Inhibition of Aedes aegypti DNA topoisomerase II by etoposide: Impact on survival and morphology of larvae and pupae

2021 ◽  
pp. 109066
Author(s):  
Daniele Santos ◽  
Helga F. Gomes ◽  
Lupis Ribeiro ◽  
André B. Farias ◽  
Nelilma C. Romeiro ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Impact On Survival

The in vivo distribution and dynamics of DNA topoisomerase II in Drosophila embryonic nuclei and chromosomes

1993 ◽  
Vol 51 ◽  
pp. 74-75
Author(s):  
Jason R. Swedlow ◽  
Neil Osheroff ◽  
Tim Karr ◽  
John W. Sedat ◽  
David A. Agard
Keyword(s):  
Topoisomerase Ii ◽  
Biochemical Characterization ◽  
Developmental Cycle ◽  
Dna Topoisomerase Ii ◽  
Chromosomal Distribution ◽  
Dna Topoisomerase ◽  
Ideal System ◽  
Dnase Treatment

DNA topoisomerase II is an ATP-dependent double-stranded DNA strand-passing enzyme that is necessary for full condensation of chromosomes and for complete segregation of sister chromatids at mitosis in vivo and in vitro. Biochemical characterization of chromosomes or nuclei after extraction with high-salt or detergents and DNAse treatment showed that topoisomerase II was a major component of this remnant, termed the chromosome scaffold. The scaffold has been hypothesized to be the structural backbone of the chromosome, so the localization of topoisomerase II to die scaffold suggested that the enzyme might play a structural role in the chromosome. However, topoisomerase II has not been studied in nuclei or chromosomes in vivo. We have monitored the chromosomal distribution of topoisomerase II in vivo during mitosis in the Drosophila embryo. This embryo forms a multi-nucleated syncytial blastoderm early in its developmental cycle. During this time, the embryonic nuclei synchronously progress through 13 mitotic cycles, so this is an ideal system to follow nuclear and chromosomal dynamics.

DNA Topoisomerase II Enzymes as Molecular Targets for Cancer Chemotherapy

2010 ◽  
Vol 999 (999) ◽  
pp. 1-14 ◽  
Author(s):  
K. Chikamori ◽  
A.G. Grozav ◽  
T. Kozuki ◽  
D. Grabowski ◽  
R. Ganapathi ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Topoisomerase Ii ◽  
Molecular Targets ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase

scholarly journals Multiple forms and cellular localization of Drosophila DNA topoisomerase II.

1986 ◽  
Vol 261 (17) ◽  
pp. 8063-8069
Author(s):  
R A Heller ◽  
E R Shelton ◽  
V Dietrich ◽  
S C Elgin ◽  
D L Brutlag
Keyword(s):  
Cellular Localization ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Multiple Forms ◽  
Dna Topoisomerase

scholarly journals Proteasomal inhibition potentiates drugs targeting DNA topoisomerase II

2016 ◽  
Vol 103 ◽  
pp. 29-39 ◽  
Author(s):  
Ka C. Lee ◽  
Rebecca L. Bramley ◽  
Ian G. Cowell ◽  
Graham H. Jackson ◽  
Caroline A. Austin
Keyword(s):  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Proteasomal Inhibition

ChemInform Abstract: Syntheses of Novel Antitumor Dihydroxanthone Derivatives with Inhibitory Activity Against DNA Topoisomerase II.

ChemInform ◽  
2010 ◽  
Vol 30 (52) ◽  
pp. no-no
Author(s):  
Seiichi Sato ◽  
Yasuyo Suga ◽  
Toshihiko Yoshimura ◽  
Ryusuke Nakagawa ◽  
Takashi Tsuji ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase
Sign in / Sign up

Export Citation Format

Share Document