scholarly journals Significance of variation in basal metabolic rate in laboratory mice for translational experiments

2021 ◽  
Author(s):  
Paweł Brzęk ◽  
Andrzej Gębczyński ◽  
Piotr Selewestruk ◽  
Aneta Książek ◽  
Julita Sadowska ◽  
...  
Keyword(s):  
Physical Activity ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Activity Level ◽  
Laboratory Mice ◽  
Ambient Temperatures ◽  
Thermoneutral Zone ◽  
Significant Difference ◽  
The Mean ◽  
Spontaneous Physical Activity

AbstractThe basal metabolic rate (BMR) accounts for 60–70% of the daily energy expenditure (DEE) in sedentary humans and at least 50% of the DEE in laboratory mice in the thermoneutral zone. Surprisingly, however, the significance of the variation in the BMR is largely overlooked in translational research using such indices as physical activity level (PAL), i.e., the ratio of DEE/BMR. In particular, it is unclear whether emulation of human PAL in mouse models should be carried out within or below the thermoneutral zone. It is also unclear whether physical activity within the thermoneutral zone is limited by the capacity to dissipate heat generated by exercise and obligatory metabolic processes contributing to BMR. We measured PAL and spontaneous physical activity (SPA) in laboratory mice from two lines, divergently selected towards either high or low level of BMR, and acclimated to 30 °C (i.e., the thermoneutral zone), 23 or 4 °C. The mean PAL did not differ between both lines in the mice acclimated to 30 °C but became significantly higher in the low BMR mouse line at the lower ambient temperatures. Acclimation to 30 °C reduced the mean locomotor activity but did not affect the significant difference observed between the selected lines. We conclude that carrying out experiments within the thermoneutral zone can increase the consistency of translational studies aimed at the emulation of human energetics, without affecting the variation in physical activity correlated with BMR.

scholarly journals Longitudinal changes in sports activity from pre-diagnosis to first five years post-diagnosis: a prospective Chinese breast cancer cohort study

2020 ◽  
Author(s):  
Yuanyuan Lei ◽  
Suzanne C. Ho ◽  
Carol Kwok ◽  
Ashley Cheng ◽  
Ka Li Cheung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Research ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Chinese Women ◽  
Activity Level ◽  
Significant Difference ◽  
The Mean ◽  
After Cancer

Abstract Background: To compare change in level of physical activity between pre-and post- diagnosis of breast cancer in Chinese women.Methods: Based on an on-going prospective study consisting of 1462 Chinese women with early-stage breast cancer, a validated modified Chinese Baecke questionnaire was used to measure physical activity at baseline (12 months before cancer diagnosis), 18-, 36- and 60-months after diagnosis (over the previous 12 months before each interview).Results: The mean level of physical activity at post-diagnosis was 9.6 metabolic equivalent of task (MET)-hours/week, which was significantly higher than that at pre-diagnosis with mean level of 5.9 MET-hours/week ( P < 0.001). The mean levels of physical activity at 18-, 36- and 60-months follow-up were 9.9, 9.8 and 9.3 MET-hours/week, respectively. There was no significant difference between any two of the three follow-ups at post-diagnosis. The proportions of participant who met World Cancer Research Fund/ American Institute for Cancer Research (WCRF/AICR) recommendation before and after cancer diagnosis were both low, being 20.7% and 35.1%, respectively. Compared to pre-diagnosis, most of the patients improved or had no change on level of physical activity at post-diagnosis, with the respective proportion being 48.2% and 43.8%.Conclusions: Adherence to current lifestyle recommendation for cancer survivors, Chinese women with breast cancer significantly increased level of physical activity level after cancer diagnosis, and such improvement was sustained to five years post-diagnosis. The proportion of patients who met the exercise recommendation for cancer survivors was still low. Encouraging patients on the importance of durable high level of physical activity in breast cancer survivorship is warranted.

scholarly journals Effect of academic stress on physical activity level and cognitive functions in first year medical students: An observational study

