003591573302601231 ◽

1933 ◽

Vol 26 (12) ◽

pp. 1545-1545

Author(s):

J. M. Smellie

Keyword(s):

Metabolic Rate ◽

Basal Metabolic Rate ◽

High Basal Metabolic Rate

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High Basal Metabolic Rate Is a Risk Factor for Mortality: The Baltimore Longitudinal Study of Aging

The Journals of Gerontology Series A ◽

10.1093/gerona/63.7.698 ◽

2008 ◽

Vol 63 (7) ◽

pp. 698-706 ◽

Cited By ~ 83

Author(s):

C. Ruggiero ◽

E. J. Metter ◽

V. Melenovsky ◽

A. Cherubini ◽

S. S. Najjar ◽

...

Keyword(s):

Risk Factor ◽

Longitudinal Study ◽

Metabolic Rate ◽

Basal Metabolic Rate ◽

Baltimore Longitudinal Study ◽

High Basal Metabolic Rate

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EVOLUTION OF BASAL METABOLIC RATE AND ORGAN MASSES IN LABORATORY MICE

Evolution ◽

10.1111/j.1558-5646.1995.tb04450.x ◽

1995 ◽

Vol 49 (6) ◽

pp. 1239-1248 ◽

Cited By ~ 84

Author(s):

Marek Konarzewski ◽

Jared Diamond

Keyword(s):

Metabolic Rate ◽

Basal Metabolic Rate ◽

Laboratory Mice

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Significance of variation in basal metabolic rate in laboratory mice for translational experiments

Journal of Comparative Physiology B ◽

10.1007/s00360-021-01410-9 ◽

2021 ◽

Author(s):

Paweł Brzęk ◽

Andrzej Gębczyński ◽

Piotr Selewestruk ◽

Aneta Książek ◽

Julita Sadowska ◽

...

Keyword(s):

Physical Activity ◽

Metabolic Rate ◽

Basal Metabolic Rate ◽

Activity Level ◽

Laboratory Mice ◽

Ambient Temperatures ◽

Thermoneutral Zone ◽

Significant Difference ◽

The Mean ◽

Spontaneous Physical Activity

AbstractThe basal metabolic rate (BMR) accounts for 60–70% of the daily energy expenditure (DEE) in sedentary humans and at least 50% of the DEE in laboratory mice in the thermoneutral zone. Surprisingly, however, the significance of the variation in the BMR is largely overlooked in translational research using such indices as physical activity level (PAL), i.e., the ratio of DEE/BMR. In particular, it is unclear whether emulation of human PAL in mouse models should be carried out within or below the thermoneutral zone. It is also unclear whether physical activity within the thermoneutral zone is limited by the capacity to dissipate heat generated by exercise and obligatory metabolic processes contributing to BMR. We measured PAL and spontaneous physical activity (SPA) in laboratory mice from two lines, divergently selected towards either high or low level of BMR, and acclimated to 30 °C (i.e., the thermoneutral zone), 23 or 4 °C. The mean PAL did not differ between both lines in the mice acclimated to 30 °C but became significantly higher in the low BMR mouse line at the lower ambient temperatures. Acclimation to 30 °C reduced the mean locomotor activity but did not affect the significant difference observed between the selected lines. We conclude that carrying out experiments within the thermoneutral zone can increase the consistency of translational studies aimed at the emulation of human energetics, without affecting the variation in physical activity correlated with BMR.

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