2020 ◽  
Vol 11 (5) ◽  
pp. 8-11
Author(s):  
Jitendra Sorout ◽  
Satyanath Reddy Kodidala ◽  
Harsha Soni ◽  
Priyanka Singh ◽  
Nirmal Sharma
Keyword(s):  
Physical Activity ◽  
Medical Students ◽  
Cognitive Functions ◽  
Physical Activity Level ◽  
Activity Level ◽  
First Year ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean ◽  
First Year Medical Students

Background: Newly admitted medical students experience a different curriculum, which can be a stressor and may be the reason of stress during student life. Stress may affect physiological, psychological and cognitive functions of the students. Aims and Objective: Aim of the study was to assess the effect of academic stress on physical activity level and cognitive functions in first year medical students. Materials and Methods: This observational study was conducted on 30 healthy newly admitted medical students (18 -25 years). The data was collected thrice, baseline, after two months and after four months. Stress was assessed by using DASS and Cohen perceived stress scale (PSS). GPAQ was used to estimate the physical activity level. And cognitive functions were assessed by using subjective method (MMSE questionnaire) and objective method (P300). Results: No significant difference of mean values of age, height, weight, BMI, physical activity level, DASS score, PSS and P300 latency were observed over the time to which recording was taken. The mean score of PAL represents the high physical activity. But the score of DASS and PSS represent severe and moderate stress level respectively. The significant difference was seen in the mean values of MMSE score and P300 amplitude over the time to which recording taken. Conclusion: The present study results we can conclude that students have stress during their academic period. And this stress might be helpful in potentiating the cognitive functions with the optimum physical activity.

scholarly journals Basal metabolic rate and energy expenditure or rural farmers in Magubike village, Kilosa district, Tanzania

2013 ◽  
Vol 13 (59) ◽  
pp. 8128-8138
Author(s):  
HN Ocan ◽  
◽  
JL Kinabo ◽  
PS Mamiro ◽  
CN Nyaruhucha
Keyword(s):  
Energy Expenditure ◽  
Metabolic Rate ◽  
Total Energy ◽  
Basal Metabolic Rate ◽  
Energy Requirement ◽  
High Energy ◽  
Activity Level ◽  
Rural Farmers ◽  
The Mean

Measurement of basal metabolic rate (BMR) provides an important baseline for the determination of an individual’s total energy requirement. The study sought to establish human energy expenditure of rural farmers in Magubike village in Tanzania, through determination of BMR, physical activity level (PAL) and total energy expenditure (TEE). In addition, the study intended to provide an indication of the level of energy requirement for the rural people of Tanzania. The objective of the study was to determine energy expenditure of farmers in comparison to the mean caloric intake per capita and the WHO/FAO recommended energy requirements for developing countries. A cross-sectional study design involving 33 male and 31 female farmers was conducted on randomly selected households. Basal Metabolic rate and household activities were measured by indirect calorimetry, using the Douglas bag technique. Physical activity Level was measured by twenty-four hour activity diary and TEE calculated as a product of BMR and PAL. Men’s BMR was 4.7 MJ/day while that of women was 4.3 MJ/day. Farmers mean PAL was 2.20 ± 0.25 in men and 2.05 ± 0.23 in females and TEE was 10.24 MJ/day in men and 8.57 MJ/day in women. Both BMR and TEE were higher in men than in women. The measured energy expenditure for digging and weeding were 1.57 ± 0.3 kJ/min; 1.36 ± 0.31kJ/min in men and 1.58 ± 0.3 kJ/min; 1.49 ± 0.33 kJ/min in women. It was revealed that total energy expenditure of farmers in Magubike village was high with the values being above the mean daily calorie requirement per capita for Tanzania (8.15 MJ/day) but within the WHO/FAO recommended energy requirements (11.26 MJ/day) for developing countries. High energy expenditure was attributed to high energy levels spent in farm activities which were manual and labour intensive. This is likely to be the situation in many rural areas of Tanzania. More work on measurement of costs of farm activities and farmers work capacity are necessary to provide recommendations on energy needs of rural farmers.

scholarly journals Longitudinal changes in sports activity from pre-diagnosis to first five years post-diagnosis: a prospective Chinese breast cancer cohort study

2020 ◽  
Author(s):  
Yuanyuan Lei ◽  
Suzanne C. Ho ◽  
Carol Kwok ◽  
Ashley Cheng ◽  
Ka Li Cheung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Research ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Chinese Women ◽  
Activity Level ◽  
Significant Difference ◽  
The Mean ◽  
After Cancer

Abstract Background: To compare change in level of physical activity between pre-and post- diagnosis of breast cancer in Chinese women.Methods: Based on an on-going prospective study consisting of a sample of Chinese women with breast cancer, a validated modified Chinese Baecke questionnaire was used to measure physical activity at baseline (12 months before cancer diagnosis), 18-, 36- and 60-months after diagnosis (over the previous 12 months before each interview). Results: In our cohort of 1462 Chinese women with a mean age of 52 years, the mean level of physical activity at post-diagnosis was 9.6 metabolic equivalent of task (MET)-hours/week, which was significantly higher than that at pre-diagnosis with mean level of 5.9 MET-hours/week (P < 0.001). The mean levels of physical activity at 18-, 36- and 60-months follow-up were 9.9, 9.8 and 9.3 MET-hours/week, respectively. There was no significant difference between any two of the three follow-ups at post-diagnosis. The proportions of participant who met World Cancer Research Fund/ American Institute for Cancer Research (WCRF/AICR) recommendation before and after cancer diagnosis were both low, being 20.7% and 35.1%, respectively. Compared to pre-diagnosis, most of the patients improved or had no change on level of physical activity at post-diagnosis, with the respective proportion being 48.2% and 43.8%. Conclusions: Adherence to current lifestyle recommendation for cancer survivors, Chinese women with breast cancer significantly increased level of physical activity level after cancer diagnosis, and such improvement was sustained to five years post-diagnosis. The proportion of patients who met the exercise recommendation for cancer survivors was still low. Encouraging patients on the importance of durable high level of physical activity in breast cancer survivorship is warranted.

scholarly journals Physical Activity Level and Energy Expenditure of Clinical Physiotherapists and Physiotherapy Educators in Selected Tertiary Health and Educational Institutions in South-West Nigeria

2019 ◽  
Vol 13 (2) ◽  
pp. 1-9
Author(s):  
AYODEJI A. Fabunmi
Keyword(s):  
Physical Activity ◽  
Energy Expenditure ◽  
Physical Activity Level ◽  
Negative Relationship ◽  
Activity Level ◽  
Activity Levels ◽  
Pearson Product Moment Correlation ◽  
Significant Difference ◽  
Physical Activity Levels ◽  
The Mean

Background: Physiotherapists are trained in the use of physical activity for health promotion, and therefore are expected to be physically active themselves. Aim of the Study: This study determined the physical activity level and energy expenditure of clinical physiotherapists and physiotherapy educators. Materials and Methods: The research design is cross-sectional survey. Sixty participants were selected using the consecutive sampling technique. A pedometer (Omron) was used to measure the number of steps taken by the participants, the distance covered, and the overall energy expenditure. The number of steps was used to classify the participants’ physical activity levels. The data obtained were analysed using descriptive statistics and frequency, percentages and chi-square inferential statistics, Pearson product-moment correlation, Spearman’s rank correlation, independent t-tests and Mann-Whitney U tests. The alpha level was set at 0.05. Results: The mean age and BMI of all participants were 36.81±7.86 years and 26.16±4.46kg/m2 respectively. The average number of steps taken per day was 8002±3411 and the mean energy expenditure was 248.26±182.92kcal. This study revealed that 21.3% of the participants were sedentary, 27.7% were ‘low active’, 27.7% were moderately active, 10.6% were active and 12.8% were highly active. The Pearson product-moment correlation coefficient showed a significant negative relationship between the number of steps and age (r = -0.292 p= 0.047) and a significant positive relationship between the number of steps and energy expenditure (r = 0.325; p = 0.026), respectively. There was a significant inverse relationship between the number of steps, the energy expenditure and the age of the participants. There was no significant difference in the number of steps per day, PAL and energy expenditure between clinical physiotherapists and physiotherapy educators. Conclusion: Physiotherapists should improve their physical activity levels, as most of them (76.7%) were classified in the low activity level category.

scholarly journals Physical Activity, Nutritional Status, Basal Metabolic Rate, and Total Energy Expenditure of Indonesia Migrant Workers during Covid-19 Pandemic

2020 ◽  
Vol 5 (2) ◽  
Author(s):  
I Putu Agus Dharma Hita ◽  
B. M. Wara Kushartanti ◽  
Fitri Agung Nanda
Keyword(s):  
Physical Activity ◽  
Energy Expenditure ◽  
Nutritional Status ◽  
Metabolic Rate ◽  
Total Energy ◽  
Basal Metabolic Rate ◽  
Migrant Workers ◽  
Physical Activity Level ◽  
Total Energy Expenditure ◽  
Activity Level

Physical activity, nutritional status, and total energy expenditure are important components of a human. The purpose of this study was to find out the depiction of physical activity, nutritional status, basal metabolic rate, and total energy expenditure of Indonesia migrant workers during Covid-19 pandemic. The study was a survey study with a descriptive design. The samples were 86 Indonesia migrant workers. The instrument used was the 24 hour recall physical activity sheet for 14 days. The result of the study showed that: 88% of male samples and 95% of female samples gained physical activity level score in low category. The PAL score of the male samples was 1.56, while the PAL score of female samples was 1.52. Related to body mass index, 51% of Indonesia migrant workers were in the normal category; 27% were in the overweight category; 17% were in the Obese I Category, and 5% were in the Obese II category. 22 Indonesia migrant workers in overweight category had low physical activity category, 15 persons in Obesity I category had low physical activity category, and 4 persons in Obese II category. The average of the BMR of the samples during the quarantine, due to Covid-19 pandemic, was 1669 kkal/day for male and 1335 kkal/day for female. The average of total energy expenditure of the samples during Covid-19 quarantine was 2595 kkal/day for male and 2031 kkal/day for female. The physical activity level was low, the nutrition status was normal, total energy expenditure was low, the BMR of the sample was dominated by age factor, sex, and weight of the sample. The result of the study was expected to be a reference of regional and other quarantine systems to improve the immunity system during the 14 days of quarantine.

scholarly journals Enegy expenditure, physical activity and basal metabolic rate of elderly subjects

1995 ◽  
Vol 73 (4) ◽  
pp. 571-581 ◽  
Author(s):  
Daphne L.E. Pannemans ◽  
Klaas R. Westerterp
Keyword(s):  
Physical Activity ◽  
Young Adults ◽  
Energy Expenditure ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Nutrient Intake ◽  
The Elderly ◽  
Activity Level ◽  
Positive Effect ◽  
Energy And Nutrient Intake

Energy expenditure, and therefore energy requirement, generally decreases with advancing age because of a decrease in basal metabolic rate (BMR) and physical activity. The aim of the present study was to measure total energy expenditure (EE) and activity level in a group of healthy elderly (sixteen men aged 71·3 (SD 4·9) years; ten women aged 67·6 (SD 4·1) years) and young adults (nineteen men aged 30·4 (SD 5·0) years; ten women aged 27·2 (SD 3·9) years) by using the doubly-labelled water method in combination with measurements of BMR. Age-related differences in body composition and their relationship to BMR and activity level were studied. EE was lower in elderly compared with young adults, partly due to a significantly lower BMR. The lower BMR was not fully explained by the lower fat-free mass (FFM) in the elderly. Energy expended (MJ/d) on activity was higher for the younger subjects although there was no significant difference in the physical activity index (PAI = EE/BMR) between the two age groups. The effect of physical activity level is twofold: first it has a positive effect on the BMR, and second it has a positive effect on the FFM. Both effects involve an increase in the total EE with an increased level of physical activity. At energy balance this will lead to increased energy and nutrient intake, making especially the elderly less vulnerable to inadequate energy and nutrient intake.

scholarly journals Effects of Physical Activity on Body Composition and Basal Metabolic Rate of Taiwanese Aboriginal Children during Daily School Time

2009 ◽  
Vol 15 (1) ◽  
pp. 6-11
Author(s):  
T. H. TSAO ◽  
HSU C. H. HSU ◽  
Cheng Iuan HUANG ◽  
Huei Ying Huei Ying WU
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Metabolic Rate ◽  
Basal Metabolic Rate ◽  
Vigorous Physical Activity ◽  
Bioelectrical Impedance ◽  
The Body ◽  
Activity Level ◽  
School Time ◽  
Aboriginal Children

LANGUAGE NOTE | Document text in English; abstract also in Chinese. Physical activity is one of the important factors for maintaining weight in adults and children, especially moderate-to- vigorous physical activity (MVPA). However, few studies have discussed about physical activity and body composition of aboriginal children, in spite of the differences existing between aboriginal and non-aboriginal children. As a result, the aim of this study was to investigate the effects of physical activity on the body composition and basal metabolic rate (BMR) of Taiwanese aboriginal children. Methods: Thirty boys (aged 10.7 ± 1.5 yr with a body-mass index (BMI) of 19.0 ± 4.2 kg/m2) and 26 girls (aged 10.0 ± 1.5 yr with a BMI of 18.2 ± 3.7 kg/m2) participated in this study. Bouchard's physical activity questionnaire was used to measure the physical activity level. The body composition and BMR were determined by a bioelectrical impedance analysis. Results: For all subjects, the period of school time, from leaving home to arriving back home, was totally 530 ± 38minutes. Children engaged in 353.8 ± 29.7 (66%), 121.9 ± 9.7 (23%), 37.1 ± 7.5 (7%), and 21.4 ± 7.0 (4%) minutes of sedentary, light, moderate, and vigorous levels of exercise, respectively. The accumulated time of MVPA was significantly higher for boys than for girls. In addition, after the statistical analysis, MVPA was significantly related to the percent body fat and BMR (-0.79 and 0.63; p < 0.05). Conclusions: Sufficient physical activity time, especially MVPA, benefits the maintenance of a normal BMI range for aboriginal children. 身體活動對維持成人與孩童的體重相當重要，特別是中度與激烈程度的身體活動。儘管原住民與非原住民孩童存在著差異，但原住民兒童身體活動與身體組成的關係卻很少被討論。因此，本研究目的探討身體活動對原住民兒童身體組成與基礎代謝率的影響。30位原住民男學童(年齡：10.7 ± 1.5歲，身體質量指數：19.0 ± 4.2 kg/m2)與26位原住民女學童(年齡： 10.0 ± 1.5歲，身體質量指數：18.2 ± 3.7 kg/m2)參與本研究。Bouchard身體活動問卷調查原住民學童不同程度的身體活動，並以生物電阻法原理測量身體組成與基礎代謝率。結果：在校時間，從離家至返家，總計為530 ± 38分鐘。在坐式、輕度、中度、激烈等不同程度的身體活動時間 > 分別為353.8 ± 29.7 (66%)、121.9 ± 9.7 (23%)、37.1 ± 7.5 (7%)、21.4 ± 7.0 (4%)分鐘。男原住民學童在學校累積的中度-激烈的身體活動時間顯著多於女原住民學童。再者，中度-激烈的身體活動時間與原住民學童的體脂肪百分比、基礎代謝率有顯著相關(079、0.63; p < 0.05)。結論：足夠的身體活動時間，特別是中度-激烈程度的身體活動，將有助於原住民學童維持身體質量指數在正常範圍。

